Inflammation, Amyloid, and Atrophy in The Aging Brain: Relationships with Longitudinal Changes in Cognition

Journal of Alzheimer's Disease : JAD
Roser Sala-LlonchAnders M Fjell

Abstract

Amyloid deposition occurs in aging, even in individuals free from cognitive symptoms, and is often interpreted as preclinical Alzheimer's disease (AD) pathophysiology. YKL-40 is a marker of neuroinflammation, being increased in AD, and hypothesized to interact with amyloid-β (Aβ) in causing cognitive decline early in the cascade of AD pathophysiology. Whether and how Aβ and YKL-40 affect brain and cognitive changes in cognitively healthy older adults is still unknown. We studied 89 participants (mean age: 73.1 years) with cerebrospinal fluid samples at baseline, and both MRI and cognitive assessments from two time-points separated by two years. We tested how baseline levels of Aβ42 and YKL-40 correlated with changes in cortical thickness and cognition. Thickness change correlated with Aβ42 only in Aβ42+ participants (<600 pg/mL, n = 27) in the left motor and premotor cortices. Aβ42 was unrelated to cognitive change. Increased YKL-40 was associated with less preservation of scores on the animal naming test in the total sample (r = -0.28, p = 0.012) and less preservation of a score reflecting global cognitive function for Aβ42+ participants (r = -0.58, p = 0.004). Our results suggest a role for inflammation in brain atrophy and c...Continue Reading

References

Sep 1, 1979·The British Journal of Social and Clinical Psychology·D C KendrickI C Moyes
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jul 1, 1997·Neurobiology of Aging·H Braak, E Braak
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Jun 22, 2000·International Journal of Geriatric Psychiatry·K I Shulman
Oct 1, 1955·Journal of Consulting Psychology·R M REITAN
Jan 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karen M Rodrigue, Naftali Raz
May 11, 2005·Archives of Neurology·James E GalvinJohn C Morris
Dec 8, 2007·Cerebral Cortex·J S DamoiseauxS A R B Rombouts
Jan 7, 2010·Cerebral Cortex·Anders M FjellUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 17, 2010·Nature Reviews. Neurology·Kaj BlennowHenrik Zetterberg
Jun 24, 2010·Neurobiology of Aging·Duygu TosunUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 27, 2010·Brain : a Journal of Neurology·Gaël ChételatUNKNOWN Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) Research Group
Sep 25, 2010·Journal of the American Geriatrics Society·Debra A FleischmanDavid A Bennett
Nov 3, 2010·Biological Psychiatry·Rebecca Craig-SchapiroDavid M Holtzman
Dec 25, 2010·Annals of Neurology·Jonathan M SchottUNKNOWN Alzheimer's Disease Neuroimaging Initiative Investigators
Mar 8, 2011·NeuroImage·Martin Reuter, Bruce Fischl
Mar 26, 2011·Annals of Neurology·J Alex BeckerKeith A Johnson
Mar 21, 2012·NeuroImage·Martin ReuterBruce Fischl
Mar 14, 2013·Journal of Alzheimer's Disease : JAD·Eider M Arenaza-UrquijoDavid Bartrés-Faz
May 10, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anders M FjellUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 20, 2014·Progress in Neurobiology·Anders M FjellUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 16, 2014·Journal of Alzheimer's Disease : JAD·Anna AntonellJosé Luis Molinuevo
Sep 26, 2014·Dementia and Geriatric Cognitive Disorders Extra·Christoffer RosénHenrik Zetterberg
Mar 21, 2015·Lancet Neurology·Michael T HenekaMarkus P Kummer
Apr 5, 2015·Trends in Pharmacological Sciences·Kaj BlennowHenrik Zetterberg
Oct 16, 2015·Neurology·Marissa D ZwanPieter J Visser
Dec 25, 2015·Alzheimer's Research & Therapy·Konstantin HellwigPhilipp Spitzer
Jan 20, 2016·Annals of Clinical and Translational Neurology·Shorena JanelidzeOskar Hansson
Feb 2, 2016·Neurobiology of Aging·Juan Domingo GispertJosé Luis Molinuevo
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Ellis NiemantsverdrietSebastiaan Engelborghs

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Citations

Oct 29, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Victor MontalJuan Fortea
Mar 12, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Isabelle BosPieter Jelle Visser
Dec 22, 2019·Brain Structure & Function·L JänckeS Merillat
Oct 23, 2019·Signal Transduction and Targeted Therapy·Pei-Pei LiuJian-Sheng Kang
Jun 14, 2019·Reviews in the Neurosciences·Jessica OschwaldSusan Mérillat
Sep 27, 2019·Respiratory Physiology & Neurobiology·Xiaoli LiuXiangrong Shi
Aug 23, 2020·Signal Transduction and Targeted Therapy·Pei-Pei LiuJian-Sheng Kang
May 4, 2021·Frontiers in Human Neuroscience·Christiane JockwitzSvenja Caspers
May 27, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Andrei IrimiaHillard Kaplan

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