Abstract
Inflammation is related to many stages of atherosclerosis, and inflammatory markers have been associated with both atherosclerosis and future cardiovascular events. Descending thoracic aortic calcification (DTAC) is a manifestation of atherosclerosis, however, no previous study has examined the relationship of inflammatory markers and DTAC as detected by computed tomography (CT) in a large study. We examined whether C-reactive protein (CRP) and interleukin-6 (IL-6) are independently associated with DTAC. The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective cohort study that includes 6814 women and men ages 45-84 years old, all free of baseline cardiovascular disease. The inflammation markers CRP and IL-6, and DTAC by CT, quantified by Agatston score, were measured at baseline in all participants. We studied 6613 participants with complete data (3112 men, 3501 women, mean age 62+/-10 years). The prevalence of DTAC was 27%. Participants with DTAC had significantly higher levels of both CRP and IL-6. After adjustment for baseline risk factors, CRP was not correlated with presence or severity of DTAC (Adjusted RR per S.D., 1.01; 95% confidence intervals 0.97; 1.05) while IL-6 associations remained significant (adjusted...Continue Reading
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