Inflammation of craniofacial muscle induces widespread mechanical allodynia

Neuroscience Letters
Ranjinidevi AmbalavanarDean Dessem

Abstract

The modulation of behavioral responses evoked by local and distant nociceptive stimuli following a discrete somatic injection of complete Freund's adjuvant (CFA) was examined in rats. Inflammation of one craniofacial muscle evoked mechanical allodynia not only in the region of inflammation but also secondary mechanical allodynia in the contralateral head, ipsilateral hindpaw, and contralateral hindpaw. In contrast to this, CFA-induced inflammation of either the hindpaw or gastrocnemius muscle evoked mechanical allodynia restricted to the hindlimb region. The widespread modulation of nocifensive behavior evoked by inflammation of deep craniofacial tissue found in this study resembles the widespread deep tissue pain reported in fibromyalgia, whiplash injury and some temporomandibular disorders and thus may provide insight into the mechanisms of these musculoskeletal pathologies.

References


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Citations

Feb 13, 2009·Cephalalgia : an International Journal of Headache·C S LivermanN E J Berman
Mar 4, 2009·BMC Musculoskeletal Disorders·Birgitta WiesingerAnders Wänman
Sep 18, 2012·Neuroscience Letters·Masafumi YasudaKoichi Iwata
Jul 21, 2009·Muscle & Nerve·Michael J FischerMichael Bernateck
Jul 31, 2009·European Journal of Pain : EJP·Susanna MarklundAnders Wänman
May 12, 2007·Journal of Neurophysiology·Dean DessemRanjinidevi Ambalavanar
Dec 5, 2013·World Journal of Clinical Cases·Michelangelo BuonocoreCesare Bonezzi
Dec 7, 2017·Journal of Molecular Neuroscience : MN·Xiaofeng BaiQing Zhou

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