Inflammation and dementia: Using rheumatoid arthritis as a model to develop treatments?

Autoimmunity Reviews
Alice MasonChristopher J Edwards

Abstract

Dementia is a major international public health problem which looks set to grow as the ageing population increases. Despite large amounts of investment there has been relatively little progress in developing new therapies to combat this. There is a growing body of evidence that both local and systemic inflammation are important in dementia; with cerebral inflammation occurring secondarily to beta-amyloid plaques, raised levels of serum inflammatory molecules and cytokines being present in Alzheimer's disease patients and systemic inflammation being associated with cerebral microvasculature disease in vascular dementia. Observational studies had suggested that non-steroidal anti-inflammatory drugs may reduce the risk of dementia, but subsequent interventional studies have been disappointing. More recently some observational studies have suggested a protective effect from conventional synthetic disease modifying anti-rheumatic drugs (csDMARDS) and tumour necrosis factor inhibiting (TNFi) biological therapies. Treatments for inflammatory rheumatic diseases have previously been repurposed and used successfully in other diseases, such as TNFi for inflammatory bowel disease. There are also studies looking at the use of csDMARDs such ...Continue Reading

Citations

Mar 13, 2020·The British Journal of Dermatology·H YenC-C Chi
Dec 11, 2019·Scientific Reports·Anatoly L Mayburd, Ancha Baranova
Dec 14, 2018·Frontiers in Cellular Neuroscience·Thomas M PiersJennifer M Pocock
Jun 15, 2020·Rheumatology and Therapy·May N LwinChristopher J Edwards
Nov 13, 2020·The Journal of Dermatology·Tsung-Hsien ChangMu-Hong Chen
Feb 21, 2021·Autoimmunity Reviews·Fabiana Assunta FigusAnnamaria Iagnocco
Mar 16, 2021·Journal of Alzheimer's Disease : JAD·Rebecca ZingelKarel Kostev
Sep 15, 2020·Journal of Neuroimmunology·Megan K LowtherE Sherwood Brown
Sep 28, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Chunlei ZhengRong Xu
Jun 12, 2020·Current Neuropharmacology·Kim San Tang

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