Abstract
It is known that prostaglandins (PGs) modify the inflammatory reaction in concert with other biologically active mediators. However, characteristics of these interactions or modulating actions have not yet been clarified well. Recently, the production of mice with specific receptor deficiencies by using the gene targeting procedure for PG receptors has accelerated elucidation of the roles of PGs through correlation of their phenotypes and experimental features. Here I discuss roles of PGs in experimental paw edema, the writhing reaction of a pain model, and regulation of cytokine production, as determined using some PG-receptor-deficient mice. From the experiment of carrageenin-induced paw edema in IP receptor-deficient mice, with an indomethacin or bradykinin antagonist, we conclude that bradykinin initially induces paw swelling and then stimulates the release PGI2, which in turn enhances the swelling with bradykinin. By comparing the writhing responses in IP-deficient and wild-type mice, we found that PGI2 is a main mediator for this pain reaction. However, in the LPS-pretreated mice, not only PGI2 but also other PGs produced by COX-2 may be involved in pain induction. Production of TNF alpha and IL-10 was modified with PGI2 ...Continue Reading
References
Sep 1, 1989·Japanese Journal of Pharmacology·M DozenS Oh-Ishi
Apr 1, 1986·Prostaglandins, Leukotrienes, and Medicine·S OhK Yamaki
Aug 1, 1987·Agents and Actions·S Oh-ishiT Nakano
Jun 23, 1971·Nature: New Biology·J R Vane
Feb 3, 1994·European Journal of Pharmacology·I UtsunomiyaS Oh-ishi
Apr 11, 1996·European Journal of Pharmacology·S Oh-ishiY Hara
Feb 1, 1997·British Journal of Pharmacology·M AsanoM Okuhara
Aug 14, 1997·Nature·T MurataS Narumiya
Aug 26, 1998·European Journal of Pharmacology·H MatsumotoS Oh-ishi
Nov 6, 1998·Japanese Journal of Pharmacology·A UenoS Oh-ishi
Mar 2, 1999·Cytokine·I UtsunomiyaS Oh-ishi
Oct 3, 1999·Physiological Reviews·S NarumiyaF Ushikubi
Mar 29, 2000·Life Sciences·A UenoS Oh-ishi
Mar 29, 2001·Biochemical Pharmacology·Y IkedaS Oh-ishi