Inflammation modulates in vitro colonic myoelectric and contractile activity and interstitial cells of Cajal

The American Journal of Physiology
G LuS K Sarna

Abstract

Inflammation suppresses phasic contractile activity in vivo. We investigated whether inflammation also suppresses in vitro phasic contractile activity and, if so, whether this could in part be due to the alteration of specific slow wave characteristics and morphology of the interstitial cells of Cajal (ICC). Circular muscle strips were obtained from normal and inflamed distal canine colon. Inflammation was induced by mucosal exposure to ethanol and acetic acid. The amplitudes of spontaneous, methacholine-induced, substance P-induced, and electrical field stimulation-induced contractions were smaller in inflamed muscle strips than in normal muscle strips. Inflammation reduced the resting membrane potential and the amplitude and duration of slow waves in circular muscle cells. Inflammation did not affect the amplitude of inhibitory junction potentials but did decrease their duration. Ultrastructural studies showed expansion of the extracellular space between circular muscle cells, reduction in the density of ICC and associated neural structures, damage to ICC processes, vacuolization of their cytoplasm, and blebbings of the plasma membrane. We conclude that inflammation-induced alterations of slow wave characteristics contribute ...Continue Reading

References

May 1, 1992·Gastroenterology·Y YamadaM B Grisham
Jun 1, 1991·Digestive Diseases and Sciences·S K Sarna
Apr 1, 1991·Gastroenterology·A K Sethi, S K Sarna
Jul 1, 1991·Digestive Diseases and Sciences·S K Sarna
Oct 1, 1989·The American Journal of Physiology·C Barajas-LópezJ D Huizinga
Apr 1, 1988·The American Journal of Physiology·E P BurkeK M Sanders
Aug 1, 1986·The Journal of Physiology·K M Sanders, T K Smith
Mar 1, 1987·The American Journal of Physiology·T K SmithK M Sanders
Oct 1, 1974·Experimental Parasitology·G A CastroR D Stockstill
Apr 1, 1980·The Journal of Physiology·K G Morgan, J H Szurszewski
Oct 1, 1996·Gastroenterology·J M VanderwindenJ J Vanderhaeghen

❮ Previous
Next ❯

Citations

Nov 30, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J B PucilowskaP K Lund
Nov 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Elizabeth H KampG F Gebhart
Oct 18, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tamás OrdögKenton M Sanders
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·Z L XiaoJ Behar
Feb 15, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·R J WhiteW G Paterson
May 11, 2002·Archives of Histology and Cytology·Ichiro TakayamaShinichi Ohno
Sep 27, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J B PucilowskaP K Lund
Oct 10, 2003·American Journal of Physiology. Cell Physiology·Tamás OrdögKenton M Sanders
Dec 31, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sushil K Sarna
Nov 13, 2004·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Tamás OrdögKenton M Sanders
Oct 17, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M KiyosueH Ozaki
May 18, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·John H WinstonSushil K Sarna
Feb 9, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·X Z Shi, S K Sarna
Mar 21, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·David R LindenGary M Mawe
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·C BossoneT Shea-Donohue
Oct 13, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sushil K Sarna
Mar 20, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A Gonzalez, S K Sarna
Dec 13, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Weibiao CaoVictor E Pricolo
Mar 20, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·B A VallanceS M Collins
Mar 31, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Jianlei ZhaoWenfu Tang
Dec 3, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V E CowlesS K Sarna
Jan 27, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A E LomaxK A Sharkey
Oct 7, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jan D HuizingaJi-Hong Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.