Inflammation in induced sputum after aluminium oxide exposure: an experimental chamber study

Occupational and Environmental Medicine
Lib SikkelandJohny Kongerud

Abstract

Workers in aluminium production are exposed to a complex mixture of particles and gases potentially harmful to the airways, among them aluminium oxide (Al2O3). With the use of an exposure chamber, we aimed to examine the effects of short-term controlled exposure to Al2O3 on lung function and inflammatory markers in healthy volunteers. 15 men (age 19-31) were exposed in random order to clean air or Al2O3 particles (3.8-4.0 mg/m(3)) for 2 h including 30 min exercise (stationary bike, 75 W). The permissible exposure level (PEL) for Al2O3 by Occupational Safety and Health Administration, USA, is 5 mg/m(3) time weighted average (TWA). Sham and particle exposures were separated by at least 2 weeks. Spirometry was carried out, and induced sputum and blood samples were collected 48 h before and 4 and 24 h after exposure. Levels of sputum neutrophils (mean (±SEM)) was increased 24 h post-Al2O3 vs pre-Al2O3 exposure (43% (4) vs 31% (4), p=0.01) and the protein level of interleukin (IL)-8 had a 4.8 (0.9)-fold change increase 24 h after exposure (p<0.01). Following Al2O3 exposure, gene signatures in sputum were significantly increased related to several pathways. The present study suggests that controlled exposure to Al2O3 particles at lev...Continue Reading

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May 29, 2018·Journal of Internal Medicine·Maria Lerm, Hazel M Dockrell
Jul 23, 2020·Small·Mark R Miller, Craig A Poland
Jul 7, 2017·Current Treatment Options in Allergy·Agnieszka Lipińska-OjrzanowskaJolanta Walusiak-Skorupa
Jan 1, 2020·BMC Pulmonary Medicine·Christian MonséThomas Brüning

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