Inflammation, Cognition, and White Matter in Older Adults: An Examination by Race.

Frontiers in Aging Neuroscience
Elizabeth A BootsMelissa Lamar

Abstract

Non-Latino Black adults have greater risk for Alzheimer's dementia compared to non-Latino White adults, possibly due to factors disproportionally affecting Black adults including cardiovascular disease (CVD). Chronic peripheral inflammation is implicated in both Alzheimer's dementia and CVD and is known to impact cognition and cerebral white matter, yet little work has examined these associations by race. This study examined associations between inflammation, cognition, and cerebral white matter generally, and by race. Eighty-six non-demented older Black and White participants (age = 69.03; 50% female; 45% Black participants) underwent fasting venipuncture, cognitive testing, and MRI. Serum was assayed for interleukin-6 (IL-6), C-reactive protein (CRP), and interleukin 1-beta. Cognitive domains included memory, executive function, and attention/information processing. MRI measures included white matter hyperintensity volumes (WMH) and quantification of white matter integrity in areas outside WMHs via DTI-derived fractional anisotropy (FA) and mean diffusivity, as well as multi-component relaxometry derived myelin water fraction (MWF). Black and White participants did not differ on age, sex, or CVD risk. Separate linear regressi...Continue Reading

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Methods Mentioned

BETA
blood draw
ELISA
blood draws

Software Mentioned

FIESTA
Brain Extraction Tool
FreeSurfer
Advanced Tools
SPSS
mcDESPOT
FMRIB

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