Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury

American Journal of Physiology. Heart and Circulatory Physiology
Stefano ToldoAntonio Abbate

Abstract

Myocardial ischemia-reperfusion injury induces a sterile inflammatory response, leading to further injury that contributes to the final infarct size. Locally released danger-associated molecular patterns lead to priming and triggering of the NOD-like receptor protein 3 inflammasome and amplification of the inflammatory response and cell death by activation of caspase-1. We review strategies inhibiting priming, triggering, or caspase-1 activity or blockade of the inflammasome-related cytokines interleukin-1β and interleukin-18, focusing on the beneficial effects in experimental models of acute myocardial infarction in animals and the initial results of clinical translational research trials.

References

Aug 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·J GaleaC M Holt
Jun 20, 1998·The Journal of Biological Chemistry·K BurnsJ Tschopp
Jun 10, 1998·Cytokine & Growth Factor Reviews·C A Dinarello
Jun 20, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·G C ParryR R Cobb
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·A J PurenC A Dinarello
Mar 18, 1999·Journal of Clinical Immunology·G Fantuzzi, C A Dinarello
Nov 18, 2000·Heart·Y SetaM Kurabayashi
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·B J PomerantzC A Dinarello
Aug 14, 2001·Journal of the American College of Cardiology·G ValenG K Hansson
Dec 18, 2001·Cardiovascular Research·Nikolaos G FrangogiannisMark L Entman
Nov 29, 2002·Pflügers Archiv : European journal of physiology·Alain CombesCharles F McTiernan
Jun 6, 2003·Journal of Molecular and Cellular Cardiology·Stefan FrantzRalph A Kelly
Jul 4, 2003·The Journal of Biological Chemistry·Qun ChenEdward J Lesnefsky
May 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jae-Kwon LeeCharles A Dinarello
Nov 9, 2004·Current Opinion in Cell Biology·Aimee L Edinger, Craig B Thompson
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ingrid E DumitriuPatrizia Rovere-Querini
Sep 17, 2005·Trends in Cardiovascular Medicine·Nikolaos G Frangogiannis, Mark L Entman
Jan 13, 2006·Nature·Fabio MartinonJürg Tschopp
Mar 8, 2006·Immunology and Cell Biology·Masoud H ManjiliJohn R Subjeck
May 30, 2006·Nature Medicine·Mihai G NeteaJos W M van der Meer
Oct 13, 2006·Journal of Leukocyte Biology·Marco E Bianchi
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Dec 12, 2007·Handbook of Experimental Pharmacology·Alexzander Asea
Feb 29, 2008·Nature·Noboru MizushimaDaniel J Klionsky
May 1, 2008·PloS One·Martina ProellRobert Schwarzenbacher
Aug 16, 2008·Shock·José C Alves-FilhoFernando Q Cunha
Jan 17, 2009·Nature Reviews. Microbiology·Tessa BergsbakenBrad T Cookson
Jan 24, 2009·The Journal of Biological Chemistry·Kaliyamurthi VenkatachalamBysani Chandrasekar
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicole B BryanChristian Stehlik
Mar 24, 2009·Annual Review of Immunology·Charles A Dinarello
Jul 28, 2009·Journal of Molecular and Cellular Cardiology·Marcin DobaczewskiNikolaos G Frangogiannis
Oct 7, 2009·The Journal of Cell Biology·Mohamed LamkanfiVishva M Dixit
Nov 19, 2009·Journal of Cardiovascular Pharmacology·Benjamin W Van TassellAntonio Abbate
Jan 8, 2010·Cardiovascular Research·Olga BarreiroFrancisco Sánchez-Madrid
Mar 24, 2010·Annual Review of Immunology·Kenneth L RockHajime Kono

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Citations

Jul 30, 2019·Journal of Cardiovascular Pharmacology·Masafumi Takahashi
Aug 17, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Paras K MishraTakashi Matsui
Aug 16, 2019·Journal of Cardiovascular Pharmacology·Adolfo Gabriele MauroAntonio Abbate
Apr 24, 2020·Circulation Research·Antonio AbbateCharles A Dinarello
Jul 30, 2019·Journal of Cardiovascular Pharmacology·Coert J Zuurbier
Aug 15, 2020·Journal of Cellular Physiology·Alessandra VecchiéAntonio Abbate
Aug 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Georg Daniel DuerrSe-Chan Kim
Sep 26, 2020·Frontiers in Pharmacology·Qianqian LiYi Wang
Aug 24, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Takeshi SuetomiJoan Heller Brown
May 14, 2019·Frontiers in Cardiovascular Medicine·Nicola PotereStefano Toldo
Jan 23, 2020·Cells·Aldo BonaventuraFabrizio Montecucco
Sep 29, 2020·Frontiers in Psychology·Marek JankowskiJolanta Gutkowska
Jan 31, 2019·International Journal of Molecular Sciences·Nicola PotereAntonio Abbate
Oct 22, 2020·International Journal of Molecular Sciences·Sandra Feijóo-BandínFrancisca Lago
May 1, 2020·Current Cardiology Reviews·Yaniel Castro-Torres, Richard E Katholi
Dec 22, 2020·Plastic and Reconstructive Surgery·Francesca FerraraGiuseppe Valacchi
Feb 17, 2021·Npj Regenerative Medicine·Luiza Farache Trajano, Nicola Smart
Feb 26, 2021·Basic Research in Cardiology·Lucie PearceDerek M Yellon
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eleonora MezzaromaStefano Toldo
Apr 14, 2020·Current Pharmaceutical Design·Konstantinos MourouzisDimitris Tousoulis
Mar 9, 2019·Free Radical Biology & Medicine·Hong YuRonald J Korthuis
Nov 5, 2020·Cellular Signalling·Ryan M BurkeEric M Small
Apr 17, 2021·Current Opinion in Biotechnology·Emilia NeuwirtOlaf Groß
Dec 21, 2018·International Immunopharmacology·Chang JiaMaoping Chu
May 21, 2021·Molecular Biology Reports·Shirin SaberianpourMahdi Ahmadi
May 18, 2021·Frontiers in Pharmacology·Junteng ZhouXin Cao
May 28, 2021·Journal of Molecular and Cellular Cardiology·Yu BianBaofeng Yang
Jun 29, 2021·Frontiers in Immunology·Corbin E GoerlichMuhammad M Mohiuddin

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