Inflammation, insulin resistance and carotid IMT in first degree relatives of north Indian type 2 diabetic subjects

Diabetes Research and Clinical Practice
Jamal AhmadIbne Ahmad

Abstract

Inflammation is associated with insulin resistance, atherosclerosis and type 2 diabetes but whether it causes insulin resistance and accelerated atherosclerosis or an epiphenomena of insulin resistance is not clear. Thirty-eight young normoglycemic, non-obese, first degree relatives of type 2 diabetic subjects (FH(+)) and 38 control subjects without family history of diabetes (FH(-)) (age and sex matched), were studied to determine difference in inflammatory markers, insulin resistance and carotid intima-media thickness (IMT). Plasma glucose, insulin (fasting and 2h after 75gm oral glucose) lipids and serum levels of C-reactive protein (CRP), tumour necrosis factor (TNF)-alpha and fibrinogen were measured after an overnight fast of 10-12h. First degree relative group (FH(+)) have higher BMI (p<0.05), composite IMT (p<0.05) and CRP level (p<0.05), however, after adjustment for BMI, the two groups did not significantly differ. Fibrinogen was not significantly correlated with composite IMT in FH(+) group after controlling with BMI. In FH(+) group composite IMT was significantly correlated with systolic blood pressure (p<0.05), LDL-cholesterol (p<0.05), postprandial insulin level (p<0.05) and HOMA-IR (p<0.05) after adjustment of BM...Continue Reading

References

Jul 1, 1995·Diabetes Care·M W StewartM Walker
Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·P DandonaT Wadden
Oct 30, 1998·Diabetologia·J C Pickup, M A Crook
Jul 31, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N PannacciulliR Giorgino
Sep 6, 2003·The American Journal of Cardiology·Steven M Haffner
Mar 11, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·M Crook

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Citations

Nov 4, 2008·Biological Trace Element Research·Mesut OzkayaMetin Kilinc
Aug 15, 2015·BioMed Research International·Siyi ZhangJing Li
Apr 28, 2012·International Journal of Cardiology·Anita KhalilUNKNOWN New Delhi Birth Cohort
Jul 14, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Arunkumar R PandePreeti Dabadghao
Oct 16, 2007·Annals of Medicine·Damiano BaldassarreCesare R Sirtori
Jul 3, 2021·Journal of Personalized Medicine·Anna Maria RychterIwona Krela-Kaźmierczak
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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