Inflammation rather than nutritional depletion determines glutamine concentrations and intestinal permeability

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Karel W E HulsewéPeter B Soeters

Abstract

Nutritional depletion has been correlated with low plasma and mucosal glutamine concentrations and with increased intestinal permeability. Since nutritional depletion often is associated with (chronic) inflammatory stress, this study was designed to establish the influence of depletion and inflammation on glutamine concentrations and gut barrier function. Anthropometric parameters were calculated from 26 patients who required artificial nutrition. Glutamine concentrations in plasma and gut mucosa, gut permeability and mucosal morphology were assessed. For determination of the degree of inflammation erythrocyte sedimentation rates and (pre)albumin concentrations were measured. On the basis of these parameters patients were divided into two groups having significant inflammatory stress or not. Similarly, a depleted and a non-depleted group was formed based on percentage ideal body weight, fat-free mass index (FFMI) and percentage weight loss. Glutamine concentrations, gut permeability and villus morphology were compared between the groups. The presence of inflammatory activity had significant negative effects on glutamine concentrations in contrast to the presence or absence of nutritional depletion. Similarly, intestinal permeab...Continue Reading

Citations

Dec 6, 2005·Pediatric Research·Patrizia D'EufemiaSerena Quattrucci
Jun 4, 2014·BMC Veterinary Research·Sandro ImhaslyChristian Gerspach
Dec 1, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Peter SoetersLubos Sobotka
Dec 3, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·L GentonJ Schrenzel
Sep 12, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Peter B SoetersWim G van Gemert
Jan 4, 2012·Annals of Nutrition & Metabolism·P B Soeters, I Grecu
Jul 4, 2008·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Arnold Wald, David Rakel
Aug 19, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Peter B SoetersWim A Buurman
Aug 26, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Anemone van den BergRuurd M van Elburg
Mar 30, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara MetzlerElisabeth Guinet
Mar 31, 2018·Frontiers in Immunology·Cristina DumitruKevin J Maloy
Jan 8, 2020·International Journal of Molecular Sciences·Louise InjarabianBenoit S Marteyn
Jul 29, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wei XuKorinna Huber

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