Inflammation and disease activity are associated with high circulating cardiac markers in rheumatoid arthritis independently of traditional cardiovascular risk factors

The Journal of Rheumatology
Jérôme AvouacYannick Allanore

Abstract

To measure concentrations of high-sensitivity cardiac troponin (HS-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with rheumatoid arthritis (RA) and to examine correlates. The plasma concentrations of HS-cTnT and NT-proBNP were measured in consecutive patients with RA and compared to values obtained from age-matched and sex-matched healthy controls. We included 236 unrelated patients with RA (192 females, 57 ± 13 yrs) and 213 controls (170 females, 55 ± 15 yrs). Seventy-one patients with RA were free of cardiovascular (CV) risk factors. HS-cTnT and NT-proBNP concentrations were significantly higher in the total cohort of patients with RA (p = 0.03 and p < 0.0001, respectively) and in the subgroup free of CV risk factors (p = 0.02 and p < 0.0001, respectively) compared to controls. In addition, both the total cohort of patients with RA and the subgroup free of CV risk factors were more likely to have levels above the cutoff concentrations of HS-cTnT (p = 0.003 and p = 0.007, respectively) and NT-proBNP (p = 0.0001 and p < 0.0001, respectively) than controls. Patients with RA and increased C-reactive protein (CRP) levels had higher HS-cTnT (p = 0.03) and NT-proBNP (p = 0.02) concentrations. HS-cTnT lev...Continue Reading

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Citations

Aug 2, 2013·Annals of the Rheumatic Diseases·George S MetsiosYiannis Koutedakis
Mar 17, 2016·Autoimmunity Reviews·Zoltán SzekaneczYehuda Shoenfeld
Sep 11, 2016·Trends in Cardiovascular Medicine·Katherine P Liao
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Aug 3, 2018·Cardiovascular Ultrasound·Bożena Targońska-StępniakMaria Majdan
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Dec 20, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Yuvreet KaurDavid Meyre
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Jun 17, 2020·The Journal of Rheumatology·Hélène VergneaultJérôme Avouac
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May 25, 2020·Journal of Cardiac Failure·Merry L LindseyFrancis G Spinale
Feb 20, 2021·Arthritis & Rheumatology·Jérôme AvouacYannick Allanore

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