Inflammatory activity and vitamin D levels in an MS population treated with rituximab

Multiple Sclerosis Journal - Experimental, Translational and Clinical
Johan LindenPeter Sundström

Abstract

Most multiple sclerosis patients on disease-modifying treatment at Umeå University Hospital are treated with rituximab and the prevalence of vitamin D supplementation has increased over time. Follow-up studies of these off-label treatments are needed. To study inflammatory activity and adverse effects in rituximab-treated multiple sclerosis patients, and associations with 25-hydroxy-vitamin D levels. Retrospectively collected data on repeated estimates of relapses, disability, side effects, magnetic resonance imaging, laboratory measures including 25-hydroxy-vitamin D levels and self-perceived health. In 272 multiple sclerosis patients with a mean follow-up of 43 months, we identified seven possible relapses during active rituximab treatment. On magnetic resonance imaging examination, new T2 lesions were seen in 1.3% (10 out of 792 scans), and 0.25% (two out of 785 scans) showed contrast enhancement. Adjusted 25-hydroxy-vitamin D levels in samples drawn close to all magnetic resonance images with new T2 lesions were lower compared to the remainder (62 vs. 81 nmol/l; P = 0.030). Levels of 25-hydroxy-vitamin D were associated with self-perceived health (r = 0.18, P = 0.041, n = 130) and C-reactive protein (r = -0.13, P = 0.042) b...Continue Reading

References

Jan 1, 1992·International Reviews of Immunology·J ZhangD A Hafler
May 12, 2006·Neurological Research·Gregory P OwensMark P Burgoon
Jan 8, 2008·Journal of Neuroimmunology·Joost SmoldersRaymond Hupperts
Feb 15, 2008·The New England Journal of Medicine·Stephen L HauserUNKNOWN HERMES Trial Group
Dec 11, 2013·Expert Review of Neurotherapeutics·Jonatan SalzerPeter Sundström
Jan 22, 2014·JAMA Neurology·Alberto AscherioChristoph Pohl
Mar 10, 2015·Neurology. Neuroimmunology and Neuroinflammation·Anders SvenningssonTommy Bergenheim
Jun 6, 2015·Acta Neurologica Scandinavica·P Sundström, J Salzer
Jan 1, 2014·Dermato-endocrinology·John J CannellMichael F Holick
May 3, 2016·Statistics in Medicine·Mitchell H GailRaymond J Carroll
Sep 22, 2016·Neurology. Genetics·Brooke RheadLisa F Barcellos
Dec 22, 2016·The New England Journal of Medicine·Stephen L HauserUNKNOWN OPERA I and OPERA II Clinical Investigators
Dec 22, 2016·The New England Journal of Medicine·Xavier MontalbanUNKNOWN ORATORIO Clinical Investigators
Nov 28, 2017·Frontiers in Neurology·Ann Marie WeidemanBibiana Bielekova
May 26, 2018·Acta Neurologica Scandinavica·S G BerntssonA M Landtblom
Jun 8, 2018·Contemporary Clinical Dentistry·S G Damle

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry

Software Mentioned

R
SPSS Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Multiple Sclerosis : Clinical and Laboratory Research
L SandbergPeter Sundström
European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Ellen M MowryE Waubant
© 2022 Meta ULC. All rights reserved