Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea.

Circulation
Sanja JelicThierry H LeJemtel

Abstract

Indirect evidence implicates endothelial dysfunction in the pathogenesis of vascular diseases associated with obstructive sleep apnea (OSA). We investigated directly whether dysfunction and inflammation occur in vivo in the vascular endothelium of patients with OSA. The effects of continuous positive airway pressure (CPAP) therapy on endothelial function and repair capacity were assessed. Thirty-two patients with newly diagnosed OSA and 15 control subjects were studied. Proteins that regulate basal endothelial nitric oxide (NO) production (endothelial NO synthase [eNOS] and phosphorylated eNOS) and inflammation (cyclooxygenase-2 and inducible NOS) and markers of oxidative stress (nitrotyrosine) were quantified by immunofluorescence in freshly harvested venous endothelial cells before and after 4 weeks of CPAP therapy. Vascular reactivity was measured by flow-mediated dilation. Circulating endothelial progenitor cell levels were quantified to assess endothelial repair capacity. Baseline endothelial expression of eNOS and phosphorylated eNOS was reduced by 59% and 94%, respectively, in patients with OSA compared with control subjects. Expression of both nitrotyrosine and cyclooxygenase-2 was 5-fold greater in patients with OSA th...Continue Reading

References

Apr 1, 1993·The American Review of Respiratory Disease·N B KribbsD F Dinges
Dec 1, 1995·The Journal of Clinical Investigation·J K LiaoP M Hassoun
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·J Vásquez-VivarK A Pritchard
Aug 26, 1998·The Journal of Biological Chemistry·Y XiaJ L Zweier
Jun 17, 1999·Nature Medicine·D W GilroyD A Willoughby
Sep 18, 1999·The European Respiratory Journal·Y PekerM Bende
May 11, 2000·The New England Journal of Medicine·P E PeppardJ Skatrud
Jan 15, 2002·Journal of the American College of Cardiology·Mary C CorrettiUNKNOWN International Brachial Artery Reactivity Task Force
Feb 14, 2002·Journal of Applied Physiology·Paolo C ColomboThierry H Le Jemtel
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Nanduri R Prabhakar
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Larissa DyugovskayaLena Lavie
May 30, 2002·Circulation·Abu S M ShamsuzzamanVirend K Somers
Feb 14, 2003·The New England Journal of Medicine·Jonathan M HillToren Finkel
Oct 11, 2003·American Journal of Respiratory and Critical Care Medicine·Mary S M IpWah-Kit Lam
May 15, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anna SvatikovaVirend K Somers
Aug 24, 2004·Circulation Research·Carmen Urbich, Stefanie Dimmeler
Oct 7, 2004·European Journal of Pharmacology·Hartmut KleinertPetra M Schwarz
Dec 22, 2004·Circulation·Paolo C ColomboThierry H LeJemtel
Apr 6, 2005·Free Radical Biology & Medicine·Toru TanakaEda T Bloom
Aug 3, 2005·Circulation·Elliott M AntmanJoseph Loscalzo
Sep 9, 2005·The New England Journal of Medicine·Nikos WernerGeorg Nickenig
Nov 12, 2005·The New England Journal of Medicine·H Klar YaggiVahid Mohsenin
Jan 28, 2006·American Journal of Respiratory and Critical Care Medicine·Mathias GrebeRichard Schulz
Apr 27, 2007·The New England Journal of Medicine·Robert C Basner
Oct 13, 2007·Basic Research in Cardiology·Nikos WernerGeorg Nickenig

❮ Previous
Next ❯

Citations

Jul 31, 2009·Pediatric Cardiology·Christian M PedersenKeld E Sørensen
Nov 4, 2011·Lung·Saeid GolbidiIsmail Laher
Nov 16, 2011·Pflügers Archiv : European journal of physiology·Richard S T LeungDaniel Stevens
Aug 18, 2010·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Friedrich Felix HoyerDirk Skowasch
Apr 12, 2011·Sleep & Breathing = Schlaf & Atmung·Jing FengBaoyuan Chen
Nov 28, 2012·Sleep & Breathing = Schlaf & Atmung·Macy Mei-Sze LuiMary Sau-Man Ip
Apr 9, 2013·Sleep & Breathing = Schlaf & Atmung·Aylin PihtiliZiya Gulbaran
Apr 2, 2009·Advances in Therapy·Russell Rosenberg, Paul Doghramji
May 8, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masayuki Yoshida
Jan 9, 2009·Journal of Human Hypertension·J-P BaguetJ-L Pépin
Mar 20, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Karuna ChilukuriHugh Calkins
Oct 14, 2011·Current Opinion in Cardiology·Ken Monahan, Susan Redline
May 29, 2009·Clinical and Experimental Pharmacology & Physiology·Rodrigo IturriagaRodrigo Del Rio
Jun 21, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Macy Mei-Sze LuiMary Sau-Man Ip
Aug 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jonathan JunVsevolod Y Polotsky
Oct 31, 2009·Journal of Applied Physiology·Raanan Arens, Hiren Muzumdar
Aug 19, 2011·Respiration; International Review of Thoracic Diseases·John M DoppBarbara J Morgan
Feb 18, 2010·Circulation·Sanja JelicThierry H Le Jemtel
Mar 6, 2010·American Journal of Respiratory and Critical Care Medicine·Leila Kheirandish-GozalDavid Gozal
Jul 14, 2010·American Journal of Respiratory and Critical Care Medicine·Rebecca H MasonMalcolm Kohler
Jul 27, 2010·American Journal of Respiratory and Critical Care Medicine·Brian T PattRami N Khayat
Jul 20, 2010·American Journal of Respiratory and Critical Care Medicine·Barbara J MorganF Javier Nieto
Feb 27, 2009·American Journal of Respiratory Cell and Molecular Biology·Jie ChaoNorberto C Gonzalez
Sep 4, 2010·American Journal of Respiratory Cell and Molecular Biology·Jie ChaoNorberto C Gonzalez
Nov 14, 2013·European Heart Journal. Acute Cardiovascular Care·Hiroshi NakashimaKoji Maemura
Apr 2, 2009·The European Respiratory Journal·D J LedererJ Bhattacharya
Jun 24, 2009·Respiratory Research·Jie ChaoNorberto C Gonzalez
Jul 1, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Masahiko KatoVirend K Somers
Feb 9, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi NakashimaShin Suzuki
Dec 10, 2009·Vascular Health and Risk Management·Sanja JelicThierry H Le Jemtel
Jan 24, 2014·Cardiology Research and Practice·Elizabeth StopfordVikrant Nayar
Jan 9, 2014·Current Diabetes Reports·Bilgay Izci-Balserak, Grace W Pien
Sep 13, 2013·Journal of Cardiovascular Disease Research·Behrouz Jafari, Vahid Mohsenin
Apr 20, 2014·Journal of Cardiovascular Medicine·Margherita PadelettiSanja Jelic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.