Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Eric J DuellElizabeth A Holly

Abstract

Adenocarcinoma of the exocrine pancreas is the fourth leading cause of cancer-related death in men and women in the U.S. Cytokines and other proinflammatory mediators have been implicated in inflammatory pancreatic diseases including pancreatitis and cancer. We analyzed cytokine gene polymorphisms as risk factors for pancreatic cancer using questionnaire data obtained by in-person interviews and germ line DNA collected in a population-based case-control study of pancreatic cancer (532 cases and 1,701 controls) conducted in the San Francisco Bay Area. We used mass spectrometry and gel-based methods to genotype 308 cases and 964 population-based controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression analysis and included adjustment for age, sex, and smoking. We assessed potential interactions between these polymorphisms, proinflammatory conditions (e.g., pancreatitis, ulcer, and obesity), and smoking as risk factors for pancreatic cancer. There was no overall association between pancreatic cancer risk and tumor necrosis factor-alpha (TNF-A -308G/A), regulated upon activation, normally T cell-expressed, and presumably secreted (RANTES -403G/A), and CC chemokine receptor 5 (CCR5-Delta3...Continue Reading

References

Jul 1, 1986·American Journal of Epidemiology·W Willett, M J Stampfer
May 20, 1993·The New England Journal of Medicine·A B LowenfelsL Domellöf
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·A G WilsonG W Duff
May 1, 1997·Nature Genetics·J J MartinsonJ B Clegg
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·H LiuT Shioda
Sep 1, 1999·Clinical and Experimental Immunology·M D BarberJ A Ross
Dec 20, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·A H HajeerW E Ollier
Jun 3, 2000·Annual Review of Immunology·D Rossi, A Zlotnik
Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y A DeClerck
Sep 7, 2001·Cytokine & Growth Factor Reviews·R Horuk
Nov 6, 2001·Annals of Internal Medicine·J P IoannidisUNKNOWN International Meta-Analysis of HIV Host Genetics
Mar 20, 2002·Cytokine & Growth Factor Reviews·Fran Balkwill
Mar 20, 2002·Cytokine & Growth Factor Reviews·Alain P Vicari, Christophe Caux
Aug 26, 2003·American Journal of Epidemiology·Elizabeth A HollyPaige M Bracci
Sep 10, 2003·Journal of Clinical Gastroenterology·Nakechand PooranSimmy Bank
Oct 4, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Kazuhito TasakiTadao Bamba
Jan 7, 2004·Nature Reviews. Cancer·Glenn Dranoff
May 29, 2004·Annals of Surgery·Buckminster FarrowB Mark Evers
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

❮ Previous
Next ❯

Citations

Mar 12, 2009·Cancer Causes & Control : CCC·June M ChanElizabeth A Holly
Sep 18, 2009·Cancer Causes & Control : CCC·Paige M BracciElizabeth A Holly
Jun 20, 2008·Obesity Surgery·Andrew A Gumbs
Dec 23, 2008·BMC Cancer·Pablo Sáenz-LópezFrancisco Ruiz-Cabello
Mar 22, 2014·PloS One·Barbara A HocevarE Gabriela Chiorean
Jan 11, 2014·World Journal of Gastroenterology : WJG·Xu-Feng GuoWei-Guo Dong
Mar 1, 2008·Journal of Gastroenterology·Jyh-Ming LiouMing-Shiang Wu
Feb 5, 2010·Cellular and Molecular Life Sciences : CMLS·J SandovalG López-Rodas
Aug 21, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Kee Hwan KwonYoung Gyu Eun
Dec 30, 2009·Leukemia & Lymphoma·Paige M BracciJohn K Wiencke
Feb 22, 2013·Expert Opinion on Therapeutic Targets·Kathleen M HertzerO Joe Hines
Oct 13, 2009·Gastroenterology·Ying BaoDominique S Michaud
Apr 9, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·R L MilneN Malats
Jan 30, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Andrew A GumbsJohn Chabot
Aug 19, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jonas F LudvigssonAnders Ekbom
Sep 10, 2014·Journal of Receptor and Signal Transduction Research·Young Ho Lee, Gwan Gyu Song
Jan 26, 2007·Pediatric Blood & Cancer·Martin C Mahoney
Feb 26, 2008·Journal of Surgical Oncology·Hidekazu SugasawaHidetaka Mochizuki
Apr 15, 2008·Scandinavian Journal of Immunology·A SrivastavaB Mittal
Mar 3, 2009·Annals of the New York Academy of Sciences·Letizia ScolaDomenico Lio
Dec 14, 2011·Molecular Carcinogenesis·Sara H Olson
Jul 28, 2011·Scandinavian Journal of Immunology·T Qidwai, F Khan
Jul 31, 2009·International Journal of Cancer. Journal International Du Cancer·Eric J DuellPaige M Bracci
Jul 8, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Gui-Xian TongDe-Bin Wang
Apr 2, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Houqun YingXueren Gao
Apr 17, 2010·Mediators of Inflammation·Gül OzhanBuket Alpertunga
Jun 6, 2016·Immunology Letters·Tabish Qidwai
May 14, 2016·PloS One·Yandiswa Yolanda YakoMartin Brand
Mar 16, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Pierre Nahon, Jean-Charles Nault
Aug 31, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jyotirmoy GhoshNarayan G Avadhani
Nov 10, 2018·International Journal of Cancer. Journal International Du Cancer·Mitsukuni SuenagaHeinz-Josef Lenz
Aug 2, 2017·The American Journal of Gastroenterology·Jakob KirkegårdDeirdre Cronin-Fenton
Feb 8, 2008·The Biochemical Journal·Georgina L Hold, Emad M El-Omar
May 19, 2018·International Journal of Molecular Sciences·Donatella Aldinucci, Naike Casagrande

❮ Previous
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