Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling

Therapeutic Advances in Neurological Disorders
Abraham MartínCarlos Matute

Abstract

The inflammatory response is a major factor in stroke pathophysiology and contributes to secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent work in experimental cerebral ischemia has demonstrated the involvement of neurotransmitter signaling in the modulation of neuroinflammation. The present review discusses recent findings on the therapeutic potential and diagnostic perspectives of cholinergic, purinergic and glutamatergic receptors and transporters in experimental stroke. It provides evidence of the role of neurotransmission signaling as a promising inflammatory biomarker in stroke. Finally, recent molecular imaging studies using positron emission tomography of cholinergic receptors and glutamatergic transporters are outlined along with their potential as novel anti-inflammatory therapy to reduce the outcome of cerebral ischemia.

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Citations

Feb 7, 2020·Journal of Stroke·Shi-Chun BaoRaymond Kai-Yu Tong
Jan 1, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·L T KhasanovaN A Shamalov
Aug 22, 2018·Journal of Experimental Neuroscience·Diana I Lurie
May 18, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dong Young KimYoung-Guen Kwon
Sep 15, 2020·Brain, Behavior, and Immunity·Amanda CostaHelmut Kettenmann
Feb 28, 2021·Journal of Neurochemistry·Katarzyna WinekAndreas Meisel
Mar 24, 2021·Pharmacology & Therapeutics·Juan C Sanchez-AriasLeigh Anne Swayne
May 29, 2019·European Journal of Pharmacology·Angela María Barrera-SandovalGloria Patricia Cardona-Gómez
Aug 2, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yu YuanChunhui Li

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