Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family

Immunological Reviews
Cees J TackMihai G Netea

Abstract

A growing body of evidence suggests that cytokines of the interleukin-1 (IL-1) family, particularly IL-1β but also IL-1Ra and IL-18, are involved in obesity-associated inflammation. IL-1β is produced via cleavage of pro-IL-1β by caspase-1, which in turn is activated by a multiprotein complex called the inflammasome. The components of the NLRP3 inflammasome are involved in sensing obesity-associated danger signals, both in mice and in human (obese) subjects, with caspase-1 seemingly the most crucial regulator. Autophagy is upregulated in obesity and may function as a mechanism to control IL-1β gene expression in adipose tissue to mitigate chronic inflammation. All these mechanisms are operative in human adipose tissue and appear to be more pronounced in human visceral compared to subcutaneous tissue. In animal studies, blocking caspase-1 activity results in decreased weight gain, decreased inflammation, and improved insulin sensitivity. Human intervention studies with IL-1Ra (anakinra) have reported beneficial effects in patients with diabetes, yet without significant changes in insulin sensitivity. Clearly, the IL-1 family of cytokines, especially IL-1β, plays an important role in obesity-associated inflammation and insulin res...Continue Reading

References

Aug 1, 1977·The Journal of Clinical Investigation·Charles A DinarelloS M Wolff
Jun 1, 1990·Diabetes Care·L RossettiRalph A Defronzo
Jan 1, 1986·Diabetologia·Thomas Mandrup-PoulsenJ H Nielsen
Jan 5, 2002·Expert Opinion on Investigational Drugs·J C RandleR Kurrle
Jan 15, 2003·The Journal of Biological Chemistry·Jose Antonio ChavezScott A Summers
Sep 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jens M BruunBjørn Richelsen
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Héctor F Escobar-MorrealeJosé L San Millán
Mar 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Joseph HungJohn P Beilby
Jun 28, 2005·Current Opinion in Cell Biology·Fulvio Reggiori, Daniel J Klionsky
Oct 13, 2005·Diabetes, Obesity & Metabolism·M Krebs, M Roden
Jan 13, 2006·Nature·Thirumala-Devi KannegantiGabriel Nuñez
Jan 13, 2006·Nature·Fabio MartinonJurg Tschopp
Jan 13, 2006·Nature·Sanjeev MariathasanVishva M Dixit
May 30, 2006·Nature Medicine·Mihai G NeteaJos van der Meer
Oct 21, 2006·The Journal of Clinical Investigation·Hang ShiJeffrey S Flier
Mar 16, 2007·Annals of the Rheumatic Diseases·Frank C HuversCees J Tack
Apr 13, 2007·The New England Journal of Medicine·Claus M LarsenMarc Donath
Apr 21, 2007·Metabolism: Clinical and Experimental·Simon R ThompsonSteve E Humphries
Apr 26, 2007·Diabetes·Patrice D CaniRémy Burcelin
May 3, 2007·PLoS Medicine·Hemang ParikhVamsi K Mootha
Jun 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Eric P ZorrillaBruno Conti
Jul 20, 2007·The New England Journal of Medicine·Saul Malozowski, Jon Todd Sahlroot
Sep 19, 2007·Journal of Leukocyte Biology·Jeanette M WilmanskiKoichi S Kobayashi
Nov 6, 2007·Current Opinion in Immunology·Virginie PétrilliJurg Tschopp
Nov 14, 2007·The Journal of Biological Chemistry·William A ChutkowRichard T Lee
Feb 19, 2008·Current Opinion in Immunology·Zhengmao Ye, Jenny Pan-Yun Ting
Mar 6, 2008·The Journal of Clinical Endocrinology and Metabolism·Amélie CartierJean-Pierre Després
Mar 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Simon T Y HuiRoger A Davis
May 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Carrie A StoltzmanDonald E Ayer
May 13, 2008·The American Journal of Clinical Nutrition·Jacques AmarJean Ferriéres
May 13, 2008·Current Opinion in Cell Biology·Tamotsu Yoshimori, Takeshi Noda
Jul 23, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·G R C ZilverschoonMihai G Netea
Jul 29, 2008·Biochemical and Biophysical Research Communications·Jianping Ye
Aug 1, 2008·Molecular & Cellular Proteomics : MCP·Mohamed LamkanfiGabriel Nuñez
Aug 30, 2008·Endocrine Reviews·Norbert StefanHans-Ulrich Häring
Sep 5, 2008·The Journal of Clinical Investigation·Simon SchenkJerrold M Olefsky
Jan 6, 2009·Immunological Reviews·Monica DelgadoVojo Deretic
Mar 24, 2009·Annual Review of Immunology·Charles A Dinarello
Jun 23, 2009·Diabetes Care·Claus M LarsenThomas Mandrup-Poulsen
Aug 8, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Clett Erridge, Nilesh J Samani
Oct 6, 2009·Current Topics in Microbiology and Immunology·Monique Gannagé, Christian Münz
Oct 7, 2009·The Journal of Cell Biology·Mohamed LamkanfiVishva M Dixit
Oct 27, 2009·The Journal of Clinical Investigation·Rajat SinghMark J Czaja
Nov 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yong ZhangShengkan Jin
Dec 22, 2009·Nature Immunology·Rongbin ZhouJurg Tschopp
Jan 16, 2010·Science·Kate SchroderJurg Tschopp
Feb 13, 2010·Annual Review of Physiology·Jerrold M Olefsky, Christopher K Glass
Apr 20, 2010·Annals of the New York Academy of Sciences·Miguel A Gonzalez-GayJavier Llorca
May 7, 2010·Cell Metabolism·Ele Ferrannini
May 13, 2010·Digestive Diseases·Hannele Yki-Järvinen
May 14, 2010·Postgraduate Medicine·Jeff Unger, Christopher G Parkin
Jul 1, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Charles A DinarelloThomas Mandrup-Poulsen
Sep 3, 2010·Nature Cell Biology·Noboru Mizushima, Beth Levine
Sep 30, 2010·The Journal of Clinical Investigation·Aliki KosteliAnthony W Ferrante
Oct 5, 2010·Trends in Endocrinology and Metabolism : TEM·A Christine Könner, Jens C Brüning
Oct 21, 2010·Nature Immunology·Charles A DinarelloChiristopher Gabel
Nov 5, 2010·The Journal of Clinical Endocrinology and Metabolism·Julia KovsanAssaf Rudich
Dec 16, 2010·Archives of Biochemistry and Biophysics·Yoshimi FujishimaMasaru Yoshida
Jan 5, 2011·Cell Metabolism·Rebecca G BakerSankar Ghosh
Jan 11, 2011·Nature Medicine·Bolormaa VandanmagsarVishwa D Dixit
Jan 12, 2011·Annual Review of Immunology·Margaret F Gregor, Gökhan S Hotamisligil
Jan 14, 2011·The Journal of Biological Chemistry·James HarrisEd C Lavelle
Jan 22, 2011·Nature Reviews. Immunology·Noriyuki OuchiKenneth Walsh
Mar 1, 2011·Trends in Endocrinology and Metabolism : TEM·Thomas Greiner, Fredrik Bäckhed
Mar 8, 2011·The Journal of Allergy and Clinical Immunology·Mübeccel AkdisCezmi A Akdis
Mar 25, 2011·Biochemical Society Transactions·Aisling Dunne
Apr 2, 2011·The Journal of Biological Chemistry·Jaewoo HongSoohyun Kim
Jun 3, 2011·The Journal of Clinical Investigation·Carey N Lumeng, Alan R Saltiel
Jul 19, 2011·Clinical and Experimental Immunology·P Menu, J E Vince
Aug 23, 2011·The Medical Clinics of North America·Gerald M Reaven
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Rinke StienstraThirumala-Devi Kanneganti
Nov 4, 2011·European Cytokine Network·Diana BoraschiCharles A Dinarello
Jan 10, 2012·Cell Metabolism·Rinke StienstraMihai G Netea
Mar 6, 2012·Cell·Varman T Samuel, Gerald I Shulman
Mar 8, 2012·Nature Medicine·Olivia Osborn, Jerrold M Olefsky
Mar 28, 2012·Annual Review of Immunology·Petric KuballaR J Xavier

Citations

Jun 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sanjeev Kumar UpadhyayK George Chandy
Dec 28, 2012·American Journal of Physiology. Endocrinology and Metabolism·Jianping Ye, Owen P McGuinness
Mar 7, 2013·The Journal of Endocrinology·Annemarie GagnonAlexander Sorisky
Oct 2, 2013·Indian Journal of Endocrinology and Metabolism·Faranak SharifiNouraddin Mousavinasab
May 24, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Monika Moll, Jasmin B Kuemmerle-Deschner
Nov 30, 2013·Cellular and Molecular Life Sciences : CMLS·Antero SalminenKai Kaarniranta
Nov 6, 2013·BioMed Research International·Yong SonHyun-Ock Pae
Mar 13, 2014·Journal of Nephrology·Adriana M HungTalat Alp Ikizler
May 28, 2013·Expert Opinion on Investigational Drugs·Thomas Mandrup-Poulsen, AIDA study group
Oct 28, 2014·Expert Opinion on Investigational Drugs·Nathalie EsserAndré J Scheen
Jul 15, 2015·International Journal of Molecular Medicine·Kyung-Ah Cho, Peter B Kang
Feb 7, 2014·Canadian Journal of Diabetes·Matti Uusitupa, Ursula Schwab
Jun 16, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Edwin J P van AsseldonkCees J Tack
Aug 15, 2012·Immunological Reviews·Jeffrey C Rathmell
Feb 24, 2015·Immunological Reviews·Katharina RonacherTom H M Ottenhoff
Jul 22, 2015·Ageing Research Reviews·Jung Jae ShinWook Kim
Jul 25, 2015·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Sergio Martinez-HervasJuan F Ascaso
Jun 19, 2015·Immunological Reviews·Fiachra Humphries, Paul N Moynagh
May 30, 2015·Trends in Pharmacological Sciences·Mathias Fasshauer, Matthias Blüher
Apr 17, 2015·Journal of Molecular Endocrinology·Ciro MenaleDamiano Gustavo Mita
Sep 24, 2013·Molecular and Cellular Endocrinology·Martha Lappas
Apr 22, 2016·Genome Medicine·Claire L BoulangéMarc-Emmanuel Dumas
Dec 18, 2013·Immunity·Cecilia GarlandaAlberto Mantovani
Jun 21, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Aoife M MurphyHelen M Roche
May 2, 2014·Frontiers in Immunology·George Nikov ChaldakovLuigi Aloe
Apr 23, 2016·Tropical Medicine & International Health : TM & IH·Damiano PizzolAnnalisa Saracino
Jun 24, 2016·American Journal of Reproductive Immunology : AJRI·Kristian LeisegangRalf R Henkel
Apr 21, 2016·The Journal of Endocrinology·Haijiang WuHuijun Duan
Jan 17, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Herbert TilgGyongyi Szabo
Sep 4, 2014·Nature Communications·Dov B BallakRinke Stienstra
Apr 20, 2018·Journal of Diabetes Research·Joselyn RojasManuel Velasco
Nov 24, 2018·Expert Review of Proteomics·Roel TansAlain J van Gool
Jan 18, 2018·Scientific Reports·Anping SongNing Quan
Dec 27, 2018·Journal of Pineal Research·María Elisa MercauCora Beatriz Cymeryng
Feb 2, 2019·The Proceedings of the Nutrition Society·Helen M Roche
Dec 2, 2015·Molecular Medicine·Fausto ChiazzaMassimo Collino
Apr 21, 2018·Nature Communications·Fiachra HumphriesPaul N Moynagh
Jun 11, 2014·The Journal of Clinical Endocrinology and Metabolism·Kiymet BozaogluJeremy B M Jowett
Jun 12, 2014·American Journal of Physiology. Endocrinology and Metabolism·Dan GaoChen Bing
Jul 6, 2017·Frontiers in Human Neuroscience·Yun-Zi LiuChun-Lei Jiang
Oct 11, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yihui ChenGuangxun Meng
Aug 20, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Yuxing LiuFang Wang
Mar 12, 2020·Journal of Food Biochemistry·María Luisa Ávila-EscalanteIrma Isela Aranda-González
Jun 9, 2019·Journal of Neuroinflammation·Pu HongHong-Fei Zhang
Feb 5, 2020·Experimental and Therapeutic Medicine·Qingxin YangNan Zeng
Oct 16, 2013·Biological Chemistry·Jérôme LugrinLucas Liaudet
Aug 11, 2020·British Journal of Pharmacology·Ilaria BertocchiMassimo Collino
Jan 7, 2016·American Journal of Physiology. Endocrinology and Metabolism·Tao BaiLu Cai
Oct 12, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Roel TansAlain J van Gool
Mar 14, 2020·Cell & Bioscience·Danwen WangZhiling Sun
Aug 23, 2017·Annual Review of Nutrition·Jessica C RalstonHelen M Roche
Jan 18, 2017·Frontiers in Public Health·Philip B MaffetonePaul B Laursen
Aug 2, 2018·Frontiers of Medicine·Ning JiangJing Wang
Sep 6, 2019·International Journal of Endocrinology·Fang WangZhaohui Mo
Oct 20, 2020·Frontiers in Immunology·Bhagirath ChaurasiaScott A Summers
Oct 30, 2020·Journal of Developmental Origins of Health and Disease·Yamila Raquel JuárezAdriana Laura Burgueño
Sep 22, 2020·American Journal of Physiology. Endocrinology and Metabolism·Patrick MunroDidier F Pisani
Jun 20, 2017·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Xiang ShuXifeng Wu

Related Concepts

NLRP3 protein, human
Programmed Cell Death, Type II
Carrier Proteins
Inflammation
Insulin Sensitivity
Interleukin-1
Obesity
Procaspase-1
Interleukin-18
Subcutaneous Fat

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.