Inflammation in Parkinson's Disease: Mechanisms and Therapeutic Implications.

Cells
Marta PajaresAntonio Cuadrado

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia nigra pars compacta. Although the molecular bases for PD development are still little defined, extensive evidence from human samples and animal models support the involvement of inflammation in onset or progression. However, the exact trigger for this response remains unclear. Here, we provide a systematic review of the cellular mediators, i.e., microglia, astroglia and endothelial cells. We also discuss the genetic and transcriptional control of inflammation in PD and the immunomodulatory role of dopamine and reactive oxygen species. Finally, we summarize the preclinical and clinical approaches targeting neuroinflammation in PD.

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Citations

Oct 25, 2020·BioFactors·Duraisamy KempurajAsgar Zaheer
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Aug 26, 2021·Molecular Neurobiology·Bianca GugliettiLyndsey E Collins-Praino

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Methods Mentioned

BETA
nuclear translocation

Clinical Trials Mentioned

NCT01439100
NCT00063193
NCT03659682
NCT02267434
NCT03100149
NCT03958708
NCT03808389
NCT03633513
NCT03716258

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