Inflammation and hearing status in mid-childhood and mid-life: a population-based cross-sectional study

International Journal of Epidemiology
Jing WangMelissa Wake

Abstract

Lifelong inflammation - known to be associated with many non-communicable diseases - has not been thoroughly investigated in hearing. We aimed to determine if glycoprotein A (GlycA), a novel biomarker of chronic inflammation, is associated with hearing acuity in mid-childhood and mid-life. Population-based cross-sectional study within the Longitudinal Study of Australian Children with plasma GlycA and audiometry data (1169 children and 1316 parents). We calculated high Fletcher Index (mean threshold across 1, 2 and 4 kHz), defining hearing loss as threshold >15 decibel hearing level (dB HL) (better ear). Linear/logistic regression quantified associations of GlycA with hearing threshold/loss. Mean [standard deviation (SD)] high Fletcher Indices (dB HL) were 8.0 (5.7) for children and 13.1 (6.9) for adults, with 8.7% and 26.1% respectively showing hearing loss. 1-SD rise in GlycA (children 0.13 mmol/L, adults 0.17 mmol/L) predicted higher hearing thresholds for the lower individual frequencies [1 kHz: children β 0.8, 95% confidence interval (CI) 0.3-1.3; adults β 0.8, 95% CI 0.2-1.4]. This same pattern was evident for the high Fletcher Index (children β 0.7, 95% CI 0.3-1.1; adults β 0.8, 95% CI 0.3-1.4). This translated into 1-SD...Continue Reading

References

Feb 1, 1993·Archives of Otolaryngology--head & Neck Surgery·G A GatesP A Wolf
Apr 18, 1998·JAMA : the Journal of the American Medical Association·A S NiskarD J Brody
Jun 15, 1999·Archives of Otolaryngology--head & Neck Surgery·G A GatesR H Myers
Sep 21, 2000·British Journal of Audiology·UNKNOWN MRC Multi-centre Otitis Media Study Group
Jun 29, 2007·Physiology & Behavior·Marianne SchultzbergMircea Oprica
Aug 12, 2008·Ageing Research Reviews·Hae Young ChungChristiaan Leeuwenburgh
Nov 26, 2009·Biological Research for Nursing·Katherine J HuntHelen C Roberts
Aug 19, 2010·JAMA : the Journal of the American Medical Association·Josef ShargorodskyRoland Eavey
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Elias Q SchererSteffen-Sebastian Bolz
Mar 2, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Frank R LinLuigi Ferrucci
Feb 14, 2012·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Robert J Teunisse, Marcel G M Olde Rikkert
Jan 17, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Annie N SimpsonJudy R Dubno
Jun 7, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Scott D NashTheodore S Tweed
Jun 12, 2013·The Laryngoscope·Anil K LalwaniMichael Weitzman
Apr 1, 2014·International Journal of Audiology·Carl VerschuurTracey A Newman
Mar 18, 2015·Clinical Chemistry·James D OtvosRussell P Tracy
Dec 9, 2015·International Journal of Audiology·Bo EngdahlKristian Tambs
Apr 28, 2017·Frontiers in Cellular Neuroscience·Megan B Wood, Jian Zuo
May 12, 2017·Journal of Epidemiology and Community Health·Richard S LiuDavid P Burgner
Jul 28, 2017·JAMA Otolaryngology-- Head & Neck Surgery·Carlijn M P le ClercqMarc P van der Schroeff
Oct 29, 2017·Journal of Translational Medicine·Margery A ConnellyNehal N Mehta

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Citations

Dec 18, 2020·Frontiers in Neurology·Paola PerinCinzia Boselli

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