Inflammation and Neoplasia of the Pouch in Inflammatory Bowel Disease

Current Gastroenterology Reports
Freeha Khan, Bo Shen

Abstract

Ileal pouch-anal anastomosis (IPAA) is the standard restorative procedure after proctocolectomy in patients with inflammatory bowel disease who require colectomy. The ileal pouch is susceptible to a variety of adverse outcomes including mechanical insult, ischemia, and infectious agents. There is also a risk for developing low-grade dysplasia (LGD), high-grade dysplasia (HGD), or even adenocarcinoma in the pouch. The purpose of this review is to highlight risk factors, clinical presentation, surveillance, and treatment of pouch neoplasia. Patients with pre-colectomy colitis-associated neoplasia are at high risk for developing pouch neoplasia. Other purported risk factors include the presence of family history of colorectal cancer, the presence of concurrent primary sclerosing cholangitis, chronic pouchitis, cuffitis, or Crohn's disease of the pouch. Pouch adenocarcinoma tends to have a poor prognosis. It is recommended to have a combined clinical, endoscopic, and histologic approach in diagnosis and management. Surveillance and management algorithms of pouch neoplasia are proposed, based on the risk stratification.

References

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Citations

Mar 28, 2020·United European Gastroenterology Journal·Manuel Barreiro-de AcostaJ Enrique Domínguez-Muñoz
Apr 16, 2020·Arquivos De Gastroenterologia·Rocío SedanoRodrigo Quera
Nov 4, 2020·Intestinal research·Shintaro AkiyamaDavid T Rubin

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