Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis.

PloS One
Do Young KimJong M Rho

Abstract

A prominent clinical symptom in multiple sclerosis (MS), a progressive disorder of the central nervous system (CNS) due to heightened neuro-inflammation, is learning and memory dysfunction. Here, we investigated the effects of a ketogenic diet (KD) on memory impairment and CNS-inflammation in a murine model of experimental autoimmune encephalomyelitis (EAE), using electrophysiological, behavioral, biochemical and in vivo imaging approaches. Behavioral spatial learning deficits were associated with motor disability in EAE mice, and were observed concurrently with brain inflammation. The KD improved motor disability in the EAE model, as well as CA1 hippocampal synaptic plasticity (long-term potentiation) and spatial learning and memory (assessed with the Morris Water Maze). Moreover, hippocampal atrophy and periventricular lesions in EAE mice were reversed in KD-treated EAE mice. Finally, we found that the increased expression of inflammatory cytokines and chemokines, as well as the production of reactive oxygen species (ROS), in our EAE model were both suppressed by the KD. Collectively, our findings indicate that brain inflammation in EAE mice is associated with impaired spatial learning and memory function, and that KD treatme...Continue Reading

References

Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·C J HeyserL H Gold
Aug 30, 2001·Nature Immunology·L Steinman
Mar 30, 2004·Annals of Neurology·Patrick G SullivanJong M Rho
Jul 10, 2004·Acta Neurologica Scandinavica·K Wada-IsoeK Nakashima
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giuseppe MatareseChristos S Mantzoros
May 4, 2005·The Journal of Allergy and Clinical Immunology·Giamila Fantuzzi
Aug 20, 2005·Free Radical Biology & Medicine·Malabendu Jana, Kalipada Pahan
Oct 19, 2005·Nutrition & Metabolism·Ingrid Van der AuweraSamuel T Henderson
Apr 13, 2006·Journal of Neurology·Maria Pia AmatoMaria Trojano
May 3, 2006·The American Journal of Pathology·Susanne VoglerSaleh M Ibrahim
Jun 30, 2006·Annals of Neurology·Kristopher J BoughRaymond J Dingledine
Jan 27, 2007·The Cochrane Database of Systematic Reviews·M FarinottiG Filippini
Feb 28, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Do Young Kim, Jong M Rho
Apr 1, 2008·Brain : a Journal of Neurology·N L SicotteS Y Bookheimer
May 6, 2008·Lancet Neurology·Elizabeth G NealJ Helen Cross
May 10, 2008·Journal of Neurochemistry·Stuart G JarrettManisha Patel
May 22, 2008·Brain Pathology·Dimitrios PapadopoulosRichard Reynolds
Jun 26, 2008·Nature Clinical Practice. Neurology·Alla L Zozulya, Heinz Wiendl
Aug 6, 2008·Journal of Leukocyte Biology·Laura PiccioAnne H Cross
Aug 30, 2008·Sub-cellular Biochemistry·Jing X Kang, Karsten H Weylandt
Oct 22, 2008·Free Radical Biology & Medicine·J van HorssenH E de Vries
Nov 13, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Belgin KocerCeyla Irkec
Jan 28, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·L ShintoD Bourdette
Feb 6, 2009·Nature Clinical Practice. Neurology·Lahar R MehtaSteven R Schwid
Feb 24, 2009·Lancet Neurology·Bruce D Trapp, Peter K Stys
May 14, 2009·Multiple Sclerosis : Clinical and Laboratory Research·S D RoosendaalJ J G Geurts
Jul 23, 2009·Brain Research Bulletin·Fabienne GiulianiFrançoise Schenk
Aug 12, 2009·Multiple Sclerosis : Clinical and Laboratory Research·L TiemannP Calabrese
Nov 13, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fang FangShirley ShiDu Yan
Nov 21, 2009·Nutrition & Metabolism·Mary Ann HonorsKimberly P Kinzig
Dec 31, 2009·PloS One·David N RuskinSusan A Masino
Feb 17, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Marina O ZiehnRhonda R Voskuhl
Apr 9, 2010·Journal of Neurochemistry·Do Young KimJong M Rho
Apr 17, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hoda E MohamedSally K Abd El-Latif
May 6, 2010·Expert Review of Clinical Immunology·Vijayshree YadavDennis Bourdette

❮ Previous
Next ❯

Citations

Jul 31, 2013·Neuromolecular Medicine·Francesco MoriDiego Centonze
Apr 15, 2014·Neuroscience and Biobehavioral Reviews·Sagit WeissDiego Centonze
Feb 6, 2013·PloS One·Daniel ParisMichael J Mullan
Mar 12, 2013·Antioxidants & Redox Signaling·Djordje Miljković, Ivan Spasojević
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Robert NisticòDiego Centonze
Jan 17, 2016·Metabolism: Clinical and Experimental·Emily C GraffRobert L Judd
Feb 4, 2016·Multiple Sclerosis International·Mithu Storoni, Gordon T Plant
Jan 8, 2016·Neurology. Neuroimmunology and Neuroinflammation·Eleonora CoccoMaria Giovanna Marrosu
Sep 18, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kohji AbeOsamu Inoue
Mar 19, 2016·Human Brain Mapping·Valentina TomassiniCarlo Pozzilli
Apr 12, 2016·Seizure : the Journal of the British Epilepsy Association·Fen-Fen NiJia-Lun Wen
Dec 17, 2014·Brain Research·Massimiliano Di FilippoPaolo Calabresi
Jul 30, 2015·Neuroscience Letters·Jong M Rho
Oct 9, 2012·Toxicology Mechanisms and Methods·Rogério Corrêa PeresDaniel Araki Ribeiro
Aug 1, 2015·Neural Plasticity·Dominika Justyna Ksiazek-WiniarekAndrzej Glabinski
Dec 24, 2013·Multiple Sclerosis and Related Disorders·Mar Gacias, Patrizia Casaccia
Jun 12, 2013·PloS One·David N RuskinSusan A Masino
Jun 24, 2016·Journal of Neuroinflammation·Nikoo GhaffarianAli Gorji
Nov 9, 2016·Iranian Journal of Psychiatry and Behavioral Sciences·Mohaddese MahboubiOmid Reza Tamtaji
Mar 15, 2015·Trends in Molecular Medicine·Stefan Offermanns, Markus Schwaninger
Nov 23, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Nabeela NathooJeff F Dunn
Jan 13, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jacek ZostawaMonika Adamczyk-Sowa
Feb 1, 2017·Molecular and Cellular Endocrinology·In Young ChoiValter D Longo
May 18, 2013·Journal of Child Neurology·Susan A Masino, David N Ruskin
Jul 5, 2017·Epilepsia·Jacqueline A FrenchMarc A Dichter
Dec 1, 2017·Frontiers in Molecular Neuroscience·Marwa ElaminPaola Sacchetti
Dec 20, 2017·Nutritional Neuroscience·Karisa C SchreckMackenzie C Cervenka
Dec 9, 2017·Epilepsy Currents·Tanya J W McDonald, Mackenzie C Cervenka
May 23, 2019·Neurodegenerative Disease Management·Dejan JakimovskiRobert Zivadinov
May 31, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elaine ShiAndrew F Ducruet
Jun 24, 2017·Molecular Brain·Robert NisticòStephane Peineau
Oct 8, 2019·The International Journal of Neuroscience·Tobore Onojighofia Tobore
Jun 5, 2019·Current Neuropharmacology·Pablo L CardozoFabíola M Ribeiro
May 16, 2019·Neurology. Neuroimmunology and Neuroinflammation·J Nicholas BrentonMyla D Goldman
Dec 14, 2019·Neurology. Neuroimmunology and Neuroinflammation·Josep DalmauScott S Zamvil
Feb 28, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Michael D Kornberg
Feb 15, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ulf H BeierWayne W Hancock
May 15, 2020·Reviews in the Neurosciences·Alessandro RicciElisa Brietzke
May 23, 2018·Disease Models & Mechanisms·Clara Ortega-de San Luis, Tomás J Ryan
Mar 14, 2019·Frontiers in Cellular Neuroscience·Christopher M HenstridgeRosa C Paolicelli
Oct 28, 2019·AJNR. American Journal of Neuroradiology·A BerringtonR E Strowd

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Methods Mentioned

BETA
transgenic
Flow Cytometry
ELISArray

Software Mentioned

MEDx3
EthoVision
Diva
Clampfit
pClamp

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