Inflammation-linked adaptations in dermal microvascular reactivity accompany the development of obesity and type 2 diabetes.

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Marie-Sophie Nguyen-TuDominique Sigaudo-Roussel

Abstract

The increased prevalence of obesity has prompted great strides in our understanding of specific adipose depots and their involvement in cardio-metabolic health. However, the impact of obesity on dermal white adipose tissue (dWAT) and dermal microvascular functionality remains unclear. This study aimed to investigate the temporal changes that occur in dWAT and dermal microvascular functionality during the development of diet-induced obesity and type 2 diabetes in mice. Metabolic phenotyping of a murine model of hypercaloric diet (HCD)-induced obesity and type 2 diabetes was performed at three time points that reflected three distinct stages of disease development; 2 weeks of HCD-overweight-metabolically healthy, 4 weeks of HCD-obese-prediabetic and 12 weeks of HCD-obese-type 2 diabetic mice. Expansion of dWAT was characterized histologically, and changes in dermal microvascular reactivity were assessed in response to pressure and the vasodilators SNP and Ach. HCD resulted in a progressive expansion of dWAT and increased expression of pro-inflammatory markers (IL1β and COX-2). Impairments in pressure-induced (PIV) and Ach-induced (endothelium-dependent) vasodilation occurred early, in overweight-metabolically healthy mice. Residu...Continue Reading

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Citations

Jul 25, 2019·Frontiers in Physiology·Maxime FouchardBérengère Fromy
Oct 3, 2020·International Journal of Molecular Sciences·Kyeongho Byun, Sewon Lee
Aug 23, 2020·Scientific Reports·Jeanne M WalkerPeter R Holt

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BETA
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Metaview
Adiposoft
GraphPad
GraphPad Prism

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