Inflammation, heat shock proteins, and type 2 diabetes.

Cell Stress & Chaperones
Philip L Hooper, Paul L Hooper

Abstract

We propose that type 2 diabetes results from a vicious cycle of metabolically induced inflammation, impaired insulin responsiveness, and subsequent loss of homeostatic signaling. A crucial and previously under-recognized event contributing to this loss of homeostasis is a reduction in heat shock proteins (HSPs, or stress proteins). The central causal pathways of this cycle are the following: (a) obesity-driven inflammation promotes insulin resistance; (b) impaired insulin signaling in turn reduces the expression of HSPs, leaving tissues vulnerable to damage and allowing the accumulation of harmful proteins aggregates; and (c) resulting damage to the pancreatic beta-cell leads to further losses in insulin signaling, while a decline in anti-inflammatory HSPs allows inflammation to expand unhindered. Obesity and sedentary lifestyle perpetuate this cycle, while dieting and exercise forestall it by raising HSPs, reducing inflammation, and improving insulin signaling. Because HSP expression carries substantial metabolic costs, it is likely that an evolutionary history of high activity levels and resource scarcity selected for more conservative HSP expression than is appropriate for our current environment of caloric abundance.

References

Jul 18, 1997·The Journal of Biological Chemistry·V L GabaiM Y Sherman
Feb 2, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Aigang LuFrank R Sharp
Apr 13, 2004·Journal of Applied Physiology·Mustafa AtalayChandan K Sen
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Jul 28, 2007·Annals of the New York Academy of Sciences·Ian R Brown
Jan 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jason ChungMark A Febbraio
Feb 22, 2008·Current Pharmaceutical Design·M L Ferrándiz, I Devesa
Apr 24, 2008·Molecular Medicine·James P Stice, Anne A Knowlton

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Citations

May 25, 2010·Cell Stress & Chaperones·Manouchehr NakhjavaniTiago F Outeiro
Feb 11, 2012·Cell Stress & Chaperones·Zsuzsanna Literáti-NagyLászló Vígh
Sep 8, 2012·Genome Research·Alexandra E CharosMichael Snyder
Oct 30, 2013·Disease Markers·Fadia Mahmoud, Ebaa Al-Ozairi
Mar 2, 2012·Journal of Nutrigenetics and Nutrigenomics·Isabel Bondia-PonsJ Alfredo Martínez
Sep 7, 2012·Pathobiology of Aging & Age Related Diseases·Michal M Masternak, Andrzej Bartke
May 11, 2012·Future Medicinal Chemistry·Z NahlehZ Nahle
Jan 7, 2014·Metabolic Syndrome and Related Disorders·Botond Literáti-NagyZoltán Szilvássy
Feb 14, 2014·Cell Stress & Chaperones·Philip L HooperLaszlo Vigh
May 13, 2014·Diabetologia·Stéphane Jaisson, Philippe Gillery
Jan 5, 2012·Cell Stress & Chaperones·Josianne Rodrigues-KrauseGerard Colleran
May 4, 2013·Pathology Oncology Research : POR·Zsuzsanna Literati-NagyZoltán Szilvássy
Nov 5, 2016·Annals of Human Biology·Maryam Mardan-NikMajid Ghayour-Mobarhan
Dec 24, 2015·Current Hypertension Reports·Marisa Nile MolinaWalter Manucha
Mar 19, 2015·Experimental Neurology·HaeJee YoonMunmun Chattopadhyay
Sep 1, 2015·Journal of Physiology and Biochemistry·Baoheng XingXiaohua Wu
Dec 17, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A L HevenerUNKNOWN Stock Conference Working Group
Mar 14, 2014·Nutritional Neuroscience·Eka FujimotoKazuto Sato
May 23, 2014·Diabetes & Metabolism Journal·Tatsuya KondoEiichi Araki
Jun 11, 2016·Cell Stress & Chaperones·Philip L HooperLászló Vígh
Dec 8, 2015·Anemia·Jéssica BarbieriMatias Nunes Frizzo
Aug 23, 2016·Canadian Journal of Diabetes·Marzie Zilaee, Saeed Shirali
Apr 10, 2016·The Journal of Physiology·John M LawlerJeffrey M Hord
Mar 25, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Attila CzompaIstvan Lekli
Jul 25, 2019·Food & Function·Renata Celi Lopes ToledoJosé Humberto de Queiroz
Nov 6, 2014·American Journal of Physiology. Endocrinology and Metabolism·Abdelkrim KhadirMohammed Dehbi
Sep 26, 2017·Temperature : Multidisciplinary Biomedical Journal·S H FaulknerC A Leicht

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