Inflammation in end-stage renal disease: the hidden enemy

Nephrology
Peter Stenvinkel

Abstract

Cardiovascular disease (CVD) remains the major cause of morbidity and mortality in end-stage renal disease (ESRD) patients. As traditional risk factors cannot alone explain the unacceptable high prevalence and incidence of CVD in this high-risk population, inflammation (interrelated to insulin resistance, oxidative stress, wasting and endothelial dysfunction) has been suggested to be a significant contributor. Indeed, several different inflammatory biomarkers, such as high sensitivity C-reactive protein (hs-CRP), have been shown to independently predict mortality in ESRD patients. As CRP is so strongly associated with vascular disease it has been suggested that this hepatic-derived protein is not only a marker, but also a mediator, of vascular disease. Although in vitro data from studies on endothelial cells, monocytes-macrophages and smooth muscle cells support a direct role for CRP in atherogenesis, data from studies performed in vivo have been controversial. The causes of the highly prevalent state of inflammation in ESRD are multiple, including inflammatory signals associated with the dialysis procedure, decreased renal function, volume overload, comorbidity and intercurrent clinical events. As the prevalence of inflammatio...Continue Reading

References

Mar 1, 1993·Kidney International·R SchindlerK M Koch
Jun 30, 1998·Journal of the American Society of Nephrology : JASN·J C Ayus, D Sheikh-Hamad
Jul 21, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R M BologaA L Rubin
Nov 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R N FoleyM J Sarnak
Feb 13, 1999·Kidney International·J ZimmermannC Wanner
Jun 3, 1999·Kidney International·J S WongJ T Daugirdas
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K IsekiK Fukiyama
Feb 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Y YeunG A Kaysen
Mar 15, 2000·Journal of the American College of Cardiology·A M FeldmanC McTiernan
Jul 8, 2000·Kidney International·A K CheungA S Levey
Jul 26, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T SitterH Schiffl
Mar 29, 2001·Journal of the American Society of Nephrology : JASN·Karen Ann HerzigDavid Wayne Johnson
Mar 29, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M Haubitz, R Brunkhorst
Aug 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H SchifflR Fischer
Jan 23, 2002·Blood Purification·Robert G CraigNathan W Levin
Feb 13, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bruno MemoliUNKNOWN Collaborative Study Group on SMC Membrane
Feb 13, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Peter StenvinkelTomas Jogestrand
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nancy G KutnerXavier Aviles
Aug 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roberto Pecoits-FilhoPeter Stenvinkel
Sep 11, 2002·Blood Purification·Marcelo M NascimentoPeter Stenvinkel
Sep 18, 2002·Kidney International·Didier DuclouxJean-Marc Chalopin
Sep 25, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Helmut SchifflRainald Fischer
Nov 20, 2002·Circulation·Penny M Kris-EthertonUNKNOWN American Heart Association. Nutrition Committee
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cheol Whee ParkByung Kee Bang
Mar 19, 2003·Seminars in Dialysis·Katrin UhligMark J Sarnak
May 31, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Roberto Pecoits-FilhoPeter Stenvinkel
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Michael AllonUNKNOWN HEMO Study Group
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vandana MenonMark J Sarnak
Jul 16, 2003·Journal of Internal Medicine·C ZoccaliM Buemi
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Martin J LandrayColin Baigent
Mar 3, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vincenzo PanichiCiro Tetta
Jul 1, 2004·Circulation·Veronica FrancoOscar A Carretero

❮ Previous
Next ❯

Citations

Feb 25, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Femke BaekeChantal Mathieu
Jun 11, 2008·Nature Clinical Practice. Nephrology·Nosratola D Vaziri
Jan 22, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jörg C SchefoldPetra Reinke
Apr 8, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sendogan AkerKatrin Ivens
May 27, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrzej BrymoraJacek Manitius
Jul 17, 2008·Seminars in Dialysis·Charles A HerzogRod Passman
Aug 12, 2008·American Journal of Nephrology·S M Kurt LeeRichard J Johnson
Nov 7, 2012·American Journal of Nephrology·Nosratola D VaziriKamyar Kalantar-Zadeh
Sep 25, 2009·The Tohoku Journal of Experimental Medicine·Sanja Simic-OgrizovicMilan Radovic
Apr 25, 2009·Journal of the American Society of Nephrology : JASN·Friso L H MuntingheFriedo W Dekker
Sep 6, 2008·Journal of Periodontology·Frank A Scannapieco, Mandip Panesar
Jul 26, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Juan F Navarro-GonzálezJavier García-Pérez
Oct 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Juan F Navarro-GonzálezJavier García
Nov 23, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Rajan K PatelAlan G Jardine
Apr 11, 2013·Nephro-urology Monthly·Bernard Canaud, Paungpaga Lertdumrongluk
Oct 12, 2013·Néphrologie & thérapeutique·Abdelouahab BouhabelAbdelhamid Aberkane
May 2, 2014·Seminars in Nephrology·Joachim JankowskiAlessandra F Perna
Jun 9, 2014·International Urology and Nephrology·Sena Memnune UluM Tugrul Sezer
Feb 5, 2013·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Seok Hui KangJun Young Do
Feb 27, 2008·Renal Failure·Effat RazeghiPatricia Khashayar
Aug 21, 2013·Advances in Medical Sciences·B NaumnikM Myśliwiec
Sep 12, 2015·Seminars in Dialysis·Gabriela CoboPeter Stenvinkel
Jan 21, 2016·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Dilek Aslan KutsalI Ozan Ütük
Jun 15, 2012·Kidney International·Marieke Roemeling-van RhijnMartin J Hoogduijn
Sep 25, 2009·Kidney International·Yujie CuiYiqing Zhou
Mar 1, 2012·Seminars in Nephrology·Andrew A House
Sep 13, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Tannaz KhabbaziParvin Pour-Abdollahi
Aug 13, 2011·General Hospital Psychiatry·Valjbona Tiric PreljevicToril Dammen
Sep 12, 2009·Diabetes Research and Clinical Practice·Friso L H MuntingheMike W Zuurman
Jun 27, 2009·Medical Hypotheses·Jirí SedýJana Dusková
Jan 6, 2009·Seminars in Nephrology·Ramnath Dukkipati, Joel D Kopple
Dec 20, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Richard J Glassock
Oct 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mohamed E SulimanPeter Stenvinkel
Nov 3, 2007·Pacing and Clinical Electrophysiology : PACE·Panagiotis KorantzopoulosJohn A Goudevenos
Feb 22, 2013·Journal of Clinical Pharmacology·Juan F Navarro-GonzálezCarmen Mora-Fernández

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

© 2021 Meta ULC. All rights reserved