Inflammation is associated with decreased functional connectivity of insula in unmedicated bipolar disorder.

Brain, Behavior, and Immunity
Pan ChenYing Wang

Abstract

Systemic inflammation and immune dysregulation have been considered as risk factors in the pathophysiology of mood disorders including bipolar disorder (BD). Previous neuroimaging studies have demonstrated metabolic, structural and functional abnormalities in the insula in BD, proposed that the insula played an important role in BD. We herein aimed to explore neural mechanisms underlying inflammation-induced in the insular subregions functional connectivity (FC) in patients with BD. Brain resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 41 patients with unmedicated BD II (current episode depressed), 68 healthy controls (HCs). Three pairs of insular seed regions were selected: the bilateral anterior insula (AI), the bilateral middle insula (MI) and the bilateral posterior insula (PI), and calculated the whole-brain FC for each subregion. Additionally, the serum levels of pro-inflammatory cytokines in patients and HCs, including IL-6 and TNF-α, were detected. Then the partial correlation coefficients between the abnormal insular subregions FC values and pro-inflammatory cytokines levels in patients with BD II depression were calculated. The BD II depression group exhibited decreased FC between...Continue Reading

References

Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Oct 1, 1996·Brain Research. Brain Research Reviews·J R Augustine
Aug 11, 2000·Chest·C A Dinarello
Nov 16, 2004·Bipolar Disorders·Philip B Mitchell, Gin S Malhi
Jan 18, 2006·Bipolar Disorders·In Kyoon LyooPerry F Renshaw
Aug 11, 2006·Arthritis Research & Therapy·Cem Gabay
Aug 8, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·N M SimonK K Wong
Dec 17, 2008·Human Brain Mapping·Keri S TaylorKaren D Davis
Aug 1, 2009·Trends in Cognitive Sciences·Tania SingerKerstin Preuschoff
Jan 15, 2010·Schizophrenia Research·Ian Ellison-Wright, Ed Bullmore
Mar 17, 2010·Brain, Behavior, and Immunity·Aoife O'DonovanKevin M Malone
Nov 26, 2010·Cerebral Cortex·Ben DeenKevin A Pelphrey
Feb 22, 2011·Pharmacology & Therapeutics·Lucile Capuron, Andrew H Miller
Sep 13, 2011·Trends in Cognitive Sciences·Vinod Menon
Mar 17, 2012·Bipolar Disorders·Sudhakar SelvarajAndrew M McIntosh
Feb 20, 2013·Biological Psychiatry·Amirhossein ModabberniaMandana Ashrafi
Jun 19, 2013·Journal of Psychiatric Research·Klaus MunkholmMaj Vinberg
Sep 3, 2013·NeuroImage·Jonathan D PowerSteven E Petersen
Oct 2, 2013·The Journal of Nervous and Mental Disease·Benny LibergBjörn Wahlund
Oct 15, 2013·Journal of Affective Disorders·Ke XuFei Wang
Jul 6, 2014·Cytokine·Janina WolfChristoph Garbers
Sep 6, 2014·Journal of Affective Disorders·Jerome J MallerPaul B Fitzgerald
Nov 19, 2014·Frontiers in Psychiatry·Moon-Soo LeeMani N Pavuluri
Nov 20, 2014·Nature Reviews. Neuroscience·Lucina Q Uddin
Dec 3, 2014·Neuropharmacology·Donna L Gruol
Dec 10, 2015·Journal of Psychiatry & Neuroscience : JPN·Christoph AbéMikael Landén
Dec 24, 2015·Frontiers in Psychology·Ajay B SatputeLisa F Barrett

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Citations

Dec 29, 2020·Journal of Psychiatric Research·Nan ChenBin Hu
Aug 13, 2021·Frontiers in Psychiatry·Peifen ZhangShaohua Hu
Aug 25, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jessica S FlanneryMatthew T Sutherland

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