Inflammation induced preterm labor and birth

Journal of Reproductive Immunology
Alice Gilman-SachsKenneth Beaman

Abstract

Preterm birth which occurs before 37 weeks gestation is one of the most common obstetrical complication in humans. After many studies, it appears that "not one answer fits all" regarding the risk factors, causes and the treatments for this syndrome. However, it is becoming more evident that one of the major risk factors is inflammation and/or infection in the fetoplacental unit. In animal models (usually consisting of mice injected with lipopolysaccharide at 14 days of gestation), IL-22 and IL-6 have been identified as factors related to preterm birth. There are some clinical tests available to determine the risk for preterm labor and delivery, which can be identified before, during early, or at mid-gestation. However, treatment of preterm birth with antibiotics so far has not been "curable" and studies using anti-inflammatory treatments are not readily available. More studies regarding causes and treatments for preterm labor and delivery in humans are necessary to prevent neonatal deaths and/or developmental abnormalities associated with this common syndrome.

Citations

May 10, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·Susanne HesselmanAnna-Karin Wikström
Sep 10, 2020·Birth Defects Research·Aleksandra Polić, Sarah G Običan
Jul 8, 2020·Scientific Reports·Kazushige NakaharaUNKNOWN Japan Environment and Children’s Study Group
May 24, 2019·Scientific Reports·Omar LakhdariLawrence S Prince
Jan 2, 2020·BMC Pregnancy and Childbirth·Letícia Veríssimo DutraBianca Bianco
Oct 3, 2020·Cells·Morsal SabihiSamuel Huber
Jun 18, 2020·Journal of Inflammation Research·Sedigheh HantoushzadehAmir Hossein Norooznezhad
Dec 21, 2020·Environment International·Youngrin KwagEun-Hee Ha
Jan 24, 2021·Birth Defects Research·Víctor Manuel Muñoz-PérezMario Hernándes-Alejandro
Feb 10, 2021·International Journal of Environmental Research and Public Health·Youngrin KwagEunhee Ha
May 1, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·María De Lourdes Márquez-CoronaCarlo Eduardo Medina-Solís
Dec 18, 2020·Frontiers in Immunology·João MendesAnabela Mota-Pinto
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May 21, 2021·Clinical Genetics·Joana CouceiroAlexandre Quintas
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May 25, 2021·Acta Paediatrica·Olaf DammannSylvain Chemtob
Nov 2, 2021·Frontiers in Immunology·Anders Hagen JarmundAnn-Charlotte Iversen

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