Inflammation and cancer

Nature
Lisa M Coussens, Zena Werb

Abstract

Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. These insights are fostering new anti-inflammatory therapeutic approaches to cancer development.

References

Sep 24, 2008·Archives of Internal Medicine·Jill KoshiolOla Landgren
Jul 28, 2011·JAMA : the Journal of the American Medical Association·Mohammed OrloffCharis Eng
Oct 25, 2011·Inflammatory Bowel Diseases·Elizabeth C WickCynthia L Sears
Jan 12, 2005·The Journal of Pathology·Philip J CoatesEric G Wright
Jan 16, 2007·Archivum Immunologiae Et Therapiae Experimentalis·Markus LiebrichRichard Meyermann
Dec 7, 2007·Archivum Immunologiae Et Therapiae Experimentalis·Paweł KrawczykJacek Roliński
Oct 6, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Jacek R Wilczyński, Markus Duechler
Jul 26, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Sanjay BatraMalaya K Sahoo
Apr 22, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ana García-LafuenteJosé Alfredo Martínez
Sep 20, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·David E CochraneRoss S Feldberg
Jul 4, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Mati Ur RehmanTadamichi Shimizu
Jul 31, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Haiqiu HuangLiangli Yu
Aug 23, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Rob Hooft van Huijsduijnen, Christian Rommel
Apr 26, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nishi N Singh, Dipak P Ramji
Apr 13, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jin-Kyung KimJung Han Yoon Park
May 12, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Uta E Höpken, Armin Rehm
Jun 5, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Chun-Te WuMiao-Fen Chen
Mar 22, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Heath A Smith, Yibin Kang
May 25, 2005·Der Urologe. Ausg. A·F Vom DorpA Eisenhardt
Aug 17, 2012·International Urogynecology Journal·Joseph KellerHerng-Ching Lin
Mar 20, 2010·Archives of Toxicology·Nadiya Bakhiya, Klaus E Appel
Jul 13, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Frank J TamarkinRobert M Weiss
Aug 23, 2011·Applied Microbiology and Biotechnology·Andoni Ramirez-GarciaFernando Luis Hernando
Dec 21, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Luisa OttobriniGiovanni Lucignani
Dec 17, 2004·Cancer Immunology, Immunotherapy : CII·Madhav V Dhodapkar
Jul 27, 2005·Cancer Immunology, Immunotherapy : CII·Qing ChenSharon S Evans
May 13, 2005·Cancer Immunology, Immunotherapy : CII·Karin E de Visser, Lisa M Coussens
Oct 13, 2006·Cancer Immunology, Immunotherapy : CII·Andrea MarrariLicia Rivoltini
Jul 10, 2007·Cancer Immunology, Immunotherapy : CII·Jovanny ZabaletaAugusto C Ochoa
Oct 3, 2007·Cancer Immunology, Immunotherapy : CII·Selma UgurelJürgen C Becker
Oct 27, 2007·Cancer Immunology, Immunotherapy : CII·Sheraz YaqubKjetil Taskén
Mar 11, 2008·Cancer Immunology, Immunotherapy : CII·Lisa M ThorntonWilliam E Carson
Jun 27, 2009·Cancer Immunology, Immunotherapy : CII·Oscar J CorderoMontserrat Nogueira
Mar 25, 2010·Cancer Immunology, Immunotherapy : CII·Jing SunXue-guang Zhang
May 22, 2010·Cancer Immunology, Immunotherapy : CII·Philippe O GannonAndré Duranceau
Jul 20, 2010·Cancer Immunology, Immunotherapy : CII·Alexander J MullerGeorge C Prendergast
Aug 17, 2011·Cancer Immunology, Immunotherapy : CII·Yasuhiro Nihon-YanagiShinichi Okazumi
Aug 31, 2011·Cancer Immunology, Immunotherapy : CII·Jing-Jing WeiZuo-Hua Feng

Citations

Oct 1, 1992·The Journal of Experimental Medicine·N JonjićA Mantovani
Dec 1, 1986·Journal of Cellular Physiology·A Richmond, H G Thomas
Nov 10, 1995·The Journal of Biological Chemistry·R M StrieterD Marriott
Jul 1, 1995·The Journal of Investigative Dermatology·E FeikenL R Lund
Mar 1, 1996·Nature Medicine·J RomerK Dano
Apr 29, 1998·European Journal of Immunology·M TalmorR M Steinman
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y J KimAjit Varki
Aug 6, 1998·The Journal of Clinical Investigation·D A ArenbergR M Strieter
Nov 12, 1998·Journal of the National Cancer Institute·L M Wahl, H K Kleinman
Jun 5, 1999·Cancer Chemotherapy and Pharmacology·M OnoM Kuwano
Nov 24, 1999·The Journal of Experimental Medicine·J D HudsonD H Beach
Jan 11, 2000·International Journal of Cancer. Journal International Du Cancer·H TorisuM Kuwano
Jan 12, 2000·Oncogene·C S WilliamsR N DuBois
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Apr 25, 2000·Annual Review of Medicine·J A Baron, R S Sandler
Jun 3, 2000·Annual Review of Immunology·D Rossi, Albert Zlotnik
Sep 6, 2000·Journal of Internal Medicine·H KuperD Trichopoulos
Oct 12, 2000·Nature Cell Biology·G BergersD Hanahan
Mar 7, 2001·Lancet·Fran Balkwill, A Mantovani
Mar 10, 2001·Nature·A MüllerAlbert Zlotnik
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·Lubor BorsigAjit Varki
Mar 21, 2001·The Journal of Experimental Medicine·E Y LinJ W Pollard
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·F QianI L Weissman
Aug 9, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M A Moore
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lubor BorsigAjit Varki
Mar 9, 2002·Advances in Cancer Research·Angus G Dalgleish, Ken J O'Byrne
Mar 20, 2002·Cytokine & Growth Factor Reviews·Fran Balkwill
Mar 20, 2002·Cytokine & Growth Factor Reviews·Alain P Vicari, Christophe Caux
Mar 27, 2002·Nature Reviews. Immunology·Bernhard HomeyAlbert Zlotnik
Mar 30, 2002·Science·Lisa M CoussensLynn M Matrisian
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
May 11, 2002·Nature Reviews. Immunology·Drew M Pardoll
May 15, 2002·Immunology Letters·Aristidis MoustakasCarl Henrik Heldin
May 22, 2002·Surgical Oncology·Buckminster Farrow, B Mark Evers

Related Concepts

Tumor Cells, Uncertain Whether Benign or Malignant
Immune System
Neoplastic Processes
Anti-Inflammatory Agents
Neoplasms
Tumor Lysis Syndrome
Chemokine
Leukocytes
Pathologic Neovascularization
Neoplastic Syndromes, Hereditary

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