Jul 1, 2020

Inflammation and Mitochondrial Dysfunction in Autism Spectrum Disorder

CNS & Neurological Disorders Drug Targets
Maria GevezovaMichael Maes

Abstract

Autism Spectrum Disorders (ASD) is a severe childhood psychiatric condition with an array of cognitive, language and social impairments that can significantly impact on family life. ASD is classically characterized by reduced communication skills and social interactions, with limitations imposed by repetitive patterns of behavior, interests, and activities. The pathophysiology of ASD is thought to arise from complex interactions between environmental and genetic factors within the context of individual development. A growing body of research has raised the possibility of identifying the aetiological causes of the disorder. This review highlights the roles of immune-inflammatory pathways, nitro-oxidative stress and mitochondrial dysfunctions in ASD pathogenesis and symptom severity. The role of NK-cells, T helper, T regulatory and B-cells, coupled to increased inflammatory cytokines, lowered levels of immune-regulatory cytokines, and increased autoantibodies and microglial activation is elucidated. It is proposed that alterations in mitochondrial activity and nitro-oxidative stress are intimately associated with activated immune-inflammatory pathways. Future research should determine as to whether the mitochondria, immune-inflam...Continue Reading

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Mentioned in this Paper

Taurine
Immune Cell Activation During Inflammatory Response
Inflammatory Response Pathway
Vitamin D
Cytokine
Array
Oxytocin
Pathogenesis
Research
Suramin

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