Inflammation and Symptom Change in Interstitial Cystitis or Bladder Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study

Urology
Andrew SchrepfSusan Lutgendorf

Abstract

To explore inflammatory factors that influence symptom changes in interstitial cystitis or bladder pain syndrome (IC or BPS). This longitudinal, prospective study examined the association of inflammation elicited by Toll-like receptor (TLR) stimulation in peripheral blood mononuclear cells (PBMCs) and diurnal cortisol rhythms with changes in painful and urinary symptoms of IC or BPS and symptom flares over a 48-week period. Participants were 24 women meeting criteria for IC or BPS who supplied blood for isolation of PBMCs and 3 days of salivary cortisol samples prior to a baseline visit. Participants completed the Genitourinary Pain Index (pain and urinary subscales) and reported symptom flares every 2 weeks for 48 weeks. Mixed effects longitudinal and regression models were used to determine if inflammatory variables were associated with the changes in IC or BPS symptoms (time × variable interactions), and the probability of a symptom flare. Elevated TLR-4 inflammation (P = .031) and elevated TLR-2 inflammation (P = .045) from PBMCs, and flattened diurnal cortisol slope (P = .012) were each associated with less improvement in genitourinary pain over time. Additionally, elevated TLR-4 inflammation was associated with less impro...Continue Reading

References

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Jun 8, 2014·Pain·Andrew SchrepfUNKNOWN Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
Aug 3, 2014·BMC Urology·J Quentin ClemensUNKNOWN MAPP Research Network Study Group
Aug 3, 2014·BMC Urology·J Richard LandisUNKNOWN MAPP Research Network Study Group
Mar 17, 2015·Brain, Behavior, and Immunity·Andrew SchrepfUNKNOWN Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
Mar 21, 2015·International Urogynecology Journal·Siobhan SutcliffeSandra H Berry

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Citations

May 3, 2018·American Journal of Physiology. Renal Physiology·Mariana G de OliveiraEdson Antunes
Dec 19, 2018·Nature Reviews. Urology·J Quentin ClemensUNKNOWN MAPP Research Network Study Group
Nov 2, 2018·Clinical Obstetrics and Gynecology·Sara R TillAndrew Schrepf
Sep 14, 2018·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Andrew SchrepfUNKNOWN MAPP Research Network
Oct 9, 2020·Journal of Cellular and Molecular Medicine·Xin WangQingjiang Jin
Nov 24, 2020·International Immunopharmacology·Xin WangQingjiang Jin
Mar 20, 2020·Current Opinion in Behavioral Sciences·Bianka KarshikoffIhssane Zouikr
Jun 2, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Larissa Ramalho Dantas Varella DutraMaria Thereza Babosa Albuquerque Cabral Micussi

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