Inflammation is a key risk factor for persistent seizures in neurocysticercosis

Annals of Clinical and Translational Neurology
Jesica A HerrickCysticercosis Working Group in Perú

Abstract

We conducted a retrospective, case-control study of neurocysticercosis patients to ascertain early markers that identify subjects likely to develop treatment-resistant seizures. Clinical histories and imaging studies from 38 neurocysticercosis patients who had been followed for 18 months after treatment were evaluated. Both pairwise and multifactorial analyses were conducted to identify factors associated with continued seizures. Eleven of 38 patients continued to have seizures during the follow-up period. On univariate analysis, the number of neurocysticercosis lesions, number of bands on the baseline neurocysticercosis western blot, edema volumes on follow-up MRI scans, edema volume changes between baseline and follow-up images, and proportion of calcified lesions with perilesional edema were all significantly increased in subjects who had persistent seizures during the 18-month follow-up period. On multivariate analyses using recursive partition and random forest algorithms, variables associated with persistent seizures included: the number of total and calcified lesions, presence of perilesional edema, the rate of change in the lesion and edema volumes from baseline to follow-up, and the number of bands on the neurocysticer...Continue Reading

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Citations

May 21, 2020·The American Journal of Tropical Medicine and Hygiene·Jesica A Herrick For The Cysticercosis Working Group In Peru
Jul 4, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christina M Coyle
Jun 20, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Javier A BustosUNKNOWN Cysticercosis Working Group in Peru
Aug 28, 2019·The American Journal of Tropical Medicine and Hygiene·Abhijit ModakNiranjan Khandelwal
Sep 2, 2020·Current Opinion in Infectious Diseases·Javier A Bustos, Christina M Coyle
May 29, 2020·Clinical Microbiology Reviews·Hector H GarciaRobert H Gilman
Dec 22, 2020·PLoS Neglected Tropical Diseases·Anja de LangeJoseph Valentino Raimondo
Nov 11, 2019·Seizure : the Journal of the British Epilepsy Association·Donald P CraigRhys H Thomas
Apr 2, 2021·Expert Review of Anti-infective Therapy·Pedro T Hamamoto FilhoAgnès Fleury
Jun 23, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Prabhakaran VasudevanVedantam Rajshekhar

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