Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones

European Journal of Pharmacology
L C Stanfa, A H Dickenson

Abstract

Several types of metabotropic glutamate receptor are known to be located in the spinal cord. This study examined the effects of the metabotropic glutamate receptor agonists (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD), (S)-3,5-dihydroxyphenylglycine ((S)-3,5-DHPG) and (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3S)-ACPD) on the electrically evoked responses of dorsal horn neurones recorded in normal animals and in animals 3 h after the induction of carrageenan inflammation. The group I and II agonist (1S,3R)-ACPD produced facilitations of the noxious evoked neuronal responses in normal animals, but inhibited these responses following carrageenan inflammation. The group II agonist (1S,3S)-ACPD also produced inhibitions in the carrageenan animals, in contrast to the mixed effects seen in normal animals. The group I agonist (S)-3,5-DHPG produced mixed effects (inhibitions and facilitations) in both normal and carrageenan animals. This in vivo study shows that the effects of metabotropic glutamate receptor agonists are more complex than in vitro studies have suggested to date.

References

Jan 1, 1995·Neuropharmacology·J P Pin, R Duvoisin
Jun 1, 1994·Trends in Pharmacological Sciences·A DrayA Dickenson

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Citations

Jun 22, 2000·The Journal of Comparative Neurology·F J AlvarezP M Somohano
Jul 16, 2002·Pharmacology, Biochemistry, and Behavior·Rosa Maria A SimmonsSmriti Iyengar
Sep 23, 2000·Brain Research. Molecular Brain Research·F Lourenço NetoJ M Castro-Lopes
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Oct 27, 2009·The Journal of Pain : Official Journal of the American Pain Society·Hui-Sheng ChenSu-Jie Lu
Sep 25, 2012·Experimental Physiology·Maria OsikowiczBarbara Przewlocka
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Jun 19, 2002·CNS Drug Reviews·Konstanty Wiśniewski, Halina Car
Oct 26, 2018·Frontiers in Molecular Neuroscience·Mariacristina MazzitelliVolker Neugebauer

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