Inflammation in Achromobacter xylosoxidans infected cystic fibrosis patients

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
C R HansenNiels Høiby

Abstract

Achromobacter xylosoxidans infection may cause conspicuous chronic pulmonary inflammation in cystic fibrosis (CF) patients similar to Pseudomonas aeruginosa and the Burkholderia cepacia complex (Bcc). Evolution in lung function was compared in chronically infected patients. Cytokine concentrations in CF patients with and without chronic infection were compared to healthy controls. Cytokines in serum and sputum were measured using multiplex bead based immunoassay. Sixty CF patients, 11 with A. xylosoxidans, 11 with Bcc, 21 with P. aeruginosa and 17 non-infected CF patients were compared to 11 healthy controls. A. xylosoxidans patients were younger, but had a FEV(1) decline similar to P. aeruginosa patients. Bcc patients had the steepest decline in FEV(1). Serum levels of G-CSF, IL-6 and TNF-alpha were significantly higher in CF patients compared to healthy controls. Chronically infected CF patients had significantly higher serum levels of IFN-gamma and IL-6 compared to non-infected CF patients. Bcc patients had significantly lower serum G-CSF and A. xylosoxidans patients had significantly higher sputum TNF-alpha compared to the other groups of chronically infected patients. A. xylosoxidans can cause a level of inflammation simil...Continue Reading

References

Jan 1, 1986·Annual Review of Microbiology·N HøibyP O Schiøtz
Feb 1, 1984·The Journal of Pediatrics·A IslesH Levison
Jan 1, 1995·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·A SchusterV Wahn
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·T Z KhanD W Riches
Jun 17, 1995·BMJ : British Medical Journal·D S ArmstrongP D Phelan
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·T L BonfieldM Berger
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·D S ArmstrongP D Phelan
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·L S NixonD J Shale
Jul 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J L BurnsC R Clausen
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·M S MuhlebachT L Noah
Aug 11, 2000·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C MoserN Høiby
Jul 12, 2002·Pediatric Pulmonology·Kenneth TanDaniel G Peckham
Sep 13, 2003·American Journal of Respiratory and Critical Care Medicine·Claudia L OrdoñezMoira L Aitken
Oct 1, 2003·The European Respiratory Journal·A M JonesA K Webb
Oct 14, 2003·American Journal of Respiratory and Critical Care Medicine·Ronald L GibsonBonnie W Ramsey
Dec 13, 2003·American Journal of Respiratory and Critical Care Medicine·Marie N BeckerScott H Randell
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·J M CourtneyJ S Elborn
Jan 28, 2005·Clinical and Experimental Medicine·A AugartenJ Yahav
Apr 29, 2005·Pediatric Pulmonology·Carla ColomboMassimo Conese
May 12, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jitka BrazovaHynek Lauschmann
Oct 7, 2005·Pediatric Pulmonology·David S ArmstrongKeith Grimwood
Mar 1, 2006·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·P Ø JensenN Høiby
Mar 21, 2006·Pediatric Pulmonology·Marianne S MuhlebachMargaret W Leigh
Jun 17, 2006·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Christine Rønne HansenMagdalena Gormsen
Jun 24, 2006·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Frans De BaetsMario Vaneechoutte
May 1, 2007·Pediatric Pulmonology·J M CourtneyJ S Elborn
Feb 7, 2008·Chest·Arnon ElizurThomas W Ferkol
Jul 8, 2008·International Journal of Pediatric Otorhinolaryngology·Brianne Barnett RobyJames Sidman
Sep 2, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L SpicuzzaM La Rosa
Sep 30, 2008·The Journal of Pediatrics·Scott D SagelUNKNOWN Cystic Fibrosis Foundation Therapeutics Development Network
Nov 26, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tiziana RasoDianella Savoia
May 7, 2009·Pediatric Pulmonology·Thomas BjarnsholtNiels Høiby

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Citations

Aug 29, 2012·Current Microbiology·German Matías TragliaMaría Soledad Ramírez
Jun 19, 2013·Current Microbiology·German Matías TragliaMaría Soledad Ramírez
Sep 27, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Kasper Aanæs
Aug 3, 2011·Antimicrobial Agents and Chemotherapy·Julien BadorCatherine Neuwirth
Oct 24, 2012·Antimicrobial Agents and Chemotherapy·Julien BadorCatherine Neuwirth
Jan 15, 2011·Clinical Microbiology Reviews·Alan R HauserSusanna A McColley
Jun 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Patrick ManckoundiaPierre Pfitzenmeyer
Jun 5, 2014·Current Microbiology·German TragliaMaría Soledad Ramírez
Jun 17, 2014·Life Sciences·Leticia Cristina Radin PereiraTânia Silvia Fröde
Feb 26, 2016·Molecular and Cellular Pediatrics·Andreas HectorDominik Hartl
Dec 6, 2011·Current Opinion in Microbiology·Máire Callaghan, Siobhán McClean
Jun 4, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·M WangN Nørskov-Lauritsen
Jun 19, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·C R HansenM Skov
Jun 5, 2013·Chembiochem : a European Journal of Chemical Biology·Flaviana Di LorenzoAntonio Molinaro
Sep 17, 2013·Pediatric Pulmonology·F De BaetsS Van Daele
Apr 19, 2011·Diagnostic Microbiology and Infectious Disease·Jane F TurtonDervla T Kenna
Sep 29, 2015·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Amy CowardJane F Turton
Mar 21, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Chloé DupontHélène Marchandin
Mar 24, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Rebeca P MantovaniTomomasa Yano
Jul 4, 2015·Enfermedades infecciosas y microbiología clínica·Laura Llorca OteroTeresa Alarcón Cavero
Mar 8, 2016·Expert Review of Respiratory Medicine·K A RamsayT J Kidd
Oct 5, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Ana Fernández-OlmosRafael Cantón
May 19, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Helle Krogh JohansenChristian von Buchwald
Dec 3, 2014·International Journal of Medical Microbiology : IJMM·Mette KolpenPeter Østrup Jensen
Aug 13, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Winnie RidderbergNiels Nørskov-Lauritsen
Sep 5, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Lucie AmoureuxCatherine Neuwirth
Jan 4, 2012·FEMS Immunology and Medical Microbiology·Vibeke B RudkjøbingThomas Bjarnsholt
Jun 29, 2010·FEMS Immunology and Medical Microbiology·Peter Østrup JensenClaus Moser
Apr 4, 2012·FEMS Immunology and Medical Microbiology·Luanne Hall-StoodleyThomas Bjarnsholt
Aug 30, 2016·Biotechnology and Bioengineering·Susana P LopesNuno F Azevedo
Apr 14, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Peter Ø JensenMichael Kühl
Apr 7, 2017·Genome Biology and Evolution·Julie JeukensRoger C Levesque
Feb 26, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C FirmidaA J Lopes
Dec 22, 2017·São Paulo Medical Journal = Revista Paulista De Medicina·Julia Carvalho VenturaYara Maria Franco Moreno

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