Inflammation, oxidative stress and systemic effects in mild chronic obstructive pulmonary disease

International Journal of Immunopathology and Pharmacology
M P Foschino BarbaroPeter J Barnes

Abstract

Chronic obstructive pulmonary diseases (COPD) is a pulmonary disease characterized by systemic abnormalities. The aim of this study is to investigate inflammation and systemic effects in mild COPD. Twenty-seven mild stable smoking related COPD patients and 15 age-matched healthy subjects were enrolled in the study. IL-6, TNF-alpha and IL-4 in plasma, sputum and exhaled breath condensate were measured. We also measured exhaled nitric oxide (NO) and pH in sputum and in breath condensate. Moreover, fat-free mass, body mass index (BMI), respiratory muscle strength, plasma oxidative stress and C-reactive protein (CRP) were measured. Higher concentrations were found of CRP, of diacron reactive oxygen metabolites (DROMs) and of IL-6, TNF-alpha and IL-4 either in plasma or in supernatant of induced sputum or in exhaled breath condensate of COPD subjects compared to healthy controls. Furthermore, higher concentrations were observed of exhaled NO and lower exhaled pH in breath condensate of COPD when compared with healthy subjects. In the group of COPD patients, the subjects with airway reversibility showed an increase of sputum eosinophils and exhaled NO, whereas the subjects without airway obstruction reversibility showed an increase i...Continue Reading

References

Oct 1, 1992·The American Review of Respiratory Disease·T KutsuzawaH Yamabayashi
May 1, 1988·The American Review of Respiratory Disease·J EfthimiouS G Spiro
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·B R Celli
May 1, 1997·American Journal of Respiratory and Critical Care Medicine·P ChanezJ Bousquet
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·A M ScholsE F Wouters
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·T M Hyers
Dec 22, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·L T NguyenP Ritz
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·A SpanevelloG Michetti
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·A PapiL M Fabbri
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·S F van EedenJ C Hogg
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·T SeemungalJ A Wedzicha
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Konstantinos KostikasStelios Loukides
Jul 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Takeshi FujiiStephan F van Eeden
Aug 13, 2002·Chest·Shing-Shing YehUNKNOWN M012 Study Group
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·Michael B ReidHåkan Westerblad
Mar 1, 2003·The European Respiratory Journal·A G N AgustíX Busquets
May 24, 2003·The European Respiratory Journal·G E CarpagnanoP J Barnes
Jun 20, 2003·Respiratory Medicine·B SitkauskieneJ Lötvall
Nov 19, 2003·The European Respiratory Journal. Supplement·E F M Wouters
Nov 19, 2003·The European Respiratory Journal. Supplement·A W BootsA Bast
Jun 29, 2004·The European Respiratory Journal·B R CelliUNKNOWN ATS/ERS Task Force
Oct 10, 2006·International Journal of Immunopathology and Pharmacology·G ServiddioE Altomare

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Citations

Feb 6, 2010·Critical Care Medicine·W Darlene ReidR Luke Harris
May 24, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·K KrügerF C Mooren
Oct 25, 2016·PloS One·Keitaro NakamotoHajime Takizawa
Jun 9, 2020·Oxidative Medicine and Cellular Longevity·Elisabetta ZinelluPietro Pirina
Sep 18, 2020·Biomarkers in Medicine·Somayeh KazeminasabMaryam Khoubnasabjafari
Nov 3, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karsten KrügerFrank C Mooren
Oct 18, 2011·American Journal of Respiratory and Critical Care Medicine·Peter J Barnes, Ian M Adcock
Apr 18, 2013·American Journal of Respiratory Cell and Molecular Biology·Timothy M BahrRussell P Bowler
Jan 17, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph S Hanna
Apr 23, 2009·Neurotoxicity Research·M L CastellaniT C Theoharides
Sep 11, 2012·Multidisciplinary Respiratory Medicine·Barbara Piras, Marc Miravitlles
Dec 17, 2008·Pulmonary Pharmacology & Therapeutics·Rohini SharmaShyam Sunder Sharma

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