Inflammation and oxidative stress markers in diabetes and hypertension

Journal of Inflammation Research
Chloé PouvreauH F Jelinek

Abstract

Inflammation and oxidative stress are important factors associated with chronic disease such as essential hypertension (HTN) and type 2 diabetes mellitus (T2DM). However, the association of inflammation and oxidative stress in HTN with T2DM as a comorbidity is inconclusive due to the multifactorial nature of these cardiometabolic diseases. The influence of pathophysiological factors include genetics, age of patient, and disease progression change throughout the lifespan and require further investigation. The study population included 256 participants attending a rural health screening program who were tested for markers of inflammation, oxidative stress, and coagulation/fibrinolysis. Demographic and clinical variables included, age, gender, systolic and diastolic blood pressures, blood glucose, hemoglobin A1c, estimated glomerular filtration rate, and cholesterol profile. Data were tested for normality, and nonparametric statistics were applied to analyze the sample with significance set atp<0.05. Of the inflammatory markers, interleukin-1β (IL-1β) and IL-10 were significantly different between the control and hypertensive group (p<0.03) and between the HTN+T2DM compared to the HTN group (p<0.05). Significant results for oxidat...Continue Reading

Citations

Jun 12, 2020·Therapeutic Advances in Endocrinology and Metabolism·Yan LuQiang Wang
Sep 27, 2020·The Journal of Clinical Endocrinology and Metabolism·Xiaoli WangYu Xu
Oct 8, 2020·Nutrients·Juan SalazarValmore Bermudez
Sep 29, 2019·Journal of Ethnopharmacology·Marzia VasarriDonatella Degl'Innocenti
Feb 11, 2021·International Journal of Molecular Sciences·Antonio ManciniAndrea Silvestrini
Oct 16, 2020·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Grainne ScanlonJames Loughman
Jan 28, 2021·Journal of Diabetes Investigation·Sarai Sánchez-DuarteElizabeth Sánchez-Duarte
May 14, 2021·Frontiers in Pharmacology·Bahare SalehiJavad Sharifi-Rad

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Methods Mentioned

BETA
ELISA
Assay
pharmacotherapy

Software Mentioned

SPSS

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