Inflammation, edema and poor outcome are associated with hyperthermia in hypertensive intracerebral hemorrhages

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
R Iglesias-ReyJosé Castillo

Abstract

The deleterious effect of hyperthermia on intracerebral hemorrhage (ICH) has been studied. However, the results are not conclusive and new studies are needed to elucidate clinical factors that influence the poor outcome. The aim of this study was to identify the clinical factors (including ICH etiology) that influence the poor outcome associated with hyperthermia and ICH. We also tried to identify potential mechanisms involved in hyperthermia during ICH. We conducted a retrospective study enrolling patients with non-traumatic ICH from a prospective registry. We used logistic regression models to analyze the influence of hyperthermia in relation to different inflammatory and endothelial dysfunction markers, hematoma growth and edema volume in hypertensive and non-hypertensive patients with ICH. We included 887 patients with ICH (433 hypertensive, 50 amyloid, 117 by anticoagulants and 287 with other causes). Patients with hypertensive ICH showed the highest body temperature (37.5 ± 0.8°C) as well as the maximum increase in temperature (0.9 ± 0.1°C) within the first 24 h. Patients with ICH of hypertensive etiologic origin, who presented hyperthermia, showed a 5.3-fold higher risk of a poor outcome at 3 months. We found a positive ...Continue Reading

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Citations

Mar 30, 2020·Neurology·Pablo HervellaRamón Iglesias-Rey
Jun 30, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A Honig, R R Leker
Dec 7, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·B VolbersH B Huttner
Mar 25, 2021·Stroke and Vascular Neurology·Andrés da Silva-CandalPablo Hervella
Oct 26, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Gui-Jun ZhangXiao-Yu Wang

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