PMID: 26329416Sep 4, 2015Paper

Inflammation and Oral Cancer: An Update Review on Targeted Therapies

The Journal of Contemporary Dental Practice
Gargi S SarodeDominic Augustine

Abstract

In the recent past, numerous inflammation-mediated molecular pathways have been explored and studied as important events in carcinogenesis with respect to oral squamous cell carcinoma (OSCC). These pathways are engaged in numerous stages during tumorigenesis; which includes processes, like initiation, promotion, malignant conversion, invasion and metastasis. The inflammation-mediated/related carcinogenesis pathways reported in OSCC involves COX-2, epidermal growth factor receptor (EGFR), p38a MAP kinase, NF-kB, STAT, RhoC, PPARy, etc. Many researchers are trying to target these pathways to explore more effective therapeutic interventions in OSCC. The aim of the present paper is to briefly discuss these pathways, with special emphasis on the therapeutic utilities. The therapeutic targets for the aforementioned pathways were searched in databases pubmed and scopus with no restriction to date of publication. Articles published in English medical literature on OSCC were selected for discussion. The recent combinations, modifications in dosage and frequency, or the use of new anti-inflammatory compounds, may exemplify the next generation care for OSCC.

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Citations

Nov 20, 2016·British Dental Journal·A O Salgado-PeralvoA Salgado-García
Dec 10, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sachin C SarodeShankargouda Patil
Sep 14, 2019·Tobacco Induced Diseases·Mohammed E A Mohammed, Eid I Brima
Jan 14, 2017·Frontiers in Physiology·Cong GuoYan-Dong Wang
Sep 25, 2019·Surgical Oncology·Lian LiuJunhui Huang
May 22, 2016·The Journal of Contemporary Dental Practice·Gargi S SarodeRahul Anand

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