Inflammation, Infection and Venous Thromboembolism.

Circulation Research
Meaghan E CollingYogendra Kanthi

Abstract

The association between inflammation, infection, and venous thrombosis has long been recognized; yet, only in the last decades have we begun to understand the mechanisms through which the immune and coagulation systems interact and reciprocally regulate one another. These interconnected networks mount an effective response to injury and pathogen invasion, but if unregulated can result in pathological thrombosis and organ damage. Neutrophils, monocytes, and platelets interact with each other and the endothelium in host defense and also play critical roles in the formation of venous thromboembolism. This knowledge has advanced our understanding of both human physiology and pathophysiology, as well as identified mechanisms of anticoagulant resistance and novel therapeutic targets for the prevention and treatment of thrombosis. In this review, we discuss the contributions of inflammation and infection to venous thromboembolism.

References

Aug 1, 1985·Thrombosis Research·M Jörg, B R Binder
Sep 1, 1974·The Journal of Experimental Medicine·D C Morrison, C G Cochrane
Jul 14, 1999·Molecular Immunology·M Kirschfink, W Nürnberger
Aug 8, 2001·The Journal of Cell Biology·S LindemannA S Weyrich
Jan 16, 2002·Current Opinion in Immunology·Sadaaki Iwanaga
Dec 31, 2002·The Journal of Surgical Research·Daniel MyersThomas Wakefield
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jen-Tsan ChiPatrick O Brown
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shenghe Cai, Alvin E Davis
Mar 6, 2004·Science·Volker BrinkmannArturo Zychlinsky
May 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jae-Kwon LeeCharles A Dinarello
Aug 11, 2004·The Journal of Biological Chemistry·Sibylla MartinelliShida Yousefi
Jul 13, 2005·The Journal of Experimental Medicine·Thomas RennéBernhard Nieswandt
Aug 17, 2005·Journal of Vascular Surgery·Daniel D MyersThomas W Wakefield
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stephanie A SmithJames H Morrissey
Feb 14, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Mariska G RondaijJan Voorberg
Feb 24, 2006·Blood·Gabriela Cesarman-MausKatherine A Hajjar
Dec 23, 2006·American Journal of Human Genetics·Sven CichonMarkus M Nöthen
Jan 11, 2007·The Journal of Cell Biology·Tobias A FuchsArturo Zychlinsky
Oct 22, 2008·Annual Review of Pathology·Grace ChenGabriel Nuñez
Nov 4, 2008·Platelets·Zakar MnjoyanVahid Afshar-Kharghan
May 14, 2009·Blood·Erin G BrooksEdwin G Bovill
May 19, 2009·Nature Medicine·Kai KessenbrockDieter E Jenne
Feb 13, 2010·European Journal of Medical Research·Klaus F Hofmann-KieferM Rehm
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Abdul HakkimArturo Zychlinsky
Aug 19, 2010·Blood·Björn PetriDietmar Vestweber
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tobias A FuchsDenisa D Wagner
Nov 3, 2010·Annual Review of Physiology·Edwin G Bovill, Albert van der Vliet
Nov 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Florian H PilsczekPaul Kubes
Jan 5, 2011·Stroke; a Journal of Cerebral Circulation·Gabriela Cesarman-MausEthel Garcia Latorre

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Citations

Jun 11, 2021·Circulation Research·Nicholas J Leeper, Naomi M Hamburg

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