Inflammation and cachexia in chronic kidney disease.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
W CheungRobert H Mak

Abstract

Chronic inflammation is associated with cachexia and increased mortality risk in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Inflammation suppresses appetite and causes the loss of protein stores. In CKD patients, increased serum levels of pro-inflammatory cytokines may be caused by reduced renal function, volume overload, oxidative or carbonyl stress, decreased levels of antioxidants, increased susceptibility to infection in uremia, and the presence of comorbid conditions. Cachexia is brought about by the synergistic combination of a dramatic decrease in appetite and an increase in the catabolism of fat and lean body mass. Pro-inflammatory cytokines act on the central nervous system to alter appetite and energy metabolism and to provide a signal-through the nuclear factor-kappaB and ATP-ubiquitin-dependent proteolytic pathways-that causes muscle wasting. Further research into the molecular pathways leading to inflammation and cachexia may lead to novel therapeutic therapies for this devastating and potentially fatal complication of chronic disease.

References

Sep 6, 1979·Nature·N J Rothwell, M J Stock
Jan 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C L LoprinziM D Jensen
Jan 22, 1993·Biochimica Et Biophysica Acta·M P ThompsonJ A Tuckey
Oct 8, 1998·Kidney & Blood Pressure Research·C Wanner, J Zimmermann
Feb 13, 1999·Kidney International·J ZimmermannC Wanner
Jun 3, 1999·Kidney International·J S WongJ T Daugirdas
Sep 3, 1999·Journal of Clinical Immunology·A F SuffrediniN P O'Grady
Dec 11, 1999·JAMA : the Journal of the American Medical Association·M VisserT B Harris
Dec 22, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·K SchärerM Soergel
Nov 23, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G ChinettiB Staels
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R C LangenY M Janssen-Heininger
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kathy E SietsemaEric P Brass
Jan 12, 2002·Kidney International·Stephen L SeligerCatherine O Stehman-Breen
Mar 29, 2002·Kidney International·Warren P PickeringJohn Walls
Apr 4, 2002·CA: a Cancer Journal for Clinicians·Akio Inui
May 7, 2002·British Journal of Anaesthesia·R C BakerW T McBride
Jun 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jai Won ChangSoon Bae Kim
Jun 11, 2002·Biochemical and Biophysical Research Communications·Josep M ArgilésFrancisco J López-Soriano
Aug 9, 2002·Nature·Michael W Schwartz, Gregory J Morton
Sep 11, 2002·Blood Purification·Marcelo M NascimentoPeter Stenvinkel
Nov 13, 2002·Kidney International·Trinh B PiferEric W Young
Dec 20, 2002·Nature·Kevin J Tracey
Apr 16, 2003·Kidney International. Supplement·Matthias GirndtHans Köhler
May 16, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Donal N ReddanEdmund G Lowrie
May 23, 2003·Journal of the American Society of Nephrology : JASN·Mohammed E SulimanPeter Stenvinkel
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Angela Yee-Moon WangJohn Sanderson

❮ Previous
Next ❯

Citations

Jan 5, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Wai W CheungRobert H Mak
Jan 14, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Emma L ClappAlice C Smith
Feb 8, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Robert H MakBethany J Foster
Aug 30, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bethany J FosterRobert H Mak
Aug 14, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Colin Farquharson, S Faisal Ahmed
Jun 15, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nur CanpolatRukshana Shroff
May 23, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chiao-Yin SunMai-Szu Wu
Aug 25, 2010·Current Opinion in Supportive and Palliative Care·Stephanie M Krasnow, Daniel L Marks
Aug 24, 2012·American Journal of Physiology. Renal Physiology·Wai W Cheung, Robert H Mak
Jun 6, 2013·International Journal of Endocrinology·Maurice DungeyNicolette C Bishop
Jun 14, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mieczysław Litwin, Anna Niemirska
Jul 2, 2014·Nature Reviews. Nephrology·Xiaonan H Wang, William E Mitch
Apr 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ibrahim H Fahal
Nov 20, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Heloisa Reniers ViannaAna Cristina Simões E Silva
Aug 25, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maria Fernanda Soares NaufelJoão Tomás de Abreu Carvalhaes
Apr 28, 2012·Nutrition & Metabolism·Adrian D Slee
Jun 10, 2015·Journal of the American Society of Nephrology : JASN·Hui PengZhaoyong Hu
Jun 11, 2011·International Journal of Nephrology·Fischbach MichelSchmitt Claus Peter
May 8, 2013·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Cynthia DelgadoKirsten L Johansen
Oct 30, 2012·Clinical Biochemistry·D Polak-JonkiszI Makulska
Jul 12, 2012·Biochemical and Biophysical Research Communications·Zhenming CaiYaping Wang
Nov 8, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Yasar CaliskanMehmet S Sever
Aug 16, 2011·Medical Hypotheses·J F SaldanhaD Mafra
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Pontus M A Siren, Matti J Siren
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Timo D MüllerMatthias H Tschöp
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Robert H MakKamyar Kalantar-Zadeh
Oct 22, 2014·Hemodialysis International·Michel FischbachJoelle Terzic
Aug 15, 2015·Sleep & Breathing = Schlaf & Atmung·Aline Rodrigues PintoLuciana Pinato
Apr 21, 2012·International Journal of Peptides·Diana R Engineer, Jose M Garcia
Apr 10, 2016·Journal of the American Society of Nephrology : JASN·Madhav C Menon, John Cijiang He
May 12, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yaacov OriHertzel Salman
Apr 15, 2015·Frontiers in Physiology·Antonia KaltsatouChristina Karatzaferi
Sep 10, 2013·Cell Metabolism·Liping ZhangWilliam E Mitch
May 15, 2013·Maturitas·Nicole EbnerStephan von Haehling
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hong YaoZhao-Guang Liang
Sep 30, 2016·International Urology and Nephrology·Najla E FarageDenise Mafra
Apr 14, 2016·CoDAS·Aline Rodrigues PintoLuciana Pinato

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.