journal cover

Inflammasomes in neuroinflammatory and neurodegenerative diseases

EMBO Molecular Medicine

Apr 23, 2019

Sofie VoetGeert van Loo

Get paper from

Abstract

Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-β, α-synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well a...read more

Mentioned in this Paper

Amyloid
Astrocytes
Brain
Cell Death
Histiocytes
Inflammation
Nerve Degeneration
Neurons
Cytokine
Intracellular
6
72
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Astrocytes and Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes & Amyloid

The relationship between astrocytes and amyloid has been suggested in some neurological diseases such as Alzheimer’s disease. Neuronal damage stimulates the activation of reactive astrocytes, which may the source of amyloid that forms in Alzheimer’s. Here is the latest research on astrocytes and amyloid.

Astrocytes & Huntington’s Disease

Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Myeloid Cells And Neuroinflammation

Myeloid cells in the CNS are innate immune cells that are essential for brain development and maintenance. Here is the latest research on myeloid cells, including microglia, in neuroinflammation.

Innate Immunity: Neurodegeneration

The innate immune system is a first line of defense against infection. Pathological states can occur if there is over activation of the innate immune system, particularly in the. The excessive activation of these cells can lead to inflammation and neurodegenerative diseases. Here is the latest research on innate immunity and neurodegeneration.

Microglia And CNS Diseases

Microglia are resident macrophages of the CNS. They play a role in scavenging the CNS for plaques, phagocytosis, and extracellular signaling. Here is the latest research on their role in CNS diseases.

Inflammasome and Pyroptosis

Pyroptosis is a form of necrotic and inflammatory programmed cell death induced by inflammatory caspases, one of which is activated by Inflammasome, a multiprotein oligomer responsible for the activation of inflammatory responses. Discover the latest research on inflammasome and pyroptosis here.

Myeloid Cells & Neuroinflammation

Myeloid cells in the CNS are innate immune cells that are essential for brain development and maintenance. Here is the latest research on myeloid cells, including microglia, in neuroinflammation.

Neuroinflammation

Neuroinflammation is a defensive response, characterized by the activation of proinflammatory molecules including microglia and astrocytes. The response has been implicated in brain injuries, acute and chronic neurological and neurodegenerative disorders such as Alzheimer’s disease. Here is the latest research on neuroinflammation.

Microglia: Health and Disease

Microglia are the resident macrophages of the central nervous system. Microglia-derived inflammatory neurotoxins play a principal role in the pathogenesis of several neurodegenerative disorders. Here is the latest research on the role of microglia in health and disease.

© 2019 Meta ULC. All rights reserved

Inflammasomes in neuroinflammatory and neurodegenerative diseases

EMBO Molecular Medicine

Apr 23, 2019

Sofie VoetGeert van Loo

PMID: 31015277

DOI: 10.15252/emmm.201810248

Abstract

Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-β, α-synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well a...read more

Mentioned in this Paper

Amyloid
Astrocytes
Brain
Cell Death
Histiocytes
6
72

Similar Papers Found In These Feeds

Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Get paper from

/papers/inflammasomes-in-neuroinflammatory-and/31015277