Inflammation: a bridge between postoperative cognitive dysfunction and Alzheimer's disease

Medical Hypotheses
Zhonghua HuXianzhen Jiang

Abstract

Postoperative cognitive dysfunction (POCD) which is a decline in cognitive function after surgery can present days to weeks after surgery and may remain a permanent disorder. The exact pathophysiological mechanism of POCD is still unknown. In view the incidence of POCD does not seem to be influenced by the depth and the type of anesthesia, many investigators believe that inflammatory response plays a key role in the pathogenesis of POCD. Animals and human studies show POCD associates with peripheral inflammatory and neuroinflammatory response. Alzheimer's disease (AD) is a insidious and progressive neurodegenerative disorder of the elderly. In clinical practice AD trials have not provided a satisfactory approach for the prevention and therapy. It is because we still do not know its exact etiological factor and pathogenesis. Similarly, neuroinflammatory response is involved in the pathophysiological process of AD. The activation of microglia may be the common pathogenesis of POCD and AD. We hypothesize that inflammatory response is the initial factor of the occurrence and development of POCD and AD. Neuroinflammatory response associates with POCD and AD. The effective pathway to prevention and therapy of POCD and AD should consi...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J D BuxbaumP Greengard
Feb 1, 1997·British Journal of Anaesthesia·P Sheeran, G M Hall
Mar 14, 1998·Trends in Neurosciences·V W YongD R Edwards
Jan 5, 2002·Neurobiology of Aging·R E Mrak, W S Griffin
Dec 11, 2002·Journal of the American Geriatrics Society·Craig J WilsonHarvey J Cohen
Dec 25, 2002·Neurobiology of Aging·Anne K VehmasJuan C Troncoso
Mar 22, 2003·Acta Anaesthesiologica Scandinavica·L S RasmussenUNKNOWN ISPOCD2(International Study of Postoperative Cognitive Dysfunction) Investigators
Aug 6, 2005·Progress in Neurobiology·Michelle L Block, Jau-Shyong Hong
Jan 26, 2007·Journal of Neurochemistry·Anthony LyonsMarina A Lynch
Oct 16, 2007·Neuro-degenerative Diseases·Rita João GuerreiroCatarina Oliveira
Apr 18, 2009·Anesthesia and Analgesia·Dmitri BaranovUNKNOWN First International Workshop on Anesthetics and Alzheimer's Disease

❮ Previous
Next ❯

Citations

Nov 3, 2012·International Psychogeriatrics·David A ScottLisbeth A Evered
Jan 5, 2014·British Journal of Anaesthesia·M R NadelsonM S Avidan
Feb 18, 2016·Scientific Reports·Yongli ZhangCheng-Xin Gong
Aug 12, 2014·The International Journal of Neuroscience·Yan-Hua ZhangTian-Long Wang
Apr 12, 2013·CNS Neuroscience & Therapeutics·Marc De KockPatricia Lavand'homme
Feb 6, 2016·Journal of Experimental Neuroscience·Ann D LiebertEuahna Varigos
Jul 26, 2012·European Journal of Anaesthesiology·Mohamed M Ghoneim, Robert I Block
Mar 29, 2013·CNS Neuroscience & Therapeutics·Yi WangWen Ouyang
Jun 11, 2011·Current Opinion in Anaesthesiology·Grainne Nicholson, George M Hall
Mar 25, 2014·Experimental and Therapeutic Medicine·Luyuan YuSuli Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.