Inflammation and the coagulation system in tuberculosis: Tissue Factor leads the dance

European Journal of Immunology
Nadia Caccamo, Francesco Dieli

Abstract

Mycobacterium tuberculosis, the causative agent of tuberculosis, drives the formation of granulomas, structures in which both immune cells and the bacterial pathogen cohabit. The most abundant cells in granulomas are macrophages, which contribute as both cells with bactericidal activity and as targets for M. tuberculosis infection and proliferation during the entire course of infection. The mechanisms and factors involved in the regulation and control of macrophage microenvironment-specific polarization and plasticity are not well understood, as some granulomas are able to control bacteria growth and others fail to do so, permitting bacterial spread. In this issue of the European Journal of Immunology, Venkatasubramanian et al. [Eur. J. Immunol. 2016. 46: 464-479] show that mice lacking the tissue factor gene in myeloid cells have augmented M. tuberculosis growth and increased inflammation in the lungs. This suggests that tissue factor, an initiator of coagulation, is important for the generation of fibrin, which supports granuloma formation. This article demonstrates for the first time the involvement of tissue factor in inducing effective immunity against M. tuberculosis, and sheds new lights on the complex interplay between ...Continue Reading

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Citations

Sep 9, 2016·Immunotherapy·Nancy GuptaRakesh Kumar
Nov 7, 2019·Apoptosis : an International Journal on Programmed Cell Death·Yun-Ji LimChang-Hwa Song
Jun 12, 2018·BioMed Research International·Shouquan WuJian-Qing He
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Dec 29, 2020·Tuberculosis·Reema BansalAmod Gupta
Aug 10, 2021·Frontiers in Immunology·Xueying ZhangJincheng Zeng

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