Inflammation as a central mechanism in Alzheimer's disease

Alzheimer's & Dementia : Translational Research & Clinical Interventions
Jefferson KinneyB Lamb

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaques and neurofibrillary tangles. Over the last decade, the presence of a sustained immune response in the brain has emerged as a third core pathology in AD. The sustained activation of the brain's resident macrophages (microglia) and other immune cells has been demonstrated to exacerbate both amyloid and tau pathology and may serve as a link in the pathogenesis of the disorder. In the following review, we provide an overview of inflammation in AD and a detailed coverage of a number of microglia-related signaling mechanisms that have been implicated in AD. Additional information on microglia signaling and a number of cytokines in AD are also reviewed. We also review the potential connection of risk factors for AD and how they may be related to inflammatory mechanisms.

References

May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M D WeingartenM W Kirschner
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J D BuxbaumP Greengard
Feb 1, 1992·Neurology·Patrick L McGeer, J Rogers
Aug 19, 1991·Neuroscience Letters·H FillitG Wolf-Klein
Jan 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·H J BiloA J Donker
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D GoldgaberD C Gajdusek
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W S GriffinC Araoz
Jun 1, 1989·Brain Research Bulletin·J A GlennW E Thomas
Nov 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Patrick L McGeerEdith G McGeer
Mar 10, 1988·Neuroscience Letters·M B GraeberG W Kreutzberg
Nov 10, 1982·The Journal of Comparative Neurology·J B Brierley, A W Brown
Jan 1, 1994·Clinical and Diagnostic Laboratory Immunology·C C ChaoP K Peterson
Aug 1, 1995·Human Pathology·Robert E MrakW S Griffin
Jan 1, 1995·Neurology·J B RichJ Brandt
Mar 1, 1995·Journal of Neuropathology and Experimental Neurology·W S GriffinRobert E Mrak
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·A D AlonsoK Iqbal
Jan 1, 1994·Annual Review of Neuroscience·Dennis J Selkoe
Sep 1, 1993·Journal of Neuroimmunology·E G GutierrezA J Kastin
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J BusciglioB A Yankner
Sep 1, 1995·Brain Research. Brain Research Reviews·Patrick L McGeer, Edith G McGeer
Jul 1, 1995·Neuroimmunomodulation·W A BanksR D Broadwell
Feb 13, 1997·Nature·J F BazanT J Schall
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·B KaltschmidtC Kaltschmidt
Aug 5, 1998·Journal of Neuropathology and Experimental Neurology·J G ShengW S Griffin
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·J K HarrisonL Feng
Feb 5, 1999·Progress in Brain Research·Heiko BraakE Braak
Jun 11, 1999·The American Journal of Pathology·M StalderMathias Jucker
Jul 15, 1999·JAMA : the Journal of the American Medical Association·M N HaanLewis H Kuller
Aug 14, 1999·Journal of Neuropathology and Experimental Neurology·C A WilsonVirginia M-Y Lee
Dec 22, 1999·Neurology·A OttM M Breteler
Jun 20, 2000·Neurobiology of Aging·H AkiyamaTony Wyss-Coray
Feb 28, 2001·Obesity Research·L RoytblatS Gelman
Oct 2, 2001·Neurochemistry International·Eliezer MasliahTony Wyss-Coray
Nov 8, 2001·Trends in Immunology·H UmeharaT Imai
Jan 5, 2002·Neurobiology of Aging·R T PerryR C Go
Jan 5, 2002·Cellular and Molecular Life Sciences : CMLS·Suzanne M de la MonteJack R Wands
May 10, 2002·The American Journal of Pathology·Paula Grammas, Roma Ovase
Jul 12, 2002·Journal of Neuroscience Research·Yong B LeeSeung U Kim
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tony Wyss-CorayEliezer Masliah
Aug 28, 2002·American Journal of Epidemiology·Joan LindsayIan McDowell
Jan 9, 2003·Bioorganic & Medicinal Chemistry·Masanori TobeHideya Hayashi
Mar 7, 2003·Journal of Neuroimmunology·Geraldine FlynnDavid Male
Apr 18, 2003·Genes and Immunity·Domenico LioCalogero Caruso
May 21, 2003·Archives of Neurology·Angela L GuillozetM Marsel Mesulam
Jun 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·S FlemingerA Giora
Jul 10, 2003·Brain Research·Tetsuya MizunoAkio Suzumura
Aug 5, 2003·The Journal of Clinical Investigation·Jason L EriksenTodd E Golde
Aug 20, 2003·The Journal of Experimental Medicine·Juha PalonevaLeena Peltonen
Jul 1, 1960·The Journal of Clinical Investigation·R S YALOW, S A BERSON
Jan 30, 2004·Diabetes·Juliette JansonPeter C Butler
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rena LiYong Shen
Mar 17, 2004·Molecular and Cellular Neurosciences·Susanne A KuhnHelmut Kettenmann
Mar 27, 2004·Physiological Reviews·Jesus AvilaFelix Hernandez
Mar 31, 2004·Experimental Cell Research·Rodrigo A QuintanillaRicardo B Maccioni
Apr 3, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kumar SambamurtiD K Lahiri
Sep 21, 2004·Journal of Neuroscience Research·Anirban BasuSteven W Levison
Oct 12, 2004·The International Journal of Biochemistry & Cell Biology·Ehab E Tuppo, Hugo R Arias
Nov 27, 2004·European Archives of Psychiatry and Clinical Neuroscience·Harald HampelHans-Jürgen Möller
Feb 1, 2005·Annals of the New York Academy of Sciences·Masashi KitazawaFrank M LaFerla
Mar 5, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Lisa Mosconi
May 17, 2005·Nature Neuroscience·Dimitrios DavalosWen-Biao Gan
Sep 30, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masashi KitazawaFrank M LaFerla
Dec 20, 2005·Lancet Neurology·Geert Jan BiesselsPhilip Scheltens
Feb 14, 2006·The American Journal of Clinical Nutrition·W Sue T Griffin
Apr 22, 2006·Journal of Alzheimer's Disease : JAD·Nataniel Lester-CollSuzanne M de la Monte
May 16, 2006·Neurobiology of Aging·Patrick L McGeer, Edith G McGeer
May 30, 2006·Nature Neuroscience·Astrid CardonaRichard M Ransohoff
Sep 6, 2006·Experimental & Molecular Medicine·Yoon Seong Kim, Tong H Joh
Oct 31, 2006·Oncogene·M S HaydenS Ghosh
Nov 15, 2006·Archives of Neurology·Abimbola AkomolafeSudha Seshadri
Jun 6, 2007·The Journal of Clinical Investigation·Solomon S ShaftelM Kerry O'Banion
Sep 21, 2007·Journal of Neuropathology and Experimental Neurology·Robert E Mrak, W Sue T Griffin
Oct 2, 2007·Trends in Neurosciences·Jennifer Pocock, Helmut Kettenmann
Apr 9, 2008·European Journal of Pharmacology·Raoul P KloppenborgGeert Jan Biessels
Apr 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tristan BolmontMichael E Calhoun
Jul 17, 2008·Archives of Physiology and Biochemistry·Iria Nieto-VazquezMargarita Lorenzo
Aug 13, 2008·Cellular and Molecular Life Sciences : CMLS·J H Stockley, C O'Neill
Aug 15, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suzanne E HickmanJoseph El Khoury
Dec 24, 2008·Journal of Neuropathology and Experimental Neurology·Peter T NelsonWilliam R Markesbery
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Fernanda G De FeliceWilliam L Klein
Apr 24, 2009·Journal of Alzheimer's Disease : JAD·Ivica GranicUlrich L M Eisel
Oct 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paramita ChakrabartyPritam Das
Nov 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Virginie RheinAnne Eckert
Dec 10, 2009·Dementia and Geriatric Cognitive Disorders·Orestes Vicente ForlenzaAntonio L Teixeira
Jan 12, 2010·Journal of Alzheimer's Disease : JAD·M Paul Murphy, Harry LeVine
Feb 4, 2010·Alzheimer's Research & Therapy·Elina ZotovaDelphine Boche
Mar 23, 2010·Cell·Christopher K GlassFred H Gage
Mar 23, 2010·Nature Neuroscience·Martin FuhrmannJochen Herms
May 27, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Minoru KanekoNaoji Amano
Jun 22, 2010·Immunology·Sandra AmorPaul van der Valk
Jul 27, 2010·Advances in Pharmacology·Claire L Padgett, Paul A Slesinger
Aug 4, 2010·Current Alzheimer Research·K IqbalI Grundke-Iqbal
Aug 10, 2010·Biological Psychiatry·Walter SwardfagerNathan Herrmann
Nov 3, 2010·Nutrition·Stephen CunnaneStanley I Rapoport
Nov 4, 2010·Glia·Moonhee LeePatrick L McGeer
Nov 19, 2010·The Journal of Nutrition, Health & Aging·B JuraskovaJ Krejsek
Jan 25, 2011·Journal of the Neurological Sciences·Yonggang ZhangHong Fan
Feb 8, 2011·Biochimica Et Biophysica Acta·Jürgen SchellerStefan Rose-John
Mar 8, 2011·Current Molecular Medicine·P A McCombe, R D Henderson
Apr 5, 2011·Annual Review of Neuroscience·Richard J O'Brien, Philip C Wong
Jul 16, 2011·Dementia and Geriatric Cognitive Disorders·D ChengJ A Luchsinger
Sep 1, 2011·Cell and Tissue Research·Filippo CaraciAgata Copani
Oct 26, 2011·Brain Research Bulletin·Joshua A SmithNaren L Banik
Nov 24, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Linnea R Freeman, Ann-Charlotte E Granholm
Feb 4, 2012·The Journal of Biological Chemistry·Kohei YuyamaYasuyuki Igarashi
Mar 7, 2012·Neuroscience and Biobehavioral Reviews·Thamil Mani Sivanandam, Mahendra Kumar Thakur
Apr 11, 2012·Journal of Neuropathology and Experimental Neurology·Peter T NelsonThomas G Beach
May 9, 2012·TheScientificWorldJournal·Jose Miguel Rubio-Perez, Juana Maria Morillas-Ruiz
Jun 2, 2012·International Journal of Alzheimer's Disease·Robert E Mrak
Aug 23, 2012·Frontiers in Computational Neuroscience·Karim Le MeurEtienne Audinat
Oct 16, 2012·Neurobiology of Aging·Tiffany L SudduthDonna M Wilcock
Nov 16, 2012·The New England Journal of Medicine·Thorlakur JonssonKari Stefansson
Nov 16, 2012·The New England Journal of Medicine·Rita GuerreiroAlzheimer Genetic Analysis Group
Jan 9, 2013·Nature Reviews. Neurology·Chia-Chen LiuGuojun Bu
Jan 29, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ukpong B Eyo, Michael E Dailey
Jul 23, 2013·Frontiers in Aging Neuroscience·Joshua J BreunigTerrence Town
Aug 21, 2013·Clinical & Developmental Immunology·Gisa EllrichmannRalf A Linker
Aug 28, 2013·Journal of Neurovirology·Jayasri Das Sarma
Sep 5, 2013·Journal of Alzheimer's Disease : JAD·Nan HuLan Tan
Sep 21, 2013·Frontiers in Molecular Neuroscience·Robert I RichardsCatherine M Suter
Oct 29, 2013·Nature Neuroscience·Suzanne E HickmanJoseph El Khoury
Nov 2, 2013·The Journal of Clinical Investigation·Michail S LionakisPhilip M Murphy
Nov 5, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea PonzettaGiovanni Bernardini
Dec 18, 2013·Immunology·Sandra AmorJohannes M van Noort
Dec 20, 2013·Open Biology·Graham K Sheridan, Keith J Murphy
Dec 20, 2013·Drug Design, Development and Therapy·Laura GhezziDaniela Galimberti
Dec 21, 2013·Biochemical Pharmacology·Suzanne E Hickman, Joseph El Khoury
Feb 18, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sergio T FerreiraFernanda G De Felice
Mar 19, 2014·Nature Reviews. Neurology·V Hugh Perry, Clive Holmes
Mar 22, 2014·Neuroscience Bulletin·Evan DoreyWandong Zhang
Jun 5, 2014·Molecular Neurodegeneration·Jason D UlrichDavid M Holtzman
Jul 10, 2014·Journal of Neuroinflammation·Eduardo Rigon ZimmerPedro Rosa-Neto
Jan 1, 2013·Journal of Huntington's Disease·Edina SilajdžićMaria Björkqvist
Aug 26, 2014·Frontiers in Cellular Neuroscience·Cristina Limatola, Richard M Ransohoff
Sep 23, 2014·The Journal of Physiology·Bo-Eun YoonC Justin Lee
Nov 26, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alan I Faden, David J Loane
Dec 5, 2014·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Saeed Sadigh-EteghadJavad Mahmoudi
Dec 11, 2014·Acta Neuropathologica·Rebecca M NisbetJürgen Götz
Jan 27, 2015·Neuron·Marie-Victoire Guillot-SestierTerrence Town
Jan 30, 2015·Acta Neuropathologica·Claudia CantoniLaura Piccio
Mar 11, 2015·British Journal of Pharmacology·Ila P KarvePeter J Crack
Mar 17, 2015·Molecular and Cellular Neurosciences·Helen LingHenrik Zetterberg
Apr 10, 2015·The Journal of Biological Chemistry·Christian Madry, David Attwell
Apr 18, 2015·Frontiers in Neuroanatomy·María-Trinidad HerreroSheela Vyas
Apr 18, 2015·Molecular Neurodegeneration·Sheng Chih JinNilüfer Ertekin-Taner
Apr 22, 2015·The Journal of Clinical Investigation·Pietro Luigi PolianiMarco Colonna
Apr 24, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julie C SavageGary E Landreth
Apr 24, 2015·Alzheimer's Research & Therapy·Diego Gomez-Nicola, Delphine Boche
May 24, 2015·Trends in Immunology·Andrea Crotti, Christopher K Glass
Sep 29, 2015·Nature Neuroscience·Gail ChanPhilip L De Jager
Oct 16, 2015·Translational Neurodegeneration·Qinqin WangJiawei Zhou
Jan 28, 2016·Neuroscience and Biobehavioral Reviews·Chelcie F Heaney, Jefferson Kinney
Feb 13, 2016·Cell·Bart De Strooper, Eric Karran
Feb 24, 2016·Current Alzheimer Research·Jelena DjordjevicBenedict C Albensi
Mar 5, 2016·Molecular Medicine Reports·Wei-Wei ChenWen-Juan Huang
Mar 5, 2016·Frontiers in Aging Neuroscience·Yanfang LiHui Zheng
Mar 27, 2016·Biochimica Et Biophysica Acta·Michelle RothaugStefan Rose-John
Apr 20, 2016·The Journal of Experimental Medicine·Yaming WangMarco Colonna
Sep 21, 2016·Alzheimer's Research & Therapy·Jeffrey CummingsPhilip Scheltens
Dec 2, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jose Henrique LedoSergio T Ferreira
Jan 20, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Taylor R JayGary E Landreth
Apr 8, 2017·Acta Neuropathologica·Tong GuoDiane P Hanger
May 19, 2017·Journal of Neural Transmission·Julien LagardeMichel Bottlaender
May 24, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Dunja Knezevic, Romina Mizrahi
Jun 6, 2017·Journal of Central Nervous System Disease·Rudy ChangRachita K Sumbria
Jun 14, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luan Pereira DinizFlávia Carvalho Alcantara Gomes
Jul 7, 2017·Experimental Neurobiology·Yoo Sung Kim, Bo-Eun Yoon
Aug 13, 2017·Cell·Tyler K UllandMarco Colonna
Oct 27, 2017·Proceedings of the National Academy of Sciences of the United States of America·Cheryl E G LeynsDavid M Holtzman
Dec 20, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Wei LiAndrew J Saykin

Citations

Aug 2, 2019·Current Alzheimer Research·Xiao-Ying SunRui-Tian Liu
Nov 14, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Eugenia Trushina
Nov 14, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Daniel K BurnsAnn M Saunders
Jan 25, 2020·International Journal of Molecular Sciences·Pi-Shan SungKuen-Jer Tsai
Jan 29, 2020·Journal of Biomedical Science·Yoshihito HayashiKuen-Jer Tsai
Sep 26, 2019·Communications Biology·Sayan GhoshDebasish Sinha
Oct 2, 2019·Journal of Dual Diagnosis·Hye Bin YooFrancesca M Filbey
May 24, 2019·The British Journal of Ophthalmology·Jacoba Alida van de KreekePieter Jelle Visser
Aug 14, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chanung Wang, David M Holtzman
Feb 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Masaru TanakaLászló Vécsei
Nov 22, 2019·The FEBS Journal·Amanda B ChaiIngrid C Gelissen
Mar 14, 2020·Clinical Science·Miroslava KacířováLenka Maletínská
Feb 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Tanusree SenNilkantha Sen
Mar 7, 2020·Biomolecules·Nehal M ElsherbinyAmany Tawfik
Mar 15, 2020·Psychiatry and Clinical Neurosciences·Sun-Wung HsiehYuan-Han Yang
May 1, 2020·The Cochrane Database of Systematic Reviews·Fionnuala JordanDeclan Devane
Nov 7, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joan P GravesDarryl C Zeldin
Feb 12, 2020·Reviews in the Neurosciences·Valentin DichevVictoria Sarafian
Jan 17, 2020·Current Pharmaceutical Design·Patricia Regina ManzineMarcia Regina Cominetti
Mar 8, 2020·Antioxidants & Redox Signaling·Carlo CervellatiGiuseppe Valacchi
Feb 1, 2020·Current Neuropharmacology·Sara MerloMaria Angela Sortino
Jun 13, 2020·The European Journal of Neuroscience·Fanny JaudonLorenzo A Cingolani
Aug 15, 2019·Journal of Neuroinflammation·Giulia Di BenedettoGiuseppina Cantarella
Aug 13, 2020·Journal of Clinical and Experimental Neuropsychology·Ruhee A PatelMadeleine E Hackney
Jun 12, 2019·Connective Tissue Research·Gabrielle FrameChristine M Dengler-Crish
Aug 23, 2020·Journal of Cellular and Molecular Medicine·Shiqi GaoAnwen Shao
Jun 27, 2020·Immunological Reviews·Hannah E Ennerfelt, John R Lukens
Aug 30, 2020·Sleep·Andrée-Ann BarilJayandra J Himali
Sep 26, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Xu-Qiao ChenWilliam C Mobley
Sep 13, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Audrey LowJohn T O'Brien
Mar 27, 2020·The Journal of Experimental Medicine·Caterina P ProfaciRichard Daneman
Jan 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fanhui KongKun Wei
Jul 21, 2019·Cells·Onanong Mee-IntaYu-Min Kuo
Apr 21, 2020·Metabolomics : Official Journal of the Metabolomic Society·Jeremy P KoelmelJohn A Bowden
Aug 28, 2020·International Journal of Molecular Sciences·Filip JovanovicNebojsa Nick Knezevic
Sep 14, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Emily EruysalMakoto Ishii
Oct 23, 2019·Frontiers in Aging Neuroscience·Ena ŠpanićGoran Šimić
Dec 24, 2019·Frontiers in Cell and Developmental Biology·Yoo Jin JungNigel H Greig
Jul 16, 2020·International Journal of Molecular Sciences·Umar H IqbalGiulio M Pasinetti
Jul 29, 2020·Frontiers in Physiology·Daniela LiccardoAlessandro Cannavo
Aug 7, 2019·Aging Cell·Paola SebastianiThomas T Perls
Oct 2, 2019·Neural Regeneration Research·Bettina M Foidl, Christian Humpel
Jan 11, 2020·Frontiers in Aging Neuroscience·Georgia R FrostYue-Ming Li
Jul 3, 2019·International Journal of Molecular Sciences·Yasuhisa AnoHiroyuki Nakayama
Nov 15, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Romina VuonoJanelle Drouin-Ouellet
Jul 18, 2020·International Journal of Molecular Sciences·Alex Cleber Improta-CariaBruno Solano de Freitas Souza
Jul 24, 2020·Annals of the New York Academy of Sciences·Mazel MihardjaLee Wei Lim
Jul 30, 2020·Molecular Neurobiology·Ajmal AhmadMohammad Moshahid Khan
Aug 14, 2020·EMBO Molecular Medicine·Michael EwersNicolai Franzmeier
Apr 23, 2020·Frontiers in Aging Neuroscience·Maiko T UemuraJohn Q Trojanowski
May 7, 2020·International Journal of Molecular Sciences·Gabriela Lopes MartinsHelton José Reis
May 16, 2020·Oxidative Medicine and Cellular Longevity·Alyne Mendonça Marques TonElisardo Corral Vasquez
Sep 26, 2020·Frontiers in Aging Neuroscience·Ishan Agrawal, Sushmita Jha
Aug 30, 2020·Journal of Personalized Medicine·Paola BossùGianfranco Spalletta
Oct 6, 2020·Journal of Alzheimer's Disease : JAD·Paula Duarte-GutermanAlzheimer’s Disease Neuroimaging Initiative
Aug 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rim WehbeZiad Fajloun
Mar 15, 2020·Antioxidants·Wojciech Grodzicki, Katarzyna Dziendzikowska
Apr 19, 2020·Expert Review of Neurotherapeutics·Eleazar Ramírez HernándezI Daniel Limón Pérez de León
May 8, 2020·International Journal of Molecular Sciences·Matteo BordoniCristina Cereda
Apr 8, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Mark MapstoneAlzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators
Feb 14, 2020·International Journal of Molecular Sciences·Ariel AngelDaniel Offen
Jul 28, 2020·Stem Cell Reviews and Reports·Samantha E Spellicy, Steven L Stice
Jun 24, 2020·Scientific Reports·Stefan M IvanovIrini A Doytchinova
Aug 6, 2020·Journal of Personalized Medicine·Sean X NaughtonGiulio M Pasinetti
Jun 9, 2020·Frontiers in Neuroscience·Michele DibattistaJohannes Reisert
Jul 3, 2019·International Journal of Molecular Sciences·Eryn L WerryMichael Kassiou
Sep 12, 2019·Frontiers in Pharmacology·Knut BiberThomas Möller
Feb 13, 2020·International Journal of Molecular Sciences·Fabiana NovellinoGiuseppe Donato
May 5, 2020·Frontiers in Aging Neuroscience·Bruno Dutra ArboMariana Appel Hort
Apr 8, 2020·Frontiers in Cellular Neuroscience·Christos Galanis, Andreas Vlachos
Oct 8, 2020·Médecine sciences : M/S·Claire AndréGéraldine Rauchs
Aug 6, 2020·International Journal of Molecular Sciences·Jin-Seok LeeChang-Gue Son
Sep 22, 2020·Biomaterials Science·Chengyuan QianXiaohui Wang
Oct 8, 2020·International Journal of Molecular Sciences·Ajay AshokRithvik Ayyagari
Oct 20, 2020·Frontiers in Molecular Neuroscience·Maria MerezhkoHenri J Huttunen
Oct 20, 2020·Acta Ophthalmologica·Jacoba A van de KreekeFrank D Verbraak
Sep 15, 2020·Journal of Alzheimer's Disease : JAD·Roberto SantangeloLetizia Leocani
Nov 12, 2020·Molecular Psychiatry·Sumin YangJae-Yeol Joo
Oct 30, 2020·Journal of Neurotrauma·Steven T DeKoskyRonald L Hayes
Oct 14, 2020·Neurology·Francis N SaridinChristopher L H Chen
Nov 28, 2020·Brain : a Journal of Neurology·Zhi RuanTsuneya Ikezu
Feb 4, 2019·Alzheimer's Research & Therapy·Lorenza MagnoPaul J Whiting
Oct 21, 2020·Biomedicines·Adrian Florian BălașaAlexandru Mihai Grumezescu
Dec 4, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Brett M FryeCarol A Shively
Dec 14, 2019·Alzheimer's Research & Therapy·Daria BortolottiRoberta Rizzo
May 20, 2019·Journal of Alzheimer's Disease : JAD·Hugo McGurranNicholas T Bott
May 17, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Kacper ToczylowskiArtur Sulik
Dec 11, 2020·The American Journal of Chinese Medicine·Yong Ho KuHyun Lee
Jul 14, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Gang DengChanghong Wang
Dec 7, 2020·Journal of Pharmaceutical and Biomedical Analysis·Marcela KonjevodDavid Rojo
Jul 8, 2019·Brain, Behavior, and Immunity·Rachel Pei-Hsuan WangRaymond Chuen-Chung Chang
Dec 16, 2020·Molecular and Cellular Endocrinology·Lucas ZangerolamoHelena C L Barbosa
Nov 22, 2020·Journal of Neurochemistry·Christine N Metz, Valentin A Pavlov
Aug 14, 2019·Trends in Pharmacological Sciences·Miao-Kun Sun, Daniel L Alkon
Sep 1, 2019·Journal of Neuroimmunology·Carolina A MagalhãesKarina B Gomes
Dec 29, 2020·Journal of Neurochemistry·Hannah L BestStephanie M Hughes
Jan 20, 2021·CNS Neuroscience & Therapeutics·Justin ChoCesar V Borlongan
Jan 22, 2021·Annals of Clinical and Translational Neurology·Karthick NatarajanCaroline Graff
Jan 23, 2021·Scientific Reports·Nicholas C CullenNiklas Mattsson-Carlgren
Jan 27, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luis David Arango-De la PavaGabriela Trejo-Tapia
Dec 17, 2019·Drug and Alcohol Dependence·Hasti HadizadehHamid Reza Ahmadkhaniha
Oct 15, 2019·Journal of Alzheimer's Disease : JAD·Nathan M D'CunhaNenad Naumovski
Feb 11, 2021·The American Journal of Clinical Nutrition·Annick P M van SoestLisette C P G M de Groot
Feb 11, 2021·Journal of Personalized Medicine·Keren NitzanRavid Doron
Feb 14, 2021·Journal of Alzheimer's Disease : JAD·Timothy M ShoupRudolph E Tanzi
Jan 16, 2021·Scientific Reports·Shinwoo KangKeun-A Chang
Feb 9, 2021·Frontiers in Cellular Neuroscience·Sana ChintamenSteven G Kernie
Nov 3, 2020·Frontiers in Aging Neuroscience·Yangdi PengAlzheimer’s Disease Neuroimaging Initiative
Nov 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Amanda K EngstromDavid J Katz
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yew Rong KongKooi Yeong Khaw
Feb 12, 2021·Bioorganic Chemistry·Pritam ThapaMukut Sharma
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Zongxin LingShaochang Wu
Dec 19, 2020·Scientific Reports·Snow BachDaniela Tropea
Dec 20, 2020·International Journal of Molecular Sciences·You Jung KangHansang Cho
Dec 22, 2020·Frontiers in Molecular Neuroscience·Yoshiyuki Soeda, Akihiko Takashima
Jan 16, 2021·Biosensors·Jose Marrugo-RamírezJosep Samitier
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·David A Loeffler
Feb 2, 2021·Frontiers in Neuroscience·Henriette Haukedal, Kristine K Freude
Nov 10, 2020·Journal of Alzheimer's Disease : JAD·Christopher B PopleNir Lipsman
Nov 20, 2020·Pharmaceuticals·William M Pardridge
Dec 22, 2020·Journal of Medicinal Chemistry·Angela De SimoneAndrea Milelli
Jan 19, 2021·European Journal of Pharmacology·Ranjit Singh, Ranju Bansal
Nov 3, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jinhui ShiHongmei Zhang
Dec 15, 2020·International Journal of Epidemiology·Chris Ho Ching Yeung, C Mary Schooling
Jan 17, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael Fossel
Jan 14, 2020·Journal of Alzheimer's Disease : JAD·Yasuhisa AnoHiroyuki Nakayama
Feb 12, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Daiene de Morais FabrícioBreno S Diniz
Feb 22, 2020·Archives of Physical Medicine and Rehabilitation·I-Ting LiuYuan-Yang Cheng
Feb 25, 2020·Experimental Neurology·Eric E Abrahamson, Milos D Ikonomovic
Mar 4, 2021·International Journal of Molecular Sciences·Gaia PiccioniRobert Nisticò
Mar 19, 2020·Metabolic Brain Disease·Shamseddin AhmadiSteven Bradburn
Apr 4, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Igor Henrique R PaivaChristina Alves Peixoto
Apr 16, 2020·Free Radical Biology & Medicine·Ming-Hung WengGow-Chin Yen
Feb 23, 2021·Colloids and Surfaces. B, Biointerfaces·Matheus Scarpatto RodriguesJade de Oliveira
Jan 12, 2020·Communications Biology·Sayan GhoshDebasish Sinha
Mar 6, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Floris ChabrunPascal Reynier
Feb 27, 2021·Stem Cell Reports·Kelsey R BabcockAshley E Webb
Feb 23, 2021·ACS Pharmacology & Translational Science·Pragya Prasanna, Arun Upadhyay
Mar 5, 2021·Reviews in the Neurosciences·Harish IyerArvind Kumar
Mar 4, 2021·Biomolecules·Talya ShachamGerardo Z Lederkremer
Mar 13, 2021·Ageing Research Reviews·Milan StoiljkovicMihály Hajós
Mar 16, 2021·Journal of Alzheimer's Disease : JAD·Irundika H K Dias, Helen R Griffiths
Jul 28, 2020·JAD Reports·Benjamin SinyorChristopher Ochner
Mar 16, 2021·Frontiers in Cell and Developmental Biology·Tiffany G RoachDaniel G S Capelluto
Mar 18, 2021·Ageing Research Reviews·Tongmei ZhangYouming Lu
Mar 17, 2021·Cell Adhesion & Migration·Smita Eknath Desale, Subashchandrabose Chinnathambi
Jun 17, 2020·Journal of Alzheimer's Disease : JAD·Bernadeth Lyn C PiamonteVeeda Michelle M Anlacan
Mar 19, 2020·Cell Reports·Lea L FrikerMichael T Heneka
Sep 18, 2020·Molecular Genetics and Metabolism Reports·Randall C MazzarinoGuido N Vacano
Sep 7, 2020·Mechanisms of Ageing and Development·Ioanna Daskalaki, Nektarios Tavernarakis
Apr 3, 2021·Antioxidants·Eduardo Felipe Alves Fernandes, Dennis Özcelik
Apr 4, 2021·International Journal of Molecular Sciences·Sean T RyanJiao Jiao Li
Nov 25, 2020·Neurobiology of Aging·Arnold SalazarJefferson Kinney
May 1, 2021·Molecular Neurodegeneration·Mabel SetoTimothy J Hohman
Apr 19, 2021·Frontiers in Neuroscience·Punam Rawal, Liqin Zhao
Dec 11, 2020·Brain, Behavior, and Immunity·Jessica Z K CaldwellGeorge M Slavich
May 4, 2021·Journal of Alzheimer's Disease : JAD·Taylor J KrivanekKirk R Daffner
Mar 27, 2021·Neuropathology and Applied Neurobiology·Katie A BretlandChristine M Dengler-Crish
May 10, 2021·Frontiers in Cell and Developmental Biology·Longxiu YangChongdong Jian
May 9, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alexandru SavaLenuţa Profire
Nov 11, 2019·Neuroscience and Biobehavioral Reviews·Paula DesplatsMartin G Frasch
Mar 11, 2021·American Journal of Physiology. Cell Physiology·Leena P Bharath, Barbara S Nikolajczyk
Nov 3, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Hong JiangTania Rundek
Jun 3, 2020·Current Neuropharmacology·Sahil KhanMaushmi S Kumar
Jan 22, 2021·Physiological Reviews·Sandro Sorbi, Camilla Ferrari
Sep 6, 2020·Progress in Retinal and Eye Research·Veer B GuptaVivek Gupta
Jun 3, 2021·Biology·Elmira I YakupovaAlexander G Bobylev
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Charinya KhamphukdeeAnake Kijjoa
Jun 3, 2021·Neuropsychiatric Disease and Treatment·Pan FuAlzheimer’s Disease Neuroimaging Initiative
May 23, 2021·The International Journal of Biochemistry & Cell Biology·Jeremy Kean Yi YapElaine Wan Ling Chan
Jun 10, 2021·Acta Pharmacologica Sinica·Delphine JiHong-Shuo Sun

Methods Mentioned

BETA
flow cytometry
transgenic

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