Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets

Seminars in Liver Disease
Yoon Mee YangEkihiro Seki

Abstract

Hepatocellular carcinoma (HCC) is associated with chronic inflammation and fibrosis arising from different etiologies, including hepatitis B and C and alcoholic and nonalcoholic fatty liver diseases. The inflammatory cytokines tumor necrosis factor-α and interleukin-6 and their downstream targets nuclear factor kappa B (NF-κB), c-Jun N-terminal kinase (JNK), and signal transducer and activator of transcription 3 drive inflammation-associated HCC. Further, while adaptive immunity promotes immune surveillance to eradicate early HCC, adaptive immune cells, such as CD8+ T cells, Th17 cells, and B cells, can also stimulate HCC development. Thus, the role of the hepatic immune system in HCC development is a highly complex topic. This review highlights the role of cytokine signals, NF-κB, JNK, innate and adaptive immunity, and hepatic stellate cells in HCC and discusses whether these pathways could be therapeutic targets. The authors will also discuss cholangiocarcinoma and liver metastasis because biliary inflammation and tumor-associated stroma are essential for cholangiocarcinoma development and because primary tumor-derived inflammatory mediators promote the formation of a "premetastasis niche" in the liver.

Citations

May 1, 2020·International Journal of Molecular Sciences·Manuela LabbozzettaPaola Poma
Oct 18, 2019·Cancers·Quirino LaiUNKNOWN Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group
Jun 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·De-Ling WuLing-Yi Kong
Jun 18, 2020·Cancer Management and Research·Aiqing Ma, Rui Zhang
Sep 17, 2019·Molecular Medicine Reports·Xinxin ZengZhaoxu Li
Dec 1, 2020·Technology in Cancer Research & Treatment·Cuimeng TianJi Ming Wang
Dec 2, 2020·International Journal of Molecular Sciences·Pradeep Kumar RajanJuan Sanabria
Sep 7, 2020·Pharmacology & Therapeutics·Anna FishbeinDipak Panigrahy
Jan 20, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Suhuan MeiXiumin Chen
Apr 19, 2020·International Immunopharmacology·Abdullah Al MamunJian Xiao
Nov 16, 2020·Gastroenterology·Alain P GobertKeith T Wilson
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kailong WangHaiyang Yu
Jan 22, 2021·Molecular Therapy. Methods & Clinical Development·Rita FerlaAlberto Auricchio
Feb 9, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dhwanil A DalwadiWillscott E Naugler
Jan 31, 2021·International Journal of Molecular Sciences·Elisabeth DigificoCristina Belgiovine
Dec 29, 2020·Phytotherapy Research : PTR·Venkatasubramanian AishwaryaVenkatabalasubramanian Sivaramakrishnan
Nov 15, 2019·Current Topics in Medicinal Chemistry·Sachin KumarHimangini Bansal
Feb 15, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Zhichao FengWei Wang
Nov 17, 2020·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Fanyun KongRenxian Tang
May 1, 2021·Antioxidants·Gregori CasalsWladimiro Jiménez
Dec 1, 2020·Pharmacology & Therapeutics·Bingjian WenZhengquan Su
May 11, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Markus Bo SchoenbergAlexandr V Bazhin
May 8, 2021·Cellular and Molecular Gastroenterology and Hepatology·Shunjie XiaXiujun Cai
May 19, 2021·Journal of Viral Hepatitis·Ferhat ArslanPasquale Pagliano
Jul 2, 2021·Analytical Cellular Pathology (Amsterdam)·Yu-Gui ZhangXing-Ke Yan
Jul 3, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Devy Maulidya CahyaniRetno Sari
Sep 3, 2021·Environmental Toxicology·Gopalakrishnan BalaramanDevaki Thiruvengadam
Sep 19, 2021·Cancer Cell International·Ahmed OlatundeJavad Sharifi-Rad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Related Papers

Current Pathobiology Reports
Yoon Mee Yang, Ekihiro Seki
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Ekihiro Seki, Robert F Schwabe
Gastroenterology
Fabio Marra, Frank Tacke
© 2022 Meta ULC. All rights reserved