PMID: 9418972Jan 7, 1998Paper

Inflammation promotes survival and migration of the CG4 oligodendrocyte progenitors transplanted in the spinal cord of both inflammatory and demyelinated EAE rats

Journal of Neuroscience Research
A TourbahA Baron-Van Evercooren

Abstract

Oligodendrocyte progenitor CG4 cells were labeled with bisbenzimide and transplanted in the lumbar spinal cord of rats 15 to 17 days prior to the induction of experimental autoimmune encephalomyelitis (EAE). EAE was induced by immunization with the encephalitogenic peptide of myelin basic protein (amino acids 68-88; C1) in adjuvant, either alone or in combination with a single injection of an anti-myelin oligodendrocyte glycoprotein (MOG) antibody to enhance central nervous system (CNS) demyelination. In control animals without EAE, the survival and migration capacity of CG4 cells was minimal. In striking contrast, both the survival and migration of this oligodendrocyte progenitor cell line were greatly enhanced in animals with EAE. In both disease models, large number of CG4 cells were still found in the spinal cord 50 days after transplantation, by which time they had migrated up to 6 cm from the transplantation site. Migrating CG4 cells were found in the subpial space, around the ependyma and blood vessels, and as well as in the grey and white matter of the CNS parenchyma. In all these locations, the CG4 cells were often associated with reactive astrocytes. These data strongly support the concept that inflammatory responses ...Continue Reading

References

Jun 1, 1991·Brain : a Journal of Neurology·D BarnesW I McDonald
Sep 1, 1984·Journal of Neuroimmunology·C LinningtonP L Woodhams
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·D L YaoH D Webster
Sep 1, 1995·Developmental Biology·J Fok-SeangJ W Fawcett
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·U TontschI D Duncan
Jan 1, 1994·Annals of Neurology·A Baron-Van Evercooren
Jul 1, 1994·Journal of Neuropathology and Experimental Neurology·W I McDonald
Oct 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L VignaisM Gumpel
Feb 1, 1993·Annals of Neurology·J W PrineasE S Cho
Jul 1, 1995·Brain Pathology·I D Duncan, E A Milward
Sep 1, 1995·Neurobiology of Aging·L M ShafferK R Brunden
Aug 1, 1993·Current Biology : CB·B A BarresM C Raff

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Citations

Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Laura CalzaLuciana Giardino
Sep 9, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·V Tepavcević, W F Blakemore
Sep 10, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tamir Ben-Hur
Apr 23, 2004·Expert Opinion on Investigational Drugs·Martin Stangel
Dec 11, 2003·Molecular and Cellular Neurosciences·Tamir Ben-HurNikolaos Grigoriadis
Jan 25, 2017·BMC Neuroscience·Elise SiegertKarsten H Weylandt
Oct 12, 2001·Glia·T BennN Scolding
Jul 13, 2002·The Journal of Pathology·Nigel L Kennea, Huseyin Mehmet
Apr 25, 2006·Journal of Neurotrauma·John W McDonald, Visar Belegu
Nov 8, 2008·Annals of the New York Academy of Sciences·Tamir Ben-Hur, Steven A Goldman
Jun 10, 2014·Journal of Cellular Physiology·Hany E S MareiCarlo Cenciarelli
Feb 17, 2007·Journal of Neuroscience Research·Arthur E WarringtonMoses Rodriguez
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jaime Imitola
Apr 28, 2010·Experimental Neurology·Angeliki GiannakopoulouGeorgios C Papadopoulos
Jan 18, 2003·Progress in Neurobiology·Martin Stangel, Hans-Peter Hartung
Aug 5, 2006·Neurobiology of Disease·Charles L HoweMoses Rodriguez
Jun 8, 2007·Seminars in Fetal & Neonatal Medicine·Reaz VawdaHuseyin Mehmet
Oct 30, 2007·Journal of the Neurological Sciences·Tamara GlaserOliver Brüstle

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