Inflammation, demyelination, and degeneration - recent insights from MS pathology

Biochimica Et Biophysica Acta
Christine StadelmannWolfgang Brück

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system which responds to anti-inflammatory treatments in the early disease phase. However, the pathogenesis of the progressive disease phase is less well understood, and inflammatory as well as neurodegenerative mechanisms of tissue damage are currently being discussed. This review summarizes current knowledge on the interrelation between inflammation, demyelination, and neurodegeneration derived from the study of human autopsy and biopsy brain tissue and experimental models of MS.

References

Nov 1, 1995·Annals of Neurology·W BrückH Lassmann
Dec 1, 1994·Brain : a Journal of Neurology·K OzawaH Lassmann
Feb 1, 1993·Annals of Neurology·J W PrineasE S Cho
Mar 1, 1997·Brain : a Journal of Neurology·B FergusonV H Perry
May 26, 1998·Multiple Sclerosis : Clinical and Laboratory Research·I MewsW Brück
Dec 3, 1999·Brain : a Journal of Neurology·C LucchinettiH Lassmann
Jan 29, 2000·Brain : a Journal of Neurology·G LovasS Komoly
May 29, 2000·Brain : a Journal of Neurology·A BitschW Brück
Nov 15, 2001·Annals of Neurology·J W PrineasB P Morgan
Feb 15, 2002·Brain : a Journal of Neurology·Guus Wolswijk
Jun 22, 2002·Brain : a Journal of Neurology·Claudia F LucchinettiHans Lassmann
Sep 24, 2002·Brain : a Journal of Neurology·Tanja KuhlmannWolfgang Brück
Oct 29, 2002·Annals of Neurology·Alberto CifelliPaul M Matthews
Jan 31, 2003·Annals of Neurology·Raju KapoorKenneth J Smith
Mar 5, 2003·Brain : a Journal of Neurology·Christian ConfavreuxPatrice Adeleine
Jul 10, 2003·Lancet Neurology·Kenneth J Smith, Hans Lassmann
Mar 30, 2004·Brain : a Journal of Neurology·G C DeLucaM M Esiri
Mar 30, 2004·Annals of Neurology·Michael H Barnett, John W Prineas
Oct 20, 2004·The Journal of Experimental Medicine·Martin KerschensteinerMartin E Schwab
Oct 21, 2004·The Journal of Biological Chemistry·Anja SchneiderMikael Simons
May 17, 2005·Journal of the Neurological Sciences·Alexandra Kutzelnigg, Hans Lassmann
Aug 10, 2005·The Journal of Experimental Medicine·Vanda A LennonShannon R Hinson
Sep 10, 2005·Brain : a Journal of Neurology·Ian M PomeroyMargaret M Esiri
Oct 19, 2005·Brain : a Journal of Neurology·Alexandra KutzelniggHans Lassmann
Nov 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·S J PittockC F Lucchinetti
Dec 2, 2005·Journal of Neuropathology and Experimental Neurology·Marco VercellinoPaola Cavalla
Mar 3, 2006·The New England Journal of Medicine·Elliot M FrohmanCedric S Raine
Aug 4, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chi Wang IpRudolf Martini
Aug 22, 2006·Brain : a Journal of Neurology·Peter PatrikiosHans Lassmann
Jan 24, 2007·Nature Medicine·Kevin C O'ConnorKai W Wucherpfennig
Feb 7, 2007·Brain : a Journal of Neurology·Shanu F RoemerClaudia F Lucchinetti
Mar 29, 2007·Brain Pathology·Monika AlbertChristine Stadelmann
Apr 7, 2007·Journal of Neuropathology and Experimental Neurology·Ruth HuizingaSandra Amor

❮ Previous
Next ❯

Citations

Aug 13, 2011·Cell Death and Differentiation·J L VeneroB Joseph
Jun 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Monan Angela ZhangShannon E Dunn
Dec 26, 2012·Brain : a Journal of Neurology·Thomas SkripuletzMartin Stangel
Mar 23, 2012·BMC Neuroscience·André Michael MüllerSaud Ahmed Sadiq
Oct 13, 2012·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Ryoichi HayakawaHidenori Ichijo
Nov 1, 2013·Clinical & Developmental Immunology·Genaro G OrtizErandis D Torres-Sánchez
Jun 1, 2011·FEBS Letters·Bente Finsen, Trevor Owens
Dec 19, 2015·Pharmacogenetics and Genomics·Ekaterina TsarevaOlga Favorova
Jan 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bart J CrielaardGert Storm
Sep 20, 2011·Pharmacology & Therapeutics·Andrew J HillGary J Stephens
Sep 13, 2011·Journal of Neuroimmunology·Subramaniam Sriram
Mar 29, 2011·Neurologic Clinics·Gavin Giovannoni
Mar 26, 2016·Frontiers in Immunology·Helena RadbruchRaluca Niesner
Jan 23, 2013·Neuropathology and Applied Neurobiology·G C DeLucaG C Ebers
Nov 1, 2012·Proteomics. Clinical Applications·Laura F DagleyAnthony W Purcell
May 7, 2014·Journal of Neuroscience Research·Dongliang ZhuXiaohong Chen
Dec 20, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A ShiraniH Tremlett
Apr 5, 2013·Neuropathology and Applied Neurobiology·Corinne BranaTimothy J Seabrook
Jul 23, 2015·Annals of the New York Academy of Sciences·Marloes PrinsAnne-Marie van Dam
Sep 14, 2012·Neurological Research·Yuval KarmonBianca Weinstock-Guttman
Apr 14, 2016·Experimental Neurology·Ian D Duncan, Abigail B Radcliff
Jul 10, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sarah K OrrRichard P Bazinet
Apr 22, 2015·Multiple Sclerosis and Related Disorders·Fred D LublinShibeshih Belachew

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.