Inflammation Triggered by Saturated Fat Ingestion Is Linked to Insulin Resistance and Hyperandrogenism in Polycystic Ovary Syndrome.

The Journal of Clinical Endocrinology and Metabolism
Frank GonzálezAnthony J Acton

Abstract

Inflammation and insulin resistance are often present in polycystic ovary syndrome (PCOS). We determined the effect of saturated fat ingestion on mononuclear cell (MNC) nuclear factor-κB (NFκB) activation; NFκB, inhibitory-κBα (IκBα), and tumor necrosis factor-α (TNFα) gene expression; and circulating C-reactive protein (CRP) in women with PCOS. Cross-sectional study. Academic medical center. Twenty reproductive-age women with PCOS (10 lean, 10 with obesity) and 20 ovulatory controls (10 lean, 10 with obesity). Activated NFκB, NFκB heterodimer subunits, IκBα and TNFα messenger ribonucleic acid content and NFκB p65 and IκBα protein content were quantified in mononuclear cells (MNC), and CRP was measured in plasma from blood drawn fasting and 2, 3, and 5 h after saturated fat ingestion. Insulin sensitivity was derived from oral glucose tolerance testing (ISOGTT). Androgen secretion was assessed from blood drawn fasting and 24, 48, and 72 h after human chorionic gonadotropin (HCG) administration. In response to saturated fat ingestion, women with PCOS regardless of weight class exhibited lipid-induced increases in activated NFκB, NFκB, and TNFα gene expression and plasma CRP and decreases in IκBα protein compared with lean control...Continue Reading

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Citations

May 28, 2020·The Journal of Clinical Endocrinology and Metabolism·Bernd Schultes, Milica Popovic
Sep 6, 2020·Current Opinion in Pediatrics·Robert L Rosenfield
Aug 25, 2020·American Journal of Physiology. Endocrinology and Metabolism·Frank GonzálezAnthony J Acton
Jun 7, 2020·Biological Trace Element Research·Demet Aydogan KirmiziAyse Yesim Gocmen
Jan 7, 2021·Journal of Assisted Reproduction and Genetics·Yingliu LuoCuilian Zhang
Apr 4, 2021·International Journal of Molecular Sciences·Shaimaa AboeldalylSaad Amer
May 1, 2021·International Journal of Molecular Sciences·Ewa RudnickaBlazej Meczekalski
Jul 10, 2021·International Journal of Endocrinology·Sahar MazloomiShamim Pilehvari
Oct 12, 2021·American Journal of Physiology. Endocrinology and Metabolism·Frank GonzálezAnthony J Acton

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