Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications

Cells
Jens Staal, Rudi Beyaert

Abstract

Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and benign. Due to its high prevalence, it is, however, still the second most common cause of death by cancer in men in the West. The higher prevalence of prostate cancer in the West might be due to elevated inflammation from metabolic syndrome or associated comorbidities. NF-κB activation and many other signals associated with inflammation are known to contribute to prostate cancer malignancy. Inflammatory signals have also been associated with the development of castration resistance and resistance against other androgen depletion strategies, which is a major therapeutic challenge. Here, we review the role of inflammation and its link with androgen signaling in prostate cancer. We further describe the role of NF-κB in prostate cancer cell survival and proliferation, major NF-κB signaling pathways in prostate cancer, and the crosstalk between NF-κB and androgen receptor signaling. Several NF-κB-induced risk factors in prostate cancer and their potential for therapeutic targeting in the clinic are described. A better understanding of the inflammatory mechanisms that control the development of prostate cancer and resistance to androgen-deprivati...Continue Reading

References

May 26, 1967·Science·C Huggins
Sep 27, 1996·The Journal of Biological Chemistry·J J PalvimoO A Jänne
Jun 3, 2000·Human Pathology·L BubendorfM J Mihatsch
Aug 15, 2003·International Journal of Cancer. Journal International Du Cancer·Sophie Lebel-BinayFranck Pagès
Dec 12, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Atcharaporn PongtippanElvio G Silva
Mar 30, 2004·Clinical Prostate Cancer·Charles W Yowell, Yehia Daaka
Jan 7, 2005·Clinical Prostate Cancer·Ta-Chun Yuan, Ming-Fong Lin
May 7, 2005·EMBO Reports·Isabel García-CaoManuel Serrano
Jun 16, 2005·Science's STKE : Signal Transduction Knowledge Environment·Debajit K BiswasJ Dirk Iglehart
Jul 29, 2005·International Journal of Cancer. Journal International Du Cancer·Josh D SilvertownJeffrey A Medin
Oct 26, 2005·The Prostate·Varsha KaushalPerkins Mukunyadzi
Mar 15, 2006·Biochemical and Biophysical Research Communications·Jian LiuMichael Steiner
Jun 22, 2006·The Journal of Biological Chemistry·Patrick KellyPatrick J Casey
Sep 28, 2006·The Journal of Biological Chemistry·Claudia WietekLuke A J O'Neill
Nov 16, 2006·JAMA : the Journal of the American Medical Association·Rebecca A MiksadAmiel Cooper
May 10, 2007·International Journal of Cancer. Journal International Du Cancer·Thomas NeliusOlga V Volpert
May 12, 2007·Journal of Cellular Biochemistry·Robert D LobergKenneth J Pienta
Mar 18, 2008·Molecular Cancer Research : MCR·Yi LuJian Zhang
Apr 5, 2008·International Journal of Cancer. Journal International Du Cancer·Yi CaiChawnshang Chang
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Aug 30, 2008·Molecular Carcinogenesis·Liqing XiaoMarcelo G Kazanietz
Sep 13, 2008·The Veterinary Journal·Bruce E Leroy, Nicole Northrup
Jan 23, 2009·Cell Research·Jean-François ClémentMarc J Servant
Jan 24, 2009·Cell Cycle·Marianna TraniMarene Landström
Aug 4, 2009·International Journal for Equity in Health·Gunilla RisbergKatarina Hamberg

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Citations

Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yasuyoshi MiyataHideki Sakai
Aug 14, 2020·The FEBS Journal·Jens StaalRudi Beyaert
Dec 11, 2019·International Journal of Molecular Sciences·Roberto BenelliNicoletta Ferrari
Sep 3, 2020·International Journal of Molecular Sciences·Kamila DomińskaAgnieszka Wanda Piastowska Ciesielska
Apr 17, 2019·Molecular and Cellular Biochemistry·Xueyi WuLizhi Wang
Oct 21, 2020·Cancers·Maddison ArcherNatasha Kyprianou
Nov 21, 2020·Journal of the American College of Nutrition·Saptadip Samanta
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kamran WaidhaJacob Gopas
Aug 20, 2021·Scientific Reports·Menka KhoobchandaniKattesh V Katti

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Methods Mentioned

BETA
ubiquitination
PMA
nucleotide exchange

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