Inflammation in psychiatric disorders: what comes first?

Annals of the New York Academy of Sciences
Moisés E Bauer, Antonio L Teixeira

Abstract

Neuropsychiatric disorders (i.e., mood disorders and schizophrenia) and inflammation are closely intertwined, and possibly powering each other in a bidirectional loop. Depression facilitates inflammatory reactions and inflammation promotes depression and other neuropsychiatric disorders. Patients with neuropsychiatric disorders exhibit all cardinal features of inflammation, including increased circulating levels of inflammatory inducers, activated sensors, and inflammatory mediators targeting all tissues. Inflammation may contribute to the pathophysiology and clinical progression of these disorders. Of note, proinflammatory cytokines modulate mood behavior and cognition by reducing brain monoamine levels, activating neuroendocrine responses, promoting excitotoxicity (increased glutamate levels), and impairing brain plasticity. What are the sources of this chronic inflammation? Increasing evidence indicates that changes in neuroendocrine regulation, metabolism, diet/microbiota, and negative health behaviors are important triggers of inflammation. Finally, recent data indicate that early-life stress is associated with overt inflammation prior to the development of neuropsychiatric disorders.

References

Mar 24, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M MaesS Scharpé
Mar 29, 2001·Biological Psychiatry·C M Pariante, A H Miller
Nov 26, 2002·Psychoneuroendocrinology·Moisés E BauerNola Shanks
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Angelika BierhausPeter P Nawroth
Dec 31, 2003·Trends in Immunology·Paresh DandonaArindam Bandyopadhyay
Jan 22, 2005·Psychiatry Research·Yong-Ku KimHarry W M Steinbusch
Jan 27, 2005·The Journal of Clinical Psychiatry·Charles L RaisonAndrew H Miller
Feb 3, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Jessica L GarnoBarry A Ritzler
Jan 18, 2006·Journal of Affective Disorders·Sinead M O'BrienTimothy G Dinan
Sep 12, 2007·Bipolar Disorders·Abigail Ortiz-DomínguezLenin Pavón
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Apr 16, 2008·Brain, Behavior, and Immunity·Mark Hamer, Emmanual Stamatakis
Jun 20, 2008·Biological Psychiatry·Michael R IrwinSteve Cole
Jul 8, 2008·Psychoneuroendocrinology·Christine HeimCharles B Nemeroff
Jan 20, 2009·Biological Psychiatry·Andrew H MillerCharles L Raison
Mar 3, 2009·Journal of Affective Disorders·Elisa BrietzkeFlávio Kapczinski
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ja Wook KooRonald S Duman
Mar 3, 2010·Archives of General Psychiatry·Floriana S LuppinoFrans G Zitman
Mar 23, 2010·Cell·Ruslan Medzhitov
Oct 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Linda L CarpenterLawrence H Price
Jun 7, 2011·Biological Psychiatry·Brian J MillerBrian Kirkpatrick
Sep 6, 2011·Physiology & Behavior·Andrea Danese, Bruce S McEwen
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sheldon CohenRonald B Turner
May 15, 2012·Brain, Behavior, and Immunity·Chiara BufalinoCarmine M Pariante
May 25, 2012·European Journal of Epidemiology·Marine Azevedo Da SilvaHermann Nabi
Aug 22, 2012·Biological Psychiatry·Iciar GárateJuan Carlos Leza
Sep 20, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Annamaria CattaneoCarmine M Pariante
Jan 10, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sophie ErhardtLena Brundin
Feb 20, 2013·Biological Psychiatry·Amirhossein ModabberniaMandana Ashrafi
Mar 5, 2013·European Archives of Psychiatry and Clinical Neuroscience·E OralN Aydin
Mar 21, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adam K WalkerRobert Dantzer
Jul 23, 2013·Journal of Affective Disorders·Vyara ValkanovaCharlotte L Allan
Jul 24, 2013·Brain, Behavior, and Immunity·Andrea WieckMoisés Evandro Bauer

❮ Previous
Next ❯

Citations

Nov 8, 2018·The European Journal of Neuroscience·Kyle D KetchesinColleen A McClung
Jul 4, 2019·Current Psychiatry Reports·Peter F Buckley
Nov 13, 2019·Journal of Clinical Pharmacy and Therapeutics·Fatemeh HendoueiShahin Akhondzadeh
Dec 14, 2018·Journal of Clinical Medicine·Karolina Skonieczna-ŻydeckaIgor Łoniewski
Jan 20, 2020·Journal of Neural Transmission·Hua Li, Szabolcs Kéri
Mar 20, 2020·Immunity & Ageing : I & a·Moisés E Bauer
Mar 22, 2020·Brain Sciences·Ilias I VlachosMaria Margariti
Aug 26, 2020·Cells·Benjamin B TournierPhilippe Millet
Jan 29, 2019·Frontiers in Psychiatry·Carsten CulmseeJudith Alferink
Apr 1, 2020·Journal of Receptor and Signal Transduction Research·Md Asad UllahMd Hasanur Rahman
May 25, 2020·Medical Microbiology and Immunology·Rebecca L GavinMichael G Tomlinson
Sep 13, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alessio SquassinaBernardo Carpiniello
Jul 19, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Antonio LeoRita Citraro
Jul 22, 2020·International Breastfeeding Journal·Kaisa M LinderborgHenna-Maria Uusitupa
Aug 28, 2020·Journal of Immunology Research·Daria A ParshukovaSvetlana A Ivanova
Jan 12, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Tamara BerdyyevaAnna Katrin Szardenings
Jan 29, 2019·Frontiers in Molecular Neuroscience·Laura OrioBorja García-Bueno
Jun 17, 2020·BMC Psychiatry·Arthi Chinna MeyyappanRoumen Milev
Jul 1, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·B NobileP Courtet
Oct 6, 2020·Brain and Neuroscience Advances·Nichola M Brydges, Jack Reddaway
Oct 26, 2018·Nutrients·Bethan DaltonHubertus Himmerich
Apr 29, 2019·Journal of Neurology·Harm Jan van der HornJoukje van der Naalt
Sep 19, 2019·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Mary I ButlerTimothy G Dinan
Oct 19, 2020·The European Journal of Neuroscience·Harry PantazopoulosSabina Berretta
Nov 17, 2020·Frontiers in Psychiatry·Evgeniia GolovinaJustin M O'Sullivan
Dec 3, 2020·Journal of Clinical Medicine·Yoann MaitreFrederic Denis
Nov 13, 2020·Expert Opinion on Therapeutic Targets·Mohammad BadranDavid Gozal
Dec 9, 2020·Molecular Psychiatry·Carina CarbiaJohn F Cryan
Feb 25, 2020·Neuroscience and Biobehavioral Reviews·Kimberley J SmithChristina Victor
Jan 26, 2021·Journal of Biological Rhythms·N Kronfeld-SchorB Helm
Sep 25, 2020·Journal of Affective Disorders·Guido CeredaPaolo Brambilla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.