Inflammation and Parkinson's disease pathogenesis: Mechanisms and therapeutic insight

Progress in Molecular Biology and Translational Science
Gianluigi ForloniClaudia Balducci

Abstract

After Alzheimer's disease, Parkinson's disease is the most frequent neurodegenerative disorder. Although numerous treatments have been developed to control the disease symptomatology, with some successes, an efficacious therapy affecting the causes of PD is still a goal to pursue. The genetic evidence and the identification of α-synuclein as the main component of intracellular Lewy bodies, the neuropathological hallmark of PD and related disorders, have changed the approach to these disorders. More recently, the detrimental role of α-synuclein has been further extended to explain the wide spread of cerebral pathology through its oligomers. To emphasize the central pathogenic role of these soluble aggregates, we have defined synucleinopathies and other neurodegenerative disorders associated with protein misfolding as oligomeropathies. Another common element in the pathogenesis of oligomeropathies is the role played by inflammation, both at the peripheral and cerebral levels. In the brain parenchyma, inflammatory reaction has been considered an obvious consequence of neuronal degeneration, but recent observations indicate a direct contribution of glial alteration in the early phase of the disease. Furthermore, systemic inflammati...Continue Reading

Related Concepts

Alzheimer's Disease
Objective (Goal)
Inflammation
Chronic Inflammation
Nerve Degeneration
Neuroglia
Parkinson Disease
Pathologic Processes
Amyloid beta-Peptides
Tau Proteins

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