Mar 17, 2020

Inflammation in Traumatic Brain Injury

Journal of Alzheimer's Disease : JAD
Teodor T PostolacheJohn W Stiller

Abstract

There is an increasing evidence that inflammation contributes to clinical and functional outcomes in traumatic brain injury (TBI). Many successful target-engaging, lesion-reducing, symptom-alleviating, and function-improving interventions in animal models of TBI have failed to show efficacy in clinical trials. Timing and immunological context are paramount for the direction, quality, and intensity of immune responses to TBI and the resulting neuroanatomical, clinical, and functional course. We present components of the immune system implicated in TBI, potential immune targets, and target-engaging interventions. The main objective of our article is to point toward modifiable molecular and cellular mechanisms that may modify the outcomes in TBI, and contribute to increasing the translational value of interventions that have been identified in animal models of TBI.

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Mentioned in this Paper

Symptom Control (Regime/Therapy)
Clinical Trials
Immune Response
Immune System
Direction
Cellular Response to Mechanical Stimulus
Brain Injuries
Inflammation

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