Inflammation and descending thoracic aortic calcification as detected by computed tomography: the Multi-Ethnic Study of Atherosclerosis

Atherosclerosis
Junichiro TakasuMatthew J Budoff

Abstract

Inflammation is related to many stages of atherosclerosis, and inflammatory markers have been associated with both atherosclerosis and future cardiovascular events. Descending thoracic aortic calcification (DTAC) is a manifestation of atherosclerosis, however, no previous study has examined the relationship of inflammatory markers and DTAC as detected by computed tomography (CT) in a large study. We examined whether C-reactive protein (CRP) and interleukin-6 (IL-6) are independently associated with DTAC. The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective cohort study that includes 6814 women and men ages 45-84 years old, all free of baseline cardiovascular disease. The inflammation markers CRP and IL-6, and DTAC by CT, quantified by Agatston score, were measured at baseline in all participants. We studied 6613 participants with complete data (3112 men, 3501 women, mean age 62+/-10 years). The prevalence of DTAC was 27%. Participants with DTAC had significantly higher levels of both CRP and IL-6. After adjustment for baseline risk factors, CRP was not correlated with presence or severity of DTAC (Adjusted RR per S.D., 1.01; 95% confidence intervals 0.97; 1.05) while IL-6 associations remained significant (adjusted...Continue Reading

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Citations

Feb 6, 2010·Journal of Atherosclerosis and Thrombosis·Yukihiko MomiyamaFumitaka Ohsuzu
Apr 23, 2014·Journal of Cardiovascular Medicine·Jung Hye SungErvin R Fox
Nov 7, 2013·European Heart Journal·Hagen KälschUNKNOWN Heinz Nixdorf Recall Study Investigative Group
Aug 6, 2014·Cardiology Clinics·Swapnesh Parikh, Matthew J Budoff
Oct 4, 2012·Current Opinion in Cardiology·Raashid Luqmani
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Jun 28, 2015·Bone·Pawel SzulcUNKNOWN Study of Osteoporotic Fractures (SOF) Research Group
Aug 10, 2010·The American Journal of Cardiology·Mouaz H Al-MallahMatthew J Budoff
Jul 28, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kunwu YuQiutang Zeng
Nov 17, 2015·Heart Failure Clinics·Swapnesh Parikh, Matthew J Budoff
Jun 24, 2017·Journal of Bone and Mineral Metabolism·Dailin WeiTie Zhang
Jan 7, 2021·Toxins·Nikolaos C KyriakidisPeter Stenvinkel
Mar 6, 2021·The American Journal of Cardiology·Olufunmilayo H ObisesanMichael J Blaha

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